GFAP promoter directs astrocyte-specific expression in transgenic mice

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):
Year:		Vol:		Page:

HOME | SEARCH | ARCHIVE | SUBSCRIBE | CONTACT | HELP

This Article

Full Text (PDF)

Submit an eLetter

Alert me when this article is cited

Alert me when eLetters are posted

Alert me if a correction is posted

Citation Map

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Brenner, M.

Articles by Messing, A.

Search for Related Content

PubMed

PubMed Citation

Articles by Brenner, M.

Articles by Messing, A.

Previous Article | Next Article

Journal of Neuroscience, Vol 14, 1030-1037, Copyright © 1994 by Society for Neuroscience

ARTICLE

GFAP promoter directs astrocyte-specific expression in transgenic mice

M Brenner, WC Kisseberth, Y Su, F Besnard and A Messing
Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
Glial fibrillary acidic protein (GFAP) is an intermediate-filament protein expressed abundantly and almost exclusively in astrocytes of the CNS. We are studying transcriptional regulation of the GFAP gene to gain insight into astrocyte function and also to develop an astrocyte- specific expression system for manipulating brain physiology. In this work, we have produced transgenic mice carrying the bacterial lacZ reporter gene linked to a 2.2 kilobase 5'-flanking sequence derived from the human GFAP gene that previously was shown to direct astrocyte- specific transcription in cultured cells. We report that this promoter directs expression to astrocytes in the CNS. In addition, the upregulation of GFAP gene activity that follows injury to the brain was mimicked by the transgene. One of the transgenes was found to be X- linked and appeared to undergo the usual random inactivation that achieves gene dosage compensation in females. The brains of hemizygous females stained uniformly rather than displaying mosaic patches, indicating that astrocytes intermingle following their formation. The specific expression of the GFAP-lacZ transgene means that it is now possible to target expression of other heterologous genes to astrocytes in vivo, and to study the mechanisms for reactive gliosis at the DNA level.

This article has been cited by other articles:

B. Yang, Z. Zador, and A. S. Verkman
Glial Cell Aquaporin-4 Overexpression in Transgenic Mice Accelerates Cytotoxic Brain Swelling
J. Biol. Chem., May 30, 2008; 283(22): 15280 - 15286.
[Abstract] [Full Text] [PDF]

A. C. Arnold, A. Sakima, D. Ganten, C. M. Ferrario, and D. I. Diz
Modulation of Reflex Function by Endogenous Angiotensins in Older Transgenic Rats With Low Glial Angiotensinogen
Hypertension, May 1, 2008; 51(5): 1326 - 1331.
[Abstract] [Full Text] [PDF]

B. Djukic, K. B. Casper, B. D. Philpot, L.-S. Chin, and K. D. McCarthy
Conditional Knock-Out of Kir4.1 Leads to Glial Membrane Depolarization, Inhibition of Potassium and Glutamate Uptake, and Enhanced Short-Term Synaptic Potentiation
J. Neurosci., October 17, 2007; 27(42): 11354 - 11365.
[Abstract] [Full Text] [PDF]

M. R. Regan, Y. H. Huang, Y. S. Kim, M. I. Dykes-Hoberg, L. Jin, A. M. Watkins, D. E. Bergles, and J. D. Rothstein
Variations in Promoter Activity Reveal a Differential Expression and Physiology of Glutamate Transporters by Glia in the Developing and Mature CNS
J. Neurosci., June 20, 2007; 27(25): 6607 - 6619.
[Abstract] [Full Text] [PDF]

C. J. Lee, G. Mannaioni, H. Yuan, D. H. Woo, M. B. Gingrich, and S. F. Traynelis
Astrocytic control of synaptic NMDA receptors
J. Physiol., June 15, 2007; 581(3): 1057 - 1081.
[Abstract] [Full Text] [PDF]

M. Hoser, S. L. Baader, M. R. Bosl, A. Ihmer, M. Wegner, and E. Sock
Prolonged Glial Expression of Sox4 in the CNS Leads to Architectural Cerebellar Defects and Ataxia
J. Neurosci., May 16, 2007; 27(20): 5495 - 5505.
[Abstract] [Full Text] [PDF]

J.-Q. Liu, J. W. Carl Jr, P. S. Joshi, A. RayChaudhury, X.-A. Pu, F.-D. Shi, and X.-F. Bai
CD24 on the Resident Cells of the Central Nervous System Enhances Experimental Autoimmune Encephalomyelitis
J. Immunol., May 15, 2007; 178(10): 6227 - 6235.
[Abstract] [Full Text] [PDF]

