 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 14, 7180-7191, Copyright © 1994 by Society for Neuroscience
The L2/HNK-1 carbohydrate is preferentially expressed by previously motor axon-associated Schwann cells in reinnervated peripheral nerves
R Martini, M Schachner and TM Brushart
Department of Neurobiology, Swiss Federal Institute of Technology, Honggerberg, Zurich.
The carbohydrate epitope L2/HNK-1 (hereafter designated L2) is expressed in
the adult mouse by myelinating Schwann cells of ventral roots and muscle
nerves, but rarely by those of dorsal roots or cutaneous nerves. Since
substrate-coated L2 glycolipids promote outgrowth of cultured motor but not
sensory neurons, L2 may thus influence the preferential reinnervation of
muscle nerves by regenerating motor axons in vivo. In the present study, we
have analyzed the influence of regenerating axons on L2 expression by
reinnervated Schwann cells by directing motor or sensory axons into the
muscle and cutaneous branches of femoral nerves of 8-week-old mice. We
observed that regenerating axons from cutaneous branches did not lead to
immunocytochemically detectable L2 expression in muscle or cutaneous nerve
branches. Axons regenerating from muscle branches led to a weak L2
expression by few Schwann cells of the cutaneous branch, but provoked a
strong L2 expression by many Schwann cells of the muscle branch.
Myelinating Schwann cells previously associated with motor axons thus
differed from previously sensory axon-associated myelinating Schwann cells
in their ability to express L2 when contacted by motor axons. This
upregulation of L2 expression during critical stages of reinnervation may
provide motor axons regenerating into the appropriate, muscle pathways with
an advantage over those regenerating into the inappropriate, sensory
pathways.
This article has been cited by other articles:
|
|
|
|
 
C. K. Franz, U. Rutishauser, and V. F. Rafuse
Intrinsic neuronal properties control selective targeting of regenerating motoneurons
Brain,
June 1, 2008;
131(6):
1492 - 1505.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Hoke, R. Redett, H. Hameed, R. Jari, C. Zhou, Z. B. Li, J. W. Griffin, and T. M. Brushart
Schwann cells express motor and sensory phenotypes that regulate axon regeneration.
J. Neurosci.,
September 20, 2006;
26(38):
9646 - 9655.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Redett, R. Jari, T. Crawford, Y.-G. Chen, C. Rohde, and T. M. Brushart
Peripheral Pathways Regulate Motoneuron Collateral Dynamics
J. Neurosci.,
October 12, 2005;
25(41):
9406 - 9412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Hall
The response to injury in the peripheral nervous system
J Bone Joint Surg Br,
October 1, 2005;
87-B(10):
1309 - 1319.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Ong, M. Suzuki, F. Belot, J.-C. Yeh, I. Franceschini, K. Angata, O. Hindsgaul, and M. Fukuda
Biosynthesis of HNK-1 Glycans on O-Linked Oligosaccharides Attached to the Neural Cell Adhesion Molecule (NCAM). THE REQUIREMENT FOR CORE 2 beta 1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE AND THE MUSCLE-SPECIFIC DOMAIN IN NCAM
J. Biol. Chem.,
May 10, 2002;
277(20):
18182 - 18190.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Forghani, L. Garofalo, D. R. Foran, H. F. Farhadi, P. Lepage, T. J. Hudson, I. Tretjakoff, P. Valera, and A. Peterson
A Distal Upstream Enhancer from the Myelin Basic Protein Gene Regulates Expression in Myelin-Forming Schwann Cells
J. Neurosci.,
June 1, 2001;
21(11):
3780 - 3787.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. A. Al-Majed, C. M. Neumann, T. M. Brushart, and T. Gordon
Brief Electrical Stimulation Promotes the Speed and Accuracy of Motor Axonal Regeneration
J. Neurosci.,
April 1, 2000;
20(7):
2602 - 2608.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. M. Brushart, J. Gerber, P. Kessens, Y.-G. Chen, and R. M. Royall
Contributions of Pathway and Neuron to Preferential Motor Reinnervation
J. Neurosci.,
November 1, 1998;
18(21):
8674 - 8681.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Burstyn-Cohen, A. Frumkin, Y.-T. Xu, S. S. Scherer, and A. Klar
Accumulation of F-Spondin in Injured Peripheral Nerve Promotes the Outgrowth of Sensory Axons
J. Neurosci.,
November 1, 1998;
18(21):
8875 - 8885.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P Lamoureux, R. Buxbaum, and S. Heidemann
Axonal outgrowth of cultured neurons is not limited by growth cone competition
J. Cell Sci.,
January 11, 1998;
111(21):
3245 - 3252.
[Abstract]
[PDF]
|
|
|
|
|
|
|
H. Bakker, I. Friedmann, S. Oka, T. Kawasaki, N. Nifant'ev, M. Schachner, and N. Mantei
Expression Cloning of a cDNA Encoding a Sulfotransferase Involved in the Biosynthesis of the HNK-1 Carbohydrate Epitope
J. Biol. Chem.,
November 21, 1997;
272(47):
29942 - 29946.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Xia, M. R. Evers, H.-G. Kang, M. Schachner, and J. U. Baenziger
Molecular Cloning and Expression of the Pituitary Glycoprotein Hormone N-Acetylgalactosamine-4-O-sulfotransferase
J. Biol. Chem.,
December 1, 2000;
275(49):
38402 - 38409.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
