 |
Previous Article | Next Article 
Journal of Neuroscience, Vol 14, 1395-1412, Copyright © 1994 by Society for Neuroscience
Roles of Pax-genes in developing and adult brain as suggested by expression patterns
A Stoykova and P Gruss
Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany.
We have examined the transcript distribution of six members of the murine
paired box-containing gene family (Pax-gene family) in midgestation embryo
and adult brain using in situ hybridization analysis. The expression
domains of several Pax-genes in the embryo brain were found to correspond
with anatomical boundaries that coincide with neuromere landmarks and
therefore respect former neuromere territories in the forebrain. The
results are consistent with the concept of brain segmentation and suggest a
role for Pax-genes in the brain regionalization. In the adult brain the
expression of Pax-genes was observed in discreet areas, with a caudal to
rostral restriction in the number of the expressed genes. In general the
distribution of transcripts along the anterior-posterior axis was similar
to that found in midgestation embryo brain, suggesting a role for Pax-genes
in the commitment of the precursor cells to different neuronal cell fates
and in the maintenance of specific brain cell subtypes. In the cerebellar
cortex, the granular cell layer was found to express high levels of the
Pax-6 gene, while putative Bergmann glia and cells surrounding the Purkinje
cells contained Pax-3 transcripts. The main adult brain structures that
expressed distinct Pax-mRNAs were the periglomerular and granular cell
layer of olfactory bulb, nuclei of the septum, amygdala, and isthmus, which
suggests a role for the Pax-gene family in the specification of the
subcortical domains of the evolutionary old limbic system.
This article has been cited by other articles:

