 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 14, 1978-1984, Copyright © 1994 by Society for Neuroscience
Self-administration of morphine, DAMGO, and DPDPE into the ventral tegmental area of rats
DP Devine and RA Wise
Department of Psychology, Concordia University, Montreal, Quebec, Canada.
Intracranial self-administration of mu- and delta-opioid agonists was
demonstrated in male Long-Evans rats. Independent groups were allowed to
lever-press for ventral tegmental area (VTA) microinfusions of morphine,
the selective mu agonist [D-Ala2,N-Me-Phe4-Gly5-ol]- enkephalin (DAMGO),
the selective delta-agonist [D-Pen2,D-Pen5]- enkephalin (DPDPE), or
ineffective drug vehicle. Morphine, DAMGO, and DPDPE were each effective in
establishing and maintaining lever- pressing habits. Lever-pressing
responses were extinguished during a session when vehicle was substituted
for drug, and reinstated when drug reinforcement was reestablished. Thus,
it appears that VTA mu- and delta-opioid receptors are each involved in
reinforcement of opiate self-administration. The effective dose of
DAMGO--both for establishing and for maintaining the lever-press habit--was
100 times lower than the effective doses for DPDPE and morphine, suggesting
that the major contribution of VTA mechanisms to intravenous heroin self-
administration involves an action on mu-opioid receptors.
This article has been cited by other articles:
|
|
|
|
 
J. P. Britt and D. S. McGehee
Presynaptic Opioid and Nicotinic Receptor Modulation of Dopamine Overflow in the Nucleus Accumbens
J. Neurosci.,
February 13, 2008;
28(7):
1672 - 1681.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. M. Jutkiewicz, M. G. Baladi, J. E. Folk, K. C. Rice, and J. H. Woods
The {delta}-Opioid Receptor Agonist SNC80 [(+)-4-[{alpha}(R)-{alpha}-[(2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl]-(3-methoxybenzyl)-N,N-diethylbenzamide] Synergistically Enhances the Locomotor-Activating Effects of Some Psychomotor Stimulants, but Not Direct Dopamine Agonists, in Rats
J. Pharmacol. Exp. Ther.,
February 1, 2008;
324(2):
714 - 724.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Beguin, D. N. Potter, J. A. DiNieri, T. A. Munro, M. R. Richards, T. A. Paine, L. Berry, Z. Zhao, B. L. Roth, W. Xu, et al.
N-Methylacetamide Analog of Salvinorin A: A Highly Potent and Selective {kappa}-Opioid Receptor Agonist with Oral Efficacy
J. Pharmacol. Exp. Ther.,
January 1, 2008;
324(1):
188 - 195.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. A. Rodd, V. E. Gryszowka, J. E. Toalston, S. M. Oster, D. Ji, R. L. Bell, and W. J. McBride
The Reinforcing Actions of a Serotonin-3 Receptor Agonist within the Ventral Tegmental Area: Evidence for Subregional and Genetic Differences and Involvement of Dopamine Neurons
J. Pharmacol. Exp. Ther.,
June 1, 2007;
321(3):
1003 - 1012.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Fichna, A. Janecka, J. Costentin, and J.-C. Do Rego
The Endomorphin System and Its Evolving Neurophysiological Role
Pharmacol. Rev.,
March 1, 2007;
59(1):
88 - 123.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Zangen, M. Solinas, S. Ikemoto, S. R. Goldberg, and R. A. Wise
Two brain sites for cannabinoid reward.
