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Journal of Neuroscience, Vol 14, 1930-1942, Copyright © 1994 by Society for Neuroscience
Axons regulate Schwann cell expression of the POU transcription factor SCIP
SS Scherer, DY Wang, R Kuhn, G Lemke, L Wrabetz and J Kamholz
Department of Neurology, Hospital of University of Pennsylvania, Philadelphia 19104.
SCIP (suppressed cAMP-inducible POU) is a POU domain transcription factor
expressed by Schwann cells. Drugs that elevate intracellular cAMP, such as
forskolin, increase the expression of SCIP and partially mimic the
inductive effects of axons on Schwann cell gene expression. Thus, SCIP may
be involved in a differentiation pathway in Schwann cells that is activated
by axons. We have examined this issue by studying SCIP expression in
developing, degenerating, and regenerating rat peripheral nerves, and in
Schwann cell-neuron cocultures. High levels of SCIP mRNA were detected in
developing and regenerating nerves, and axotomy at these times caused the
level of SCIP mRNA to plummet. Similarly, there were many
SCIP-immunoreactive Schwann cell nuclei in developing and regenerating
nerves, and their number fell sharply after axotomy. SCIP-immunoreactive
Schwann cells were associated with axons in developing and regenerating
nerves, and in Schwann cell-neuron cocultures. These data demonstrate that
axons upregulate the expression of SCIP in Schwann cells, and that SCIP is
expressed in Schwann cells that ensheathe axons. Thus, SCIP may mediate
some of the changes in Schwann cell gene expression that accompany axonal
ensheathment.
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