|
 |

|
 |
 
S. Boretius, T. Michaelis, R. Tammer, R. Ashery-Padan, J. Frahm, and A. Stoykova
In Vivo MRI of Altered Brain Anatomy and Fiber Connectivity in Adult Pax6 Deficient Mice
Cereb Cortex,
December 1, 2009;
19(12):
2838 - 2847.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. N. Sansom and F. J. Livesey
Gradients in the Brain: The Control of the Development of Form and Function in the Cerebral Cortex
Cold Spring Harb Perspect Biol,
August 1, 2009;
1(2):
a002519 - a002519.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. C. Tuoc, K. Radyushkin, A. B. Tonchev, M. C. Pinon, R. Ashery-Padan, Z. Molnar, M. S. Davidoff, and A. Stoykova
Selective Cortical Layering Abnormalities and Behavioral Deficits in Cortex-Specific Pax6 Knock-Out Mice
J. Neurosci.,
July 1, 2009;
29(26):
8335 - 8349.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. S.E. Carney, L. A. Cocas, T. Hirata, K. Mansfield, and J. G. Corbin
Differential Regulation of Telencephalic Pallial-Subpallial Boundary Patterning by Pax6 and Gsh2
Cereb Cortex,
April 1, 2009;
19(4):
745 - 759.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. Dietrich, R. Shanmugasundaram, S. E, and I. Dragatsis
Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages
Hum. Mol. Genet.,
January 1, 2009;
18(1):
142 - 150.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. C. Havrda, B. T. Harris, A. Mantani, N. M. Ward, B. R. Paolella, V. C. Cuzon, H. H. Yeh, and M. A. Israel
Id2 Is Required for Specification of Dopaminergic Neurons during Adult Olfactory Neurogenesis
J. Neurosci.,
December 24, 2008;
28(52):
14074 - 14087.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Alvarez-Buylla, M. Kohwi, T.M. Nguyen, and F.T. Merkle
The Heterogeneity of Adult Neural Stem Cells and the Emerging Complexity of Their Niche
Cold Spring Harb Symp Quant Biol,
November 6, 2008;
(2008)
sqb.2008.73.019v1.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
R. B. White and M. R. Ziman
Genome-wide discovery of Pax7 target genes during development
Physiol Genomics,
October 8, 2008;
33(1):
41 - 49.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. C. Pinon, T. C. Tuoc, R. Ashery-Padan, Z. Molnar, and A. Stoykova
Altered Molecular Regionalization and Normal Thalamocortical Connections in Cortex-Specific Pax6 Knock-Out Mice
J. Neurosci.,
August 27, 2008;
28(35):
8724 - 8734.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
I. Vulih-Shultzman, A. Pinhasov, S. Mandel, N. Grigoriadis, O. Touloumi, Z. Pittel, and I. Gozes
Activity-Dependent Neuroprotective Protein Snippet NAP Reduces Tau Hyperphosphorylation and Enhances Learning in a Novel Transgenic Mouse Model
J. Pharmacol. Exp. Ther.,
November 1, 2007;
323(2):
438 - 449.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. Tamai, H. Shinohara, T. Miyata, K. Saito, Y. Nishizawa, T. Nomura, and N. Osumi
Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells
Genes Cells,
September 1, 2007;
12(9):
983 - 996.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Miquelajauregui, T. Van de Putte, A. Polyakov, A. Nityanandam, S. Boppana, E. Seuntjens, A. Karabinos, Y. Higashi, D. Huylebroeck, and V. Tarabykin
Smad-interacting protein-1 (Zfhx1b) acts upstream of Wnt signaling in the mouse hippocampus and controls its formation
PNAS,
July 31, 2007;
104(31):
12919 - 12924.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. E. Long, S. Garel, M. Alvarez-Dolado, K. Yoshikawa, N. Osumi, A. Alvarez-Buylla, and J. L. R. Rubenstein
Dlx-Dependent and -Independent Regulation of Olfactory Bulb Interneuron Differentiation
J. Neurosci.,
March 21, 2007;
27(12):
3230 - 3243.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Inan and M. C. Crair
Development of Cortical Maps: Perspectives From the Barrel Cortex
Neuroscientist,
February 1, 2007;
13(1):
49 - 61.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
D. A. Mayes, Y. Hu, Y. Teng, E. Siegel, X. Wu, K. Panda, F. Tan, W.K. A. Yung, and Y.-H. Zhou
PAX6 Suppresses the Invasiveness of Glioblastoma Cells and the Expression of the Matrix Metalloproteinase-2 Gene.
Cancer Res.,
October 15, 2006;
66(20):
9809 - 9817.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Hirata, M. Nakazawa, O. Muraoka, R. Nakayama, Y. Suda, and M. Hibi
Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions
Development,
October 15, 2006;
133(20):
3993 - 4004.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
V. Fotaki, T. Yu, P. A. Zaki, J. O. Mason, and D. J. Price
Abnormal Positioning of Diencephalic Cell Types in Neocortical Tissue in the Dorsal Telencephalon of Mice Lacking Functional Gli3
J. Neurosci.,
September 6, 2006;
26(36):
9282 - 9292.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. C. Hu, R. Mo, S. Bhella, C. W. Wilson, P.-T. Chuang, C.-c. Hui, and N. D. Rosenblum
GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis
Development,
February 1, 2006;
133(3):
569 - 578.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Sur and J. L. R. Rubenstein
Patterning and Plasticity of the Cerebral Cortex
Science,
November 4, 2005;
310(5749):
805 - 810.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
O. Grinchuk, Z. Kozmik, X. Wu, and S. Tomarev
The Optimedin Gene Is a Downstream Target of Pax6
J. Biol. Chem.,
October 21, 2005;
280(42):
35228 - 35237.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y. Arai, N. Funatsu, K. Numayama-Tsuruta, T. Nomura, S. Nakamura, and N. Osumi
Role of Fabp7, a Downstream Gene of Pax6, in the Maintenance of Neuroepithelial Cells during Early Embryonic Development of the Rat Cortex
J. Neurosci.,
October 19, 2005;
25(42):
9752 - 9761.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Maekawa, N. Takashima, Y. Arai, T. Nomura, K. Inokuchi, S. Yuasa, and N. Osumi
Pax6 is required for production and maintenance of progenitor cells in postnatal hippocampal neurogenesis
Genes Cells,
October 1, 2005;
10(10):
1001 - 1014.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. L. Hagemann, S. A. Gaeta, M. A. Smith, D. A. Johnson, J. A. Johnson, and A. Messing
Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction
Hum. Mol. Genet.,
August 15, 2005;
14(16):
2443 - 2458.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Kohwi, N. Osumi, J. L. R. Rubenstein, and A. Alvarez-Buylla
