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Journal of Neuroscience, Vol 14, 1413-1421, Copyright © 1994 by Society for Neuroscience
Decrease in growth cone-neurite fasciculation by sensory or motor cells in vitro accompanies downregulation of Aplysia cell adhesion molecules by neurotransmitters
N Peter, B Aronoff, F Wu and S Schacher
Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York.
Cell adhesion molecules play important roles in axon guidance and synapse
formation. Recent studies suggest that the expression of some of these
molecules can be regulated either by electrical activity or by specific
neurotransmitters. The expression of neural cell adhesion molecule
(NCAM)-like molecules in Aplysia, designated apCAM, is downregulated from
the surface of sensory neurons by 5-HT, a transmitter known to evoke
long-term changes in the structure and function of these neurons. We tested
whether the distribution of apCAM on the surface of other neurons can be
regulated by treatments with other neurotransmitters known to evoke
long-term functional and structural changes in Aplysia neurons, and we
examined the consequences of treatments with the neurotransmitters on the
pattern of growth cone- neurite interactions. We report that applications
of the neuropeptide Phe-Met-Arg-Phe-amide (FMRFamide) that evoke long-term
synaptic depression also reduce apCAM expression on the surface of motor
cell L7 via a mechanism that appears to be similar to the mechanism
mediating the 5-HT-induced change in the sensory cells. Specific treatments
that affect apCAM distribution on the surface of their respective cells, 5-
HT on sensory cells or FMRFamide on motor cell L7, mimic treatment with
monoclonal antibodies against apCAM by evoking a significant reduction in
the fasciculation of growth cones with other neurites extending from
homologous cells.(ABSTRACT TRUNCATED AT 250 WORDS)
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