 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 14, 599-610, Copyright © 1994 by Society for Neuroscience
Input-output organization of the sensorimotor striatum in the squirrel monkey
AW Flaherty and AM Graybiel
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
The basal ganglia receive massive inputs from the neocortex and send
outputs that exert both inhibitory and disinhibitory control over parts of
the frontal cortex and brainstem. Between these basal ganglia inputs and
outputs lies the striatum, which receives most of the cortical afferents
and projects to the basal ganglia output nuclei--the globus pallidus and
substantia nigra. To analyze this system we conjointly labeled, in squirrel
monkeys, sensorimotor cortical inputs to the striatum and striatal outputs
to the globus pallidus. Anterograde tracers were injected into the motor
(MI) and somatosensory (SI) cortical body maps, at sites determined by
electrophysiological stimulation and recording. Retrograde tracers were
stereotaxically injected into the external and internal pallidal segments
(GPe and GPi). We found that multiple dispersed modules ("matrisomes") in
the putamen that all received inputs from single body-part representations
in sensorimotor cortex could, in turn, send convergent outputs to single
sites in the pallidum. This divergence-reconvergence pattern was found for
both GPe and GPi sites, and for inputs from both SI and MI cortex. Thus,
information from a single functional region in the cortex can be split up
at the striatal stage only to be brought back together in the pallidum. The
temporary divergence may increase lateral interactions between sensorimotor
matrisomes, as well as between matrisomes and striosomes. One function of
striatal modularity may thus be to set up an associative network in the
striatum, which might contribute to sensorimotor learning. We also found
that some sets of matrisomes did not receive strong sensorimotor inputs,
even though they projected to regions of GPe and GPi that are near the
sensorimotor- recipient zones described above. Thus, the matrisomal system
may sort MI/SI inputs and other inputs before transfer to paired regions of
GPe and GPi.
This article has been cited by other articles:
|
|
|
|
 
B. R. Miller, A. G. Walker, A. S. Shah, S. J. Barton, and G. V. Rebec
Dysregulated Information Processing by Medium Spiny Neurons in Striatum of Freely Behaving Mouse Models of Huntington's Disease
J Neurophysiol,
October 1, 2008;
100(4):
2205 - 2216.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. O. Tan and D. Bullock
A Local Circuit Model of Learned Striatal and Dopamine Cell Responses under Probabilistic Schedules of Reward
J. Neurosci.,
October 1, 2008;
28(40):
10062 - 10074.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Draganski, F. Kherif, S. Kloppel, P. A. Cook, D. C. Alexander, G. J. M. Parker, R. Deichmann, J. Ashburner, and R. S. J. Frackowiak
Evidence for Segregated and Integrative Connectivity Patterns in the Human Basal Ganglia
J. Neurosci.,
July 9, 2008;
28(28):
7143 - 7152.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Mounayar, S. Boulet, D. Tande, C. Jan, M. Pessiglione, E. C. Hirsch, J. Feger, M. Savasta, C. Francois, and L. Tremblay
A new model to study compensatory mechanisms in MPTP-treated monkeys exhibiting recovery
Brain,
November 1, 2007;
130(11):
2898 - 2914.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Tippett, H. J. Waldvogel, S. J. Thomas, V. M. Hogg, W. v. Roon-Mom, B. J. Synek, A. M. Graybiel, and R. L. M. Faull
Striosomes and mood dysfunction in Huntington's disease
Brain,
January 1, 2007;
130(1):
206 - 221.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Becerra, S. Morris, S. Bazes, R. Gostic, S. Sherman, J. Gostic, G. Pendse, E. Moulton, S. Scrivani, D. Keith, et al.
Trigeminal Neuropathic Pain Alters Responses in CNS Circuits to Mechanical (Brush) and Thermal (Cold and Heat) Stimuli.