Pax6 Is Required for Making Specific Subpopulations of Granule and Periglomerular Neurons in the Olfactory Bulb
J. Neurosci.,
July 27, 2005;
25(30):
6997 - 7003.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. Nishioka, S. Nagano, R. Nakayama, H. Kiyonari, T. Ijiri, K. Taniguchi, W. Shawlot, Y. Hayashizaki, H. Westphal, R. R. Behringer, et al.
Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex
Development,
June 1, 2005;
132(11):
2535 - 2546.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. T. Kroll and D. D. M. O'Leary
Ventralized dorsal telencephalic progenitors in Pax6 mutant mice generate GABA interneurons of a lateral ganglionic eminence fate
PNAS,
May 17, 2005;
102(20):
7374 - 7379.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Wernig, F. Benninger, T. Schmandt, M. Rade, K. L. Tucker, H. Bussow, H. Beck, and O. Brustle
Functional Integration of Embryonic Stem Cell-Derived Neurons In Vivo
J. Neurosci.,
June 2, 2004;
24(22):
5258 - 5268.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Nomura and N. Osumi
Misrouting of mitral cell progenitors in the Pax6/small eyerat telencephalon
Development,
February 15, 2004;
131(4):
787 - 796.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. W. Land and A. P. Monaghan
Expression of the Transcription Factor, tailless, Is Required for Formation of Superficial Cortical Layers
Cereb Cortex,
September 1, 2003;
13(9):
921 - 931.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Bach, Y. Lallemand, M.-A. Nicola, C. Ramos, L. Mathis, M. Maufras, and B. Robert
Msx1 is required for dorsal diencephalon patterning
Development,
September 1, 2003;
130(17):
4025 - 4036.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. A. Tyas, H. Pearson, P. Rashbass, and D. J. Price
Pax6 Regulates Cell Adhesion during Cortical Development
Cereb Cortex,
June 1, 2003;
13(6):
612 - 619.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Leingartner, L. J. Richards, R. H. Dyck, C. Akazawa, and D. D.M. O'Leary
Cloning and Cortical Expression of Rat Emx2 and Adenovirus-mediated Overexpression to Assess its Regulation of Area-specific Targeting of Thalamocortical Axons
Cereb Cortex,
June 1, 2003;
13(6):
648 - 660.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Garel, K. J. Huffman, and J. L. R. Rubenstein
Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants
Development,
May 1, 2003;
130(9):
1903 - 1914.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Estivill-Torrus, H. Pearson, V. van Heyningen, D. J. Price, and P. Rashbass
Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors
Development,
March 3, 2003;
129(2):
455 - 466.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. E. Long, S. Garel, M. J. Depew, S. Tobet, and J. L. R. Rubenstein
DLX5 Regulates Development of Peripheral and Central Components of the Olfactory System
J. Neurosci.,
January 15, 2003;
23(2):
568 - 578.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. Skala-Rubinson, J. Vinh, V. Labas, A. Kahn, and F. P. D. Tuy
Novel Target Sequences for Pax-6 in the Brain-specific Activating Regions of the Rat Aldolase C Gene
J. Biol. Chem.,
November 27, 2002;
277(49):
47190 - 47196.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. Dreuillet, J. Tillit, M. Kress, and M. Ernoult-Lange
In vivo and in vitro interaction between human transcription factor MOK2 and nuclear lamin A/C
Nucleic Acids Res.,
November 1, 2002;
30(21):
4634 - 4642.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. M. Bishop, J. L. R. Rubenstein, and D. D. M. O'Leary
Distinct Actions of Emx1, Emx2, and Pax6 in Regulating the Specification of Areas in the Developing Neocortex
J. Neurosci.,
September 1, 2002;
22(17):
7627 - 7638.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Goudreau, P. Petrou, L. W. Reneker, J. Graw, J. Loster, and P. Gruss
Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype
PNAS,
June 25, 2002;
99(13):
8719 - 8724.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. Jones, G. Lopez-Bendito, P. Gruss, A. Stoykova, and Z. Molnar
Pax6 is required for the normal development of the forebrain axonal connections
Development,
January 11, 2002;
129(21):
5041 - 5052.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. V. Dimanlig, S. C. Faber, W. Auerbach, H. P. Makarenkova, and R. A. Lang
The upstream ectoderm enhancer in Pax6 has an important role in lens induction
Development,
November 15, 2001;
128(22):
4415 - 4424.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y. Murakami, M. Ogasawara, F. Sugahara, S. Hirano, N. Satoh, and S. Kuratani
Identification and expression of the lamprey Pax6 gene: evolutionary origin of the segmented brain of vertebrates
Development,
September 15, 2001;
128(18):
3521 - 3531.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. A. Kleinjan, A. Seawright, A. Schedl, R. A Quinlan, S. Danes, and V. van Heyningen
Aniridia-associated translocations, DNase hypersensitivity, sequence comparison and transgenic analysis redefine the functional domain of PAX6
Hum. Mol. Genet.,
September 1, 2001;
10(19):
2049 - 2059.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Yamasaki, K. Kawaji, K. Ono, H. Bito, T. Hirano, N. Osumi, and M. Kengaku
Pax6 regulates granule cell polarization during parallel fiber formation in the developing cerebellum
Development,
August 15, 2001;
128(16):
3133 - 3144.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
V. Tarabykin, A. Stoykova, N. Usman, and P. Gruss
Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression
Development,
June 1, 2001;
128(11):
1983 - 1993.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y. Nakagawa and D. D. M. O'Leary
Combinatorial Expression Patterns of LIM-Homeodomain and Other Regulatory Genes Parcellate Developing Thalamus
J. Neurosci.,
April 15, 2001;
21(8):
2711 - 2725.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Stoykova, D. Treichel, M. Hallonet, and P. Gruss
Pax6 Modulates the Dorsoventral Patterning of the Mammalian Telencephalon
J. Neurosci.,
November 1, 2000;
20(21):
8042 - 8050.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Ashery-Padan, T. Marquardt, X. Zhou, and P. Gruss
Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
Genes & Dev.,
November 1, 2000;
14(21):
2701 - 2711.
[Abstract]
[Full Text]
|
 |
|

