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Journal of Neuroscience, Vol 14, 7665-7679, Copyright © 1994 by Society for Neuroscience
The cortical component of experience-dependent synaptic plasticity in the rat barrel cortex
K Fox
Department of Physiology, University of Minnesota, Minneapolis 55455.
Rats were raised with altered tactile experience from P0 by removing all
but one vibrissa (D1) from one side of the face (D1-spared animals). This
procedure (univibrissa rearing) has previously been shown to cause neurons
in cortical barrels surrounding D1 to develop greater than normal responses
to D1 vibrissa stimulation and smaller than normal responses to principal
vibrissa stimulation (Fox, 1992). In this study, it was found that the
potentiated D1 responses could be attenuated by acute microlesions placed
in the D1 barrel, while principal vibrissa responses were unchanged or even
slightly elevated for the same cases. The ratio of the average D1 to
principal vibrissa response was approximately proportional to the volume of
tissue damaged in the D1 barrel. This result implies that the synaptic
plasticity seen in cortex of D1-spared animals is due to synaptic changes
that take place within the barrel cortex rather than to relay of changes
occurring at a subcortical level. In addition, lesions aimed at the septum
between D1 and an adjacent barrel almost completely abolished responses to
D1 stimulation in that barrel, including short-latency responses (5-10
msec). Only neurons severed horizontally from D1 were affected. Neurons
that maintained a connection with the D1 barrel via a bridge of septal
tissue preserved their usual elevated levels of response to D1 stimulation
and their aberrant short-latency responses. This result implies that
pathways radiating out from the D1 barrel/column, and connecting neurons in
the D1 barrel to cells in surrounding barrels, undergo synaptic plasticity
induced by univibrissa rearing.
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