K. P. Greenberg, S. F. Geller, D. V. Schaffer, and J. G. Flannery
Targeted Transgene Expression in Muller Glia of Normal and Diseased Retinas Using Lentiviral Vectors
Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1844 - 1852.
[Abstract] [Full Text] [PDF]

Y. M. Ganat, J. Silbereis, C. Cave, H. Ngu, G. M. Anderson, Y. Ohkubo, L. R. Ment, and F. M. Vaccarino
Early Postnatal Astroglial Cells Produce Multilineage Precursors and Neural Stem Cells In Vivo.
J. Neurosci., August 15, 2006; 26(33): 8609 - 8621.
[Abstract] [Full Text] [PDF]

S. M. Gopalan, K. M. Wilczynska, B. S. Konik, L. Bryan, and T. Kordula
Nuclear Factor-1-X Regulates Astrocyte-specific Expression of the {alpha}1-Antichymotrypsin and Glial Fibrillary Acidic Protein Genes
J. Biol. Chem., May 12, 2006; 281(19): 13126 - 13133.
[Abstract] [Full Text] [PDF]

S. M. Gopalan, K. M. Wilczynska, B. S. Konik, L. Bryan, and T. Kordula
Astrocyte-specific Expression of the {alpha}1-Antichymotrypsin and Glial Fibrillary Acidic Protein Genes Requires Activator Protein-1
J. Biol. Chem., January 27, 2006; 281(4): 1956 - 1963.
[Abstract] [Full Text] [PDF]

R. Brambilla, V. Bracchi-Ricard, W.-H. Hu, B. Frydel, A. Bramwell, S. Karmally, E. J. Green, and J. R. Bethea
Inhibition of astroglial nuclear factor {kappa}B reduces inflammation and improves functional recovery after spinal cord injury
J. Exp. Med., July 5, 2005; 202(1): 145 - 156.
[Abstract] [Full Text] [PDF]

W. Lin, H. P. Harding, D. Ron, and B. Popko
Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-{gamma}
J. Cell Biol., May 23, 2005; 169(4): 603 - 612.
[Abstract] [Full Text] [PDF]

D. Huang, J. Wujek, G. Kidd, T. T. He, A. Cardona, M. E. Sasse, E. J. Stein, J. Kish, M. Tani, I. F. Charo, et al.
Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice
FASEB J, May 1, 2005; 19(7): 761 - 772.
[Abstract] [Full Text] [PDF]

H. West, W. D. Richardson, and M. Fruttiger
Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes
Development, April 15, 2005; 132(8): 1855 - 1862.
[Abstract] [Full Text] [PDF]

M. S. Forman, D. Lal, B. Zhang, D. V. Dabir, E. Swanson, V. M.-Y. Lee, and J. Q. Trojanowski
Transgenic Mouse Model of Tau Pathology in Astrocytes Leading to Nervous System Degeneration
J. Neurosci., April 6, 2005; 25(14): 3539 - 3550.
[Abstract] [Full Text] [PDF]

M. Xin, T. Yue, Z. Ma, F.-f. Wu, A. Gow, and Q. R. Lu
Myelinogenesis and Axonal Recognition by Oligodendrocytes in Brain Are Uncoupled in Olig1-Null Mice
J. Neurosci., February 9, 2005; 25(6): 1354 - 1365.
[Abstract] [Full Text] [PDF]

W. Lin, A. Kemper, K. D. McCarthy, P. Pytel, J.-P. Wang, I. L. Campbell, M. F. Utset, and B. Popko
Interferon-{gamma} Induced Medulloblastoma in the Developing Cerebellum
J. Neurosci., November 10, 2004; 24(45): 10074 - 10083.
[Abstract] [Full Text] [PDF]

K. Stankovic, C. Rio, A. Xia, M. Sugawara, J. C. Adams, M. C. Liberman, and G. Corfas
Survival of Adult Spiral Ganglion Neurons Requires erbB Receptor Signaling in the Inner Ear
J. Neurosci., October 6, 2004; 24(40): 8651 - 8661.
[Abstract] [Full Text] [PDF]