|
 |

|
 |
 
Q. Liu, N. D. Dwyer, and D. D. M. O'Leary
Differential Expression of COUP-TFI, CHL1, and Two Novel Genes in Developing Neocortex Identified by Differential Display PCR
J. Neurosci.,
October 15, 2000;
20(20):
7682 - 7690.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. M. Bishop, G. Goudreau, and D. D. O'Leary
Regulation of Area Identity in the Mammalian Neocortex by Emx2 and Pax6
Science,
April 14, 2000;
288(5464):
344 - 349.
[Abstract]
[Full Text]
|
 |
|

|
 |

|
 |
 
H. B. Samat and J. H. Menkes
How to Construct a Neural Tube
J Child Neurol,
February 1, 2000;
15(2):
110 - 124.
[PDF]
|
 |
|

|
 |

|
 |
 
T Pratt, T Vitalis, N Warren, J. Edgar, J. Mason, and D. Price
A role for Pax6 in the normal development of dorsal thalamus and its cortical connections
Development,
January 12, 2000;
127(23):
5167 - 5178.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
M Schwarz, F Cecconi, G Bernier, N Andrejewski, B Kammandel, M Wagner, and P Gruss
Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6
Development,
January 10, 2000;
127(20):
4325 - 4334.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
P Daubas, S Tajbakhsh, J Hadchouel, M Primig, and M Buckingham
Myf5 is a novel early axonal marker in the mouse brain and is subjected to post-transcriptional regulation in neurons
Development,
January 1, 2000;
127(2):
319 - 331.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
N. Warren, D. Caric, T. Pratt, J. A. Clausen, P. Asavaritikrai, J. O. Mason, R. E. Hill, and D. J. Price
The Transcription Factor, Pax6, is Required for Cell Proliferation and Differentiation in the Developing Cerebral Cortex
Cereb Cortex,
September 1, 1999;
9(6):
627 - 635.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Beimesche, A. Neubauer, S. Herzig, R. Grzeskowiak, T. Diedrich, I. Cierny, D. Scholz, T. Alejel, and W. Knepel
Tissue-Specific Transcriptional Activity of a Pancreatic Islet Cell-Specific Enhancer Sequence/Pax6-Binding Site Determined in Normal Adult Tissues in Vivo Using Transgenic Mice
Mol. Endocrinol.,
May 1, 1999;
13(5):
718 - 728.
[Abstract]
[Full Text]
|
 |
|