J. Neurosci.,
October 18, 2006;
26(42):
10646 - 10657.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Feekes and M. D. Cassell
The vascular supply of the functional compartments of the human striatum
Brain,
August 1, 2006;
129(8):
2189 - 2201.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. R. Marchand and V. Dilda
New Models of Frontal-Subcortical Skeletomotor Circuit Pathology in Tardive Dyskinesia
Neuroscientist,
June 1, 2006;
12(3):
186 - 198.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. Francois, D. Grabli, K. McCairn, C. Jan, C. Karachi, E.-C. Hirsch, J. Feger, and L. Tremblay
Behavioural disorders induced by external globus pallidus dysfunction in primates II. Anatomical study
Brain,
September 1, 2004;
127(9):
2055 - 2070.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. E. Hoover, Z. S. Hoffer, and K. D. Alloway
Projections From Primary Somatosensory Cortex to the Neostriatum: The Role of Somatotopic Continuity in Corticostriatal Convergence
J Neurophysiol,
March 1, 2003;
89(3):
1576 - 1587.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kaneda, A. Nambu, H. Tokuno, and M. Takada
Differential Processing Patterns of Motor Information Via Striatopallidal and Striatonigral Projections
J Neurophysiol,
September 1, 2002;
88(3):
1420 - 1432.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. M. Bronte-Stewart, A. Y. Minn, K. Rodrigues, E. L. Buckley, and L. M. Nashner
Postural instability in idiopathic Parkinson's disease: the role of medication and unilateral pallidotomy
Brain,
September 1, 2002;
125(9):
2100 - 2114.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Saka, M. Iadarola, D. J. Fitzgerald, and A. M. Graybiel
Local circuit neurons in the striatum regulate neural and behavioral responses to dopaminergic stimulation
PNAS,
June 25, 2002;
99(13):
9004 - 9009.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Zheng and C. J. Wilson
Corticostriatal Combinatorics: The Implications of Corticostriatal Axonal Arborizations
J Neurophysiol,
February 1, 2002;
87(2):
1007 - 1017.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. L. Brown, S. M. Feldman, D. M. Smith, J. R. Cavanaugh, R. F. Ackermann, and A. M. Graybiel
Differential Metabolic Activity in the Striosome and Matrix Compartments of the Rat Striatum during Natural Behaviors
J. Neurosci.,
January 1, 2002;
22(1):
305 - 314.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Hikosaka, Y. Takikawa, and R. Kawagoe
Role of the Basal Ganglia in the Control of Purposive Saccadic Eye Movements
Physiol Rev,
July 1, 2000;
80(3):
953 - 978.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. N. Haber, J. L. Fudge, and N. R. McFarland
Striatonigrostriatal Pathways in Primates Form an Ascending Spiral from the Shell to the Dorsolateral Striatum
J. Neurosci.,
March 15, 2000;
20(6):
2369 - 2382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. D. Alloway, J. Crist, J. J. Mutic, and S. A. Roy
Corticostriatal Projections from Rat Barrel Cortex Have an Anisotropic Organization that Correlates with Vibrissal Whisking Behavior
J. Neurosci.,
December 15, 1999;
19(24):
10908 - 10922.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. E. Hoover and P. L. Strick
The Organization of Cerebellar and Basal Ganglia Outputs to Primary Motor Cortex as Revealed by Retrograde Transneuronal Transport of Herpes Simplex Virus Type 1
J. Neurosci.,
February 15, 1999;
19(4):
1446 - 1463.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. Bevan, P. A. C. Booth, S. A. Eaton, and J. P. Bolam
Selective Innervation of Neostriatal Interneurons by a Subclass of Neuron in the Globus Pallidus of the Rat
J. Neurosci.,
November 15, 1998;
18(22):
9438 - 9452.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. O. West
Anesthetics Eliminate Somatosensory-Evoked Discharges of Neurons in the Somatotopically Organized Sensorimotor Striatum of the Rat
J. Neurosci.,
November 1, 1998;
18(21):
9055 - 9068.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Kincaid, T. Zheng, and C. J. Wilson
Connectivity and Convergence of Single Corticostriatal Axons
J. Neurosci.,
June 15, 1998;
18(12):
4722 - 4731.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Boecker, A. Dagher, A. O. Ceballos-Baumann, R. E. Passingham, M. Samuel, K. J. Friston, J.-B. Poline, C. Dettmers, B. Conrad, and D. J. Brooks
Role of the Human Rostral Supplementary Motor Area and the Basal Ganglia in Motor Sequence Control: Investigations With H2 15O PET
J Neurophysiol,
February 1, 1998;
79(2):
1070 - 1080.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Cheng, K. S. Saleem, and K. Tanaka
Organization of Corticostriatal and Corticoamygdalar Projections Arising from the Anterior Inferotemporal Area TE of the Macaque Monkey: A Phaseolus vulgaris Leucoagglutinin Study
J. Neurosci.,
October 15, 1997;
17(20):
7902 - 7925.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. M. Carelli, M. Wolske, and M. O. West
Loss of Lever Press-Related Firing of Rat Striatal Forelimb Neurons after Repeated Sessions in a Lever Pressing Task
J. Neurosci.,
March 1, 1997;
17(5):
1804 - 1814.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. Bevan, N. P. Clarke, and J. P. Bolam
Synaptic Integration of Functionally Diverse Pallidal Information in the Entopeduncular Nucleus and Subthalamic Nucleus in the Rat
J. Neurosci.,
January 1, 1997;
17(1):
308 - 324.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Graybiel, T Aosaki, A. Flaherty, and M Kimura
The basal ganglia and adaptive motor control
Science,
September 23, 1994;
265(5180):
1826 - 1831.
[Abstract]
[PDF]
|
|
|
|
