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Journal of Neuroscience, Vol 14, 7331-7346, Copyright © 1994 by Society for Neuroscience
T-cadherin expression delineates specific regions of the developing motor axon-hindlimb projection pathway
BJ Fredette and B Ranscht
La Jolla Cancer Research Foundation, California 92037.
T-cadherin is a unique member of the cadherin family anchored to the
membrane by a glycosyl phosphatidylinositol moiety (Ranscht and Dours-
Zimmermann, 1991). T-cadherin's distribution in the developing motor axon
pathway was mapped by immunocytochemistry in the chick lumbosacral region
as spinal neurons project to and innervate hindlimb muscle. On growing
motor axons, T-cadherin was expressed biphasically. Initially, uniform
T-cadherin expression occurred on motor neurons as they projected between
the spinal cord and the base of the hindlimb (stage 21-24), and then
decreased as the axons sorted to form dorsal, ventral and muscle nerve
trunks (stage 25-27). Later, as motor axons entered and formed terminal
axon arbors and synapses in muscle (stages 28-36), expression reoccurred
heterogeneously among motor neuron pools. Thus, T- cadherin may guide the
growth and fasciculation of all motor neurons during early axon extension,
but only affect particular populations during the later expression period.
In the mesenchyme of the motor axon pathway, T-cadherin was restricted to
regions avoided by growing axons: the posterior-half sclerotome before and
during the projection of motor axons through the T-cadherin-negative
anterior half, and the extrasynaptic surfaces of developing muscle. The
temporal and spatial expression patterns of T-cadherin and neurite
outgrowth-promoting N- cadherin were complementary both in nerve and muscle
tissues. Thus, in the posterior sclerotome and in maturing muscle,
T-cadherin may act as a negative regulator that works in concert with
neurite growth- promoting molecules to guide motor axons to their
peripheral targets.
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