X.-F. Bai, O. Li, Q. Zhou, H. Zhang, P. S. Joshi, X. Zheng, Y. Liu, Y. Wang, P. Zheng, and Y. Liu
CD24 Controls Expansion and Persistence of Autoreactive T Cells in the Central Nervous System during Experimental Autoimmune Encephalomyelitis
J. Exp. Med., August 16, 2004; 200(4): 447 - 458.
[Abstract] [Full Text] [PDF]

N. Lochard, G. Thibault, D. W. Silversides, R. M. Touyz, and T. L. Reudelhuber
Chronic Production of Angiotensin IV in the Brain Leads to Hypertension That Is Reversible With an Angiotensin II AT1 Receptor Antagonist
Circ. Res., June 11, 2004; 94(11): 1451 - 1457.
[Abstract] [Full Text] [PDF]

K. Sriram, S. A. Benkovic, M. A. Hebert, D. B. Miller, and J. P. O'Callaghan
Induction of gp130-related Cytokines and Activation of JAK2/STAT3 Pathway in Astrocytes Precedes Up-regulation of Glial Fibrillary Acidic Protein in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Neurodegeneration: KEY SIGNALING PATHWAY FOR ASTROGLIOSIS IN VIVO?
J. Biol. Chem., May 7, 2004; 279(19): 19936 - 19947.
[Abstract] [Full Text] [PDF]

G. Bienvenu, D. Seurin, P. Grellier, P. Froment, M. Baudrimont, P. Monget, Y. Le Bouc, and S. Babajko
Insulin-Like Growth Factor Binding Protein-6 Transgenic Mice: Postnatal Growth, Brain Development, and Reproduction Abnormalities
Endocrinology, May 1, 2004; 145(5): 2412 - 2420.
[Abstract] [Full Text] [PDF]

M. Rauer, J. Gotz, D. Schuppli, P. Staeheli, and J. Hausmann
Transgenic Mice Expressing the Nucleoprotein of Borna Disease Virus in either Neurons or Astrocytes: Decreased Susceptibility to Homotypic Infection and Disease
J. Virol., April 1, 2004; 78(7): 3621 - 3632.
[Abstract] [Full Text] [PDF]

H. Guo, L. Lai, M. E.R. Butchbach, M. P. Stockinger, X. Shan, G. A. Bishop, and C.-l. G. Lin
Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice
Hum. Mol. Genet., October 1, 2003; 12(19): 2519 - 2532.
[Abstract] [Full Text] [PDF]

M. Kuzmanovic, V. J. Dudley, and V. P. Sarthy
GFAP Promoter Drives Muller Cell-Specific Expression in Transgenic Mice
Invest. Ophthalmol. Vis. Sci., August 1, 2003; 44(8): 3606 - 3613.
[Abstract] [Full Text] [PDF]

W. Kamitani, E. Ono, S. Yoshino, T. Kobayashi, S. Taharaguchi, B.-J. Lee, M. Yamashita, T. Kobayashi, M. Okamoto, H. Taniyama, et al.
Glial expression of Borna disease virus phosphoprotein induces behavioral and neurological abnormalities in transgenic mice
PNAS, July 22, 2003; 100(15): 8969 - 8974.
[Abstract] [Full Text] [PDF]

B. O. Kim, Y. Liu, Y. Ruan, Z. C. Xu, L. Schantz, and J. J. He
Neuropathologies in Transgenic Mice Expressing Human Immunodeficiency Virus Type 1 Tat Protein under the Regulation of the Astrocyte-Specific Glial Fibrillary Acidic Protein Promoter and Doxycycline
Am. J. Pathol., May 1, 2003; 162(5): 1693 - 1707.
[Abstract] [Full Text] [PDF]

N. A. Jensen, K. M. Pedersen, F. Lihme, L. Rask, J. V. Nielsen, T. E. Rasmussen, and C. Mitchelmore
Astroglial c-Myc Overexpression Predisposes Mice to Primary Malignant Gliomas
J. Biol. Chem., February 28, 2003; 278(10): 8300 - 8308.
[Abstract] [Full Text] [PDF]

N. Lochard, D. W. Silversides, J. P. van Kats, C. Mercure, and T. L. Reudelhuber
Brain-specific Restoration of Angiotensin II Corrects Renal Defects Seen in Angiotensinogen-deficient Mice
J. Biol. Chem., January 17, 2003; 278(4): 2184 - 2189.
[Abstract] [Full Text] [PDF]

