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Journal of Neuroscience, Vol 14, 712-720, Copyright © 1994 by Society for Neuroscience
NK-1 and NK-3 type tachykinin receptor mRNA expression in the rat spinal cord dorsal horn is increased during adjuvant or formalin- induced nociception
KE McCarson and JE Krause
Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, Missouri 63110.
Substance P (SP) and other related tachykinins such as neurokinin B (NKB)
have been studied widely as mediators of sensory information. The release
of SP into the dorsal horn of the spinal cord is increased during
nociception, and SP activates nociception-specific dorsal horn neurons. The
tachykinin NKB has antinociceptive effects in the spinal cord and is
contained in intrinsic spinal neurons; thus, NKB may also contribute to the
processing of sensory information. Both neurokinin-1 (NK-1) and
neurokinin-3 (NK-3) receptors have been localized in the superficial
laminae of the dorsal horn. This study investigated changes in NK-1 and
NK-3 receptor mRNA expression during nociception. Following injection of
either formalin or complete Freund's adjuvant (CFA) into one hindpaw, the
levels of expression of NK-1 and NK-3 mRNAs in the spinal cord dorsal horn
and preprotachykinin (PPT) mRNA expression in the lumbar dorsal root
ganglia (DRG) were quantitated using solution hybridization-nuclease
protection assays. Peptide and receptor mRNA expression levels were
normalized to beta-actin mRNA levels, which did not change during the
treatments. Formalin (2 or 6 hr) or CFA (4 d) injection produced
approximately a twofold increase in SP-encoding PPT mRNA expression in the
ipsilateral lumbar DRG. Increased activity in primary afferent neurons
containing SP may stimulate the production of SP precursors, providing
substrate for increased SP production, release, and turnover in the dorsal
horn and periphery.(ABSTRACT TRUNCATED AT 250 WORDS)
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