J. Neurosci.,
May 3, 2006;
26(18):
4901 - 4907.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. M. Jutkiewicz, S. T. Kaminsky, K. C. Rice, J. R. Traynor, and J. H. Woods
Differential Behavioral Tolerance to the {delta}-Opioid Agonist SNC80 ([(+)-4-[({alpha}R)-{alpha}-[(2S,5R)-2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in Sprague-Dawley Rats
J. Pharmacol. Exp. Ther.,
October 1, 2005;
315(1):
414 - 422.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ikemoto, B. M. Witkin, A. Zangen, and R. A. Wise
Rewarding Effects of AMPA Administration into the Supramammillary or Posterior Hypothalamic Nuclei But Not the Ventral Tegmental Area
J. Neurosci.,
June 23, 2004;
24(25):
5758 - 5765.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. A. Rodd, R. I. Melendez, R. L. Bell, K. A. Kuc, Y. Zhang, J. M. Murphy, and W. J. McBride
Intracranial Self-Administration of Ethanol within the Ventral Tegmental Area of Male Wistar Rats: Evidence for Involvement of Dopamine Neurons
J. Neurosci.,
February 4, 2004;
24(5):
1050 - 1057.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. A. Rodd-Henricks, D. L. McKinzie, T.-K. Li, J. M. Murphy, and W. J. McBride
Cocaine Is Self-Administered into the Shell but Not the Core of the Nucleus Accumbens of Wistar Rats
J. Pharmacol. Exp. Ther.,
December 1, 2002;
303(3):
1216 - 1226.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z.-X. Xi and E. A. Stein
GABAergic MECHANISMS OF OPIATE REINFORCEMENT
Alcohol Alcohol.,
September 1, 2002;
37(5):
485 - 494.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Zangen, S. Ikemoto, J. E. Zadina, and R. A. Wise
Rewarding and Psychomotor Stimulant Effects of Endomorphin-1: Anteroposterior Differences within the Ventral Tegmental Area and Lack of Effect in Nucleus Accumbens
J. Neurosci.,
August 15, 2002;
22(16):
7225 - 7233.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. T. Williams, M. J. Christie, and O. Manzoni
Cellular and Synaptic Adaptations Mediating Opioid Dependence
Physiol Rev,
January 1, 2001;
81(1):
299 - 343.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Martin, S. A. Kim, D. G. Cannon, G. M. Sizemore, D. Bian, F. Porreca, and J. E. Smith
Antagonism of delta 2-Opioid Receptors by Naltrindole-5'-isothiocyanate Attenuates Heroin Self-Administration but Not Antinociception in Rats
J. Pharmacol. Exp. Ther.,
September 1, 2000;
294(3):
975 - 982.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Z.-X. Xi and E. A. Stein
Baclofen Inhibits Heroin Self-Administration Behavior and Mesolimbic Dopamine Release
J. Pharmacol. Exp. Ther.,
September 1, 1999;
290(3):
1369 - 1374.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
O. J. Manzoni and J. T. Williams
Presynaptic Regulation of Glutamate Release in the Ventral Tegmental Area During Morphine Withdrawal
J. Neurosci.,
August 1, 1999;
19(15):
6629 - 6636.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. A. Pohorecky, A. Skiandos, X. Zhang, K. C. Rice, and D. Benjamin
Effect of Chronic Social Stress on delta -Opioid Receptor Function in the Rat
J. Pharmacol. Exp. Ther.,
July 1, 1999;
290(1):
196 - 206.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. M. van Ree, M. A. F. M. Gerrits, and L. J. M. J. Vanderschuren
Opioids, Reward and Addiction: An Encounter of Biology, Psychology, and Medicine
Pharmacol. Rev.,
June 1, 1999;
51(2):
341 - 396.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. S. Negus, M. B. Gatch, N. K. Mello, X. Zhang, and K. Rice
Behavioral Effects of the Delta-Selective Opioid Agonist SNC80 and Related Compounds in Rhesus Monkeys
J. Pharmacol. Exp. Ther.,
July 1, 1998;
286(1):
362 - 375.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Z.-X. Xi, S. A. Fuller, and E. A. Stein
Dopamine Release in the Nucleus Accumbens during Heroin Self-Administration Is Modulated by Kappa Opioid Receptors: An In Vivo Fast-Cyclic Voltammetry Study
J. Pharmacol. Exp. Ther.,
January 1, 1998;
284(1):
151 - 161.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
B. Bontempi and F. R. Sharp
Systemic Morphine-Induced Fos Protein in the Rat Striatum and Nucleus Accumbens Is Regulated by µ Opioid Receptors in the Substantia Nigra and Ventral Tegmental Area
J. Neurosci.,
November 1, 1997;
17(21):
8596 - 8612.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