|
 |

|
 |
 
D Engelkamp, P Rashbass, A Seawright, and V van Heyningen
Role of Pax6 in development of the cerebellar system
Development,
January 8, 1999;
126(16):
3585 - 3596.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
M Hidalgo-Sanchez, A Simeone, and R. Alvarado-Mallart
Fgf8 and Gbx2 induction concomitant with Otx2 repression is correlated with midbrain-hindbrain fate of caudal prosencephalon
Development,
January 6, 1999;
126(14):
3191 - 3203.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Torii, F Matsuzaki, N Osumi, K Kaibuchi, S Nakamura, S Casarosa, F Guillemot, and M Nakafuku
Transcription factors Mash-1 and Prox-1 delineate early steps in differentiation of neural stem cells in the developing central nervous system
Development,
January 2, 1999;
126(3):
443 - 456.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
J. C. Lin and C. L. Cepko
Granule Cell Raphes and Parasagittal Domains of Purkinje Cells: Complementary Patterns in the Developing Chick Cerebellum
J. Neurosci.,
November 15, 1998;
18(22):
9342 - 9353.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. Jones, Y. Kuo, Y. Sun, and S. Beckendorf
The Drosophila Pax gene eye gone is required for embryonic salivary duct development
Development,
January 11, 1998;
125(21):
4163 - 4174.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
M Hallonet, T Hollemann, R Wehr, N. Jenkins, N. Copeland, T Pieler, and P Gruss
Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain
Development,
January 7, 1998;
125(14):
2599 - 2610.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
S Glardon, L. Holland, W. Gehring, and N. Holland
Isolation and developmental expression of the amphioxus Pax-6 gene (AmphiPax-6): insights into eye and photoreceptor evolution
Development,
January 7, 1998;
125(14):
2701 - 2710.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Fernandez, C Pieau, J Reperant, E Boncinelli, and M Wassef
Expression of the Emx-1 and Dlx-1 homeobox genes define three molecularly distinct domains in the telencephalon of mouse, chick, turtle and frog embryos: implications for the evolution of telencephalic subdivisions in amniotes
Development,
January 6, 1998;
125(11):
2099 - 2111.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Schwarz, G. Alvarez-Bolado, P. Urbanek, M. Busslinger, and P. Gruss
Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: Evidence from targeted mutations
PNAS,
December 23, 1997;
94(26):
14518 - 14523.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
E. S. Massuda, E. J. Dunphy, R. A. Redman, J. J. Schreiber, L. E. Nauta, F. G. Barr, I. H. Maxwell, and T. P. Cripe
Regulated expression of the diphtheria toxin A chain by a tumor-specific chimeric transcription factor results in selective toxicity for alveolar rhabdomyosarcoma cells
PNAS,
December 23, 1997;
94(26):
14701 - 14706.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. S. A. van Schaick, M. P. Smidt, A. C. Rovescalli, M. Luijten, A. A. M. van der Kleij, S. Asoh, C. A. Kozak, M. Nirenberg, and J. P. H. Burbach
Homeobox gene Prx3 expression in rodent brain and extraneural tissues
PNAS,
November 25, 1997;
94(24):
12993 - 12998.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D Caric, D Gooday, R. Hill, S. McConnell, and D. Price
Determination of the migratory capacity of embryonic cortical cells lacking the transcription factor Pax-6
Development,
January 12, 1997;
124(24):
5087 - 5096.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
R Wehr, A Mansouri, T de Maeyer, and P Gruss
Fkh5-deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body
Development,
January 11, 1997;
124(22):
4447 - 4456.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
A Stoykova, M Gotz, P Gruss, and J Price
Pax6-dependent regulation of adhesive patterning, R-cadherin expression and boundary formation in developing forebrain
Development,
January 10, 1997;
124(19):
3765 - 3777.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
D Acampora, V Avantaggiato, F Tuorto, and A Simeone
Genetic control of brain morphogenesis through Otx gene dosage requirement
Development,
January 9, 1997;
124(18):
3639 - 3650.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
N Osumi, A Hirota, H Ohuchi, M Nakafuku, T Iimura, S Kuratani, M Fujiwara, S Noji, and K Eto
Pax-6 is involved in the specification of hindbrain motor neuron subtype
Development,
January 8, 1997;
124(15):
2961 - 2972.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Mastick, N. Davis, G. Andrew, and S. Easter
Pax-6 functions in boundary formation and axon guidance in the embryonic mouse forebrain
Development,
January 5, 1997;
124(10):
1985 - 1997.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
N Warren and D. Price
Roles of Pax-6 in murine diencephalic development
Development,
January 4, 1997;
124(8):
1573 - 1582.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
P Kury, N Schaeren-Wiemers, and D Monard
Protease nexin-1 is expressed at the mouse met-/mesencephalic junction and FGF signaling regulates its promoter activity in primary met-/mesencephalic cells
Development,
January 3, 1997;
124(6):
1251 - 1262.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
M Brand, C. Heisenberg, Y. Jiang, D Beuchle, K Lun, M Furutani-Seiki, M Granato, P Haffter, M Hammerschmidt, D. Kane, et al.
Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain
Development,
January 12, 1996;
123(1):
179 - 190.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
M Pellegrini, A Mansouri, A Simeone, E Boncinelli, and P Gruss
Dentate gyrus formation requires Emx2
Development,
January 12, 1996;
122(12):
3893 - 3898.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
A Stoykova, R Fritsch, C Walther, and P Gruss
Forebrain patterning defects in Small eye mutant mice
Development,
January 11, 1996;
122(11):
3453 - 3465.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
Y Nakagawa, T Kaneko, T Ogura, T Suzuki, M Torii, K Kaibuchi, K Arai, S Nakamura, and M Nakafuku
Roles of cell-autonomous mechanisms for differential expression of region-specific transcription factors in neuroepithelial cells
Development,
January 8, 1996;
122(8):
2449 - 2464.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
P Tremblay, F Pituello, and P Gruss
Inhibition of floor plate differentiation by Pax3: evidence from ectopic expression in transgenic mice
Development,
January 8, 1996;
122(8):
2555 - 2567.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
A Mansouri, A Stoykova, M Torres, and P Gruss
Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant mice
Development,
January 3, 1996;
122(3):
831 - 838.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
K Shimamura, D. Hartigan, S Martinez, L Puelles, and J. Rubenstein
Longitudinal organization of the anterior neural plate and neural tube
Development,
January 12, 1995;
121(12):
3923 - 3933.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
K. Millen, C. Hui, and A. Joyner
A role for En-2 and other murine homologues of Drosophila segment polarity genes in regulating positional information in the developing cerebellum
Development,
January 12, 1995;
121(12):
3935 - 3945.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
G Oliver, A Mailhos, R Wehr, N. Copeland, N. Jenkins, and P Gruss
Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development
Development,
January 12, 1995;
121(12):
4045 - 4055.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
J. Rubenstein, S Martinez, K Shimamura, and L Puelles
The embryonic vertebrate forebrain: the prosomeric model
Science,
October 28, 1994;
266(5185):
578 - 580.
[PDF]
|
 |
|