V. Prevot, C. Rio, G. J. Cho, A. Lomniczi, S. Heger, C. M. Neville, N. A. Rosenthal, S. R. Ojeda, and G. Corfas
Normal Female Sexual Development Requires Neuregulin-erbB Receptor Signaling in Hypothalamic Astrocytes
J. Neurosci., January 1, 2003; 23(1): 230 - 239.
[Abstract] [Full Text] [PDF]

D. Huang, M. Tani, J. Wang, Y. Han, T. T. He, J. Weaver, I. F. Charo, V. K. Tuohy, B. J. Rollins, and R. M. Ransohoff
Pertussis Toxin-Induced Reversible Encephalopathy Dependent on Monocyte Chemoattractant Protein-1 Overexpression in Mice
J. Neurosci., December 15, 2002; 22(24): 10633 - 10642.
[Abstract] [Full Text] [PDF]

O. Stuve, S. Youssef, A. J. Slavin, C. L. King, J. C. Patarroyo, D. L. Hirschberg, W. J. Brickey, J. M. Soos, J. F. Piskurich, H. A. Chapman, et al.
The Role of the MHC Class II Transactivator in Class II Expression and Antigen Presentation by Astrocytes and in Susceptibility to Central Nervous System Autoimmune Disease
J. Immunol., December 15, 2002; 169(12): 6720 - 6732.
[Abstract] [Full Text] [PDF]

C. Zhu, Y. Zhang, and W. M. Pardridge
Widespread Expression of an Exogenous Gene in the Eye after Intravenous Administration
Invest. Ophthalmol. Vis. Sci., September 1, 2002; 43(9): 3075 - 3080.
[Abstract] [Full Text] [PDF]

S. Morimoto, M. D. Cassell, and C. D. Sigmund
Glia- and Neuron-specific Expression of the Renin-Angiotensin System in Brain Alters Blood Pressure, Water Intake, and Salt Preference
J. Biol. Chem., August 30, 2002; 277(36): 33235 - 33241.
[Abstract] [Full Text] [PDF]

I. Rozovsky, M. Wei, D. J. Stone, H. Zanjani, C. P. Anderson, T. E. Morgan, and C. E. Finch
Estradiol (E2) Enhances Neurite Outgrowth by Repressing Glial Fibrillary Acidic Protein Expression and Reorganizing Laminin
Endocrinology, February 1, 2002; 143(2): 636 - 646.
[Abstract] [Full Text] [PDF]

D. Nanda, R. Vogels, M. Havenga, C. J. Avezaat, A. Bout, and P. S. Smitt
Treatment of Malignant Gliomas with a Replicating Adenoviral Vector Expressing Herpes Simplex Virus-Thymidine Kinase
Cancer Res., December 1, 2001; 61(24): 8743 - 8750.
[Abstract] [Full Text] [PDF]

A. Cornet, T. C. Savidge, J. Cabarrocas, W.-L. Deng, J.-F. Colombel, H. Lassmann, P. Desreumaux, and R. S. Liblau
Enterocolitis induced by autoimmune targeting of enteric glial cells: A possible mechanism in Crohn's disease?
PNAS, October 25, 2001; (2001) 231474098.
[Abstract] [Full Text] [PDF]

N. Shi, Y. Zhang, C. Zhu, R. J. Boado, and W. M. Pardridge
Brain-specific expression of an exogenous gene after i.v. administration
PNAS, October 5, 2001; (2001) 221450098.
[Abstract] [Full Text] [PDF]

T. Shu and L. J. Richards
Cortical Axon Guidance by the Glial Wedge during the Development of the Corpus Callosum
J. Neurosci., April 15, 2001; 21(8): 2749 - 2758.
[Abstract] [Full Text] [PDF]

I. Tesseur, J. Van Dorpe, K. Spittaels, C. Van den Haute, D. Moechars, and F. Van Leuven
Expression of Human Apolipoprotein E4 in Neurons Causes Hyperphosphorylation of Protein Tau in the Brains of Transgenic Mice
Am. J. Pathol., March 1, 2000; 156(3): 951 - 964.
[Abstract] [Full Text] [PDF]

Y. H. Gong, A. S. Parsadanian, A. Andreeva, W. D. Snider, and J. L. Elliott
Restricted Expression of G86R Cu/Zn Superoxide Dismutase in Astrocytes Results in Astrocytosis But Does Not Cause Motoneuron Degeneration
J. Neurosci., January 15, 2000; 20(2): 660 - 665.
[Abstract] [Full Text] [PDF]

