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Journal of Neuroscience, Vol 14, 7130-7140, Copyright © 1994 by Society for Neuroscience
Receptive field analysis and orientation selectivity of postsynaptic potentials of simple cells in cat visual cortex
X Pei, TR Vidyasagar, M Volgushev and OD Creutzfeldt
Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany.
Postsynaptic potentials (PSPs) were recorded from cat striate cortical
cells by the whole-cell in vivo recording technique using patch-clamp
electrodes. EPSPs and IPSPs evoked by flashing bars on the receptive field
at different positions and orientations revealed the spatial structure of
the excitatory and inhibitory inputs. The elongation of the excitatory
input field (length:width ratio) was found to be minimal (mean ratio of
1.7) and much lower than those reported for spike discharges.
Two-dimensional receptive field response profiles of early PSPs were
recorded by flashing a small spot of light over a square matrix covering
the receptive field. These recordings also showed only mild degrees of
elongations of the receptive field. Such elongations could be the result of
either an excitatory input from the geniculate that is already biased for
orientation or an excitatory convergence from a limited number of LGN
fields arranged in a row. In most first- order cells, we found that
inhibition was contributing significantly to orientation selectivity. Often
prominent IPSPs could be evoked by stimuli of nonoptimum orientations.
Presence of inhibition could also be inferred by the way that EPSPs were
sharply cut off by inhibition. When the amplitude of an EPSP was measured
at different latencies after its onset, the EPSP was found to be very
broadly tuned to orientation at the beginning, but showing increasing
orientation selectivity with time. It is proposed that this progressive
development of orientation selectivity is due to (1) inhibitory inputs
arriving after the first wave of excitation, (2) intracortical excitatory
inputs from other cells tuned to similar orientations, and (3)
voltage-sensitive mechanisms such as NMDA channels.
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