|
 |

|
 |
 
P. T. Schwartz, B. Perez-Villamil, A. Rivera, R. Moratalla, and M. Vallejo
Pancreatic Homeodomain Transcription Factor IDX1/IPF1 Expressed in Developing Brain Regulates Somatostatin Gene Transcription in Embryonic Neural Cells
J. Biol. Chem.,
June 16, 2000;
275(25):
19106 - 19114.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
V. Arranz, C. Dreuillet, P. Crisanti, J. Tillit, M. Kress, and M. Ernoult-Lange
The Zinc Finger Transcription Factor, MOK2, Negatively Modulates Expression of the Interphotoreceptor Retinoid-binding Protein Gene, IRBP
J. Biol. Chem.,
April 6, 2001;
276(15):
11963 - 11969.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y. Shimoda, Y. Tajima, T. Osanai, A. Katsume, M. Kohara, T. Kudo, H. Narimatsu, N. Takashima, Y. Ishii, S. Nakamura, et al.
Pax6 Controls the Expression of Lewis x Epitope in the Embryonic Forebrain by Regulating alpha 1,3-Fucosyltransferase IX Expression
J. Biol. Chem.,
January 11, 2002;
277(3):
2033 - 2039.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Kurusu, T. Nagao, U. Walldorf, S. Flister, W. J. Gehring, and K. Furukubo-Tokunaga
Genetic control of development of the mushroom bodies, the associative learning centers in the Drosophila brain, by the eyeless, twin of eyeless, and dachshund genes
PNAS,
February 29, 2000;
97(5):
2140 - 2144.
[Abstract]
[Full Text]
[PDF]
|
 |
|
|

|