P Malatesta, E Hartfuss, and M Gotz
Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage
Development, January 12, 2000; 127(24): 5253 - 5263.
[Abstract] [PDF]

M. L. FELTRI, M. D'ANTONIO, S. PREVITALI, M. FASOLINI, A. MESSING, and L. WRABETZ
P0-Cre Transgenic Mice for Inactivation of Adhesion Molecules in Schwann Cells
Ann. N.Y. Acad. Sci., September 14, 1999; 883(1): 116 - 123.
[Abstract] [Full Text] [PDF]

M. Schinke, O. Baltatu, M. Bohm, J. Peters, W. Rascher, G. Bricca, A. Lippoldt, D. Ganten, and M. Bader
Blood pressure reduction and diabetes insipidus in transgenic rats deficient in brain angiotensinogen
PNAS, March 30, 1999; 96(7): 3975 - 3980.
[Abstract] [Full Text] [PDF]

A. Morelli, A. Larregina, J Smith-Arica, R. Dewey, T. Southgate, B Ambar, A Fontana, M. Castro, and P. Lowenstein
Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity
J. Gen. Virol., March 1, 1999; 80(3): 571 - 583.
[Abstract]

M. R. PICCIOTTO and K. WICKMAN
Using Knockout and Transgenic Mice to Study Neurophysiology and Behavior
Physiol Rev, October 1, 1998; 78(4): 1131 - 1163.
[Abstract] [Full Text] [PDF]

Y. Sun, S. Wu, G. Bu, M. K. Onifade, S. N. Patel, M. J. LaDu, A. M. Fagan, and D. M. Holtzman
Glial Fibrillary Acidic Protein-Apolipoprotein E (apoE) Transgenic Mice: Astrocyte-Specific Expression and Differing Biological Effects of Astrocyte-Secreted apoE3 and apoE4 Lipoproteins
J. Neurosci., May 1, 1998; 18(9): 3261 - 3272.
[Abstract] [Full Text] [PDF]

Q. T. Nguyen, A. S. Parsadanian, W. D. Snider, and J. W. Lichtman
Hyperinnervation of Neuromuscular Junctions Caused by GDNF Overexpression in Muscle
Science, March 13, 1998; 279(5357): 1725 - 1729.
[Abstract] [Full Text]

E. C. Holland and H. E. Varmus
Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer�in�mice
PNAS, February 3, 1998; 95(3): 1218 - 1223.
[Abstract] [Full Text] [PDF]

R. Awatramani, S. Scherer, J. Grinspan, E. Collarini, R. Skoff, D. O'Hagan, J. Garbern, and J. Kamholz
Evidence That the Homeodomain Protein Gtx Is Involved in the Regulation of Oligodendrocyte Myelination
J. Neurosci., September 1, 1997; 17(17): 6657 - 6668.
[Abstract] [Full Text] [PDF]

C. L. Delaney, M. Brenner, and A. Messing
Conditional Ablation of Cerebellar Astrocytes in Postnatal Transgenic Mice
J. Neurosci., November 1, 1996; 16(21): 6908 - 6918.
[Abstract] [Full Text] [PDF]

M. Schinke, M. Bohm, G. Bricca, D. Ganten, and M. Bader
Permanent Inhibition of Angiotensinogen Synthesis by Antisense RNA Expression
Hypertension, March 1, 1996; 27(3): 508 - 513.
[Abstract] [Full Text]

N. Shi, Y. Zhang, C. Zhu, R. J. Boado, and W. M. Pardridge
Brain-specific expression of an exogenous gene after i.v. administration
PNAS, October 23, 2001; 98(22): 12754 - 12759.
[Abstract] [Full Text] [PDF]

A. Cornet, T. C. Savidge, J. Cabarrocas, W.-L. Deng, J.-F. Colombel, H. Lassmann, P. Desreumaux, and R. S. Liblau
Enterocolitis induced by autoimmune targeting of enteric glial cells: A possible mechanism in Crohn's disease?
PNAS, November 6, 2001; 98(23): 13306 - 13311.
[Abstract] [Full Text] [PDF]

S. Morimoto, M. D. Cassell, T. G. Beltz, A. K. Johnson, R. L. Davisson, and C. D. Sigmund
Elevated Blood Pressure in Transgenic Mice With Brain-Specific Expression of Human Angiotensinogen Driven by the Glial Fibrillary Acidic Protein Promoter
Circ. Res., August 17, 2001; 89(4): 365 - 372.
[Abstract] [Full Text] [PDF]