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Journal of Neuroscience, Vol 14, 1441-1449, Copyright © 1994 by Society for Neuroscience
Optic nerve injury alters basic fibroblast growth factor localization in the retina and optic tract
SK Kostyk, PA D'Amore, IM Herman and JA Wagner
Department of Surgical Research, Children's Hospital, Boston, Massachusetts 02114.
Basic fibroblast growth factor (bFGF) is thought to be a trophic factor for
several classes of neurons. Its distribution changes in response to
cortical neural injury. We have determined the effect of injury to the
optic nerve on localization of bFGF in the rodent retina and visual
pathways. Our observations were confirmed by using different antisera and
monoclonal antibodies. While photoreceptors normally contain virtually no
bFGF, crushing the optic nerve causes a striking increase, over a period of
several weeks, in the amount of bFGF in retinal photoreceptors. Since
photoreceptors do not synapse directly upon the injured ganglion cells,
intermediary cells must participate in the cascade of events that results
in the elevated bFGF. In light of the observation that exogenous bFGF
protects photoreceptors from photodamage (Faktorovich et al., 1992), this
increase in bFGF in photoreceptors may explain, in part, why crushing the
optic nerve protects photorecptors against photodamage (Bush and Williams,
1991). Whereas bFGF is constitutively found in glia in the optic nerve,
little bFGF is found in glia in the optic tract. However, damage to the
optic nerve increases bFGF in astrocytes in the optic tract. This change
occurs within days, suggesting that a relatively direct signal may
intervene between the injured axon and the adjacent glial cells. Thus,
despite the fact that the optic nerve and optic tract are contiguous
structures through which axons of retinal ganglion cells project, the glial
elements in these structures express distinct properties, because of
differences in either glial subclasses or microenvironment.(ABSTRACT
TRUNCATED AT 250 WORDS)
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