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 Previous Article
Journal of Neuroscience, Vol 14, 1856-1877, Copyright © 1994 by Society for Neuroscience
Topographic organization of the reciprocal connections between the monkey entorhinal cortex and the perirhinal and parahippocampal cortices
WA Suzuki and DG Amaral
Group in Neurosciences, University of California at San Diego, La Jolla 92093.
The perirhinal and parahippocampal cortices constitute the major sources of
cortical input to the monkey entorhinal cortex. Neuropsychological studies
have shown that these three cortical regions contribute in an important way
to normal memory function. We have investigated the topographic and laminar
organization of the reciprocal projections between the entorhinal cortex
and these two adjacent cortical areas by placing anterograde and retrograde
tracers in all three regions. There were three major findings. First, the
perirhinal and parahippocampal cortices have distinct but partially
overlapping interconnections with the entorhinal cortex. The perirhinal
cortex tends to be interconnected with the rostral two-thirds of the
entorhinal cortex while the parahippocampal cortex tends to be
interconnected with approximately the caudal two-thirds of the entorhinal
cortex. Second, the degree of reciprocity of the interconnections of the
entorhinal cortex with the perirhinal and parahippocampal cortices differs.
The parahippocampal/entorhinal connections have a high degree of
reciprocity. In contrast, the degree of reciprocity of the
perirhinal/entorhinal interconnections varies depending on the mediolateral
position within the perirhinal cortex; medial portions of the perirhinal
cortex exhibit a higher degree of reciprocity with the entorhinal cortex
than lateral portions. Third, the projections from the perirhinal and
parahippocampal cortices to the entorhinal cortex resemble a feedforward
projection, while the projections from the entorhinal cortex to the
perirhinal and parahippocampal cortices resemble a feedback projection
pattern.
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