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Journal of Neuroscience, Vol 14, 7594-7607, Copyright © 1994 by Society for Neuroscience
Effect of serotonin depletion on vibrissa-related patterns of thalamic afferents in the rat's somatosensory cortex
CA Bennett-Clarke, MJ Leslie, RD Lane and RW Rhoades
Department of Anatomy, Medical College of Ohio, Toledo 43699.
To investigate the role of 5-HT in the development of the somatosensory
cortex, this amine was depleted in newborn (P-0) rats with a single
subcutaneous injection of the toxin 5,7-dihydroxytryptamine (5,7-DHT) and
thalamocortical organization was assayed by application of the carbocyanine
dye Di-I to the thalamocortical radiations or ventrobasal thalamus, or by
staining cortical sections for AChE or cytochrome oxidase (CO).
High-performance liquid chromatographic analysis of cortices from animals
killed on P-6 or P > 60 demonstrated that 5,7-DHT treatment resulted in
85.04 +/- 12.6% and 72.5 +/- 1.5% reductions in cortical 5-HT,
respectively. Alternate cortices from the brains of animals killed on P-6
processed for 5-HT immunoreactivity demonstrated a complete absence of the
vibrissa-related pattern of immunoreactivity and only a small number of
coarse immunoreactive axons. The 85% depletion of 5-HT did not alter the
somatotopic organization of thalamocortical afferents in animals killed on
P-6 or P > 60, but it did cause 30.5 +/- 7.3% and 19.1 +/- 3.7%
reductions in the cross- sectional areas of the patches of thalamocortical
afferents corresponding to the long mystacial vibrissae (p < 0.05).
These reductions were not associated with significant reductions in either
brain or cortical weight or with decreases in the dimensions of the
thalamic representation of the vibrissa follicles. These results indicate
that 5-HT plays a significant role in the development of the thalamic
innervation of the primary somatosensory cortex.
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