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Journal of Neuroscience, Vol 14, 2054-2068, Copyright © 1994 by Society for Neuroscience
Regulation of neurotrophin receptor expression during embryonic and postnatal development
E Escandon, D Soppet, A Rosenthal, JL Mendoza-Ramirez, E Szonyi, LE Burton, CE Henderson, LF Parada and K Nikolics
Department of Neuroscience, Genentech, Inc., South San Francisco, California 94080-4990.
Members of the NGF family of proteins act as neurotrophic agents for
defined populations of peripheral and central neurons during embryonic and
postnatal development. We have studied the presence of receptors for
brain-derived neurotrophic factor (BDNF) and neurotrophin-3 and - 4/5
(NT-3, NT-4/5) by cross-linking radioiodinated neurotrophins to specific
cell surface receptors. We have identified neurotrophin receptors
representing full-length TrkB and TrkC and their truncated forms (lacking a
functional cytoplasmic kinase domain) in neuronal as well as in
non-neuronal tissues. During chicken embryonic and early postnatal brain
development, expression of full-length TrkB and TrkC proteins preceded the
onset of the truncated forms of these receptors. A similar pattern was also
observed in mouse embryonic and early postnatal brain. The relative levels
of neurotrophin receptors in the basal forebrain and in the hippocampus did
not change significantly with age in mice. High levels of receptors for the
three neurotrophins were detected in the nigrostriatal system. Full-length
TrkB and TrkC receptors were found in chicken and rat embryonic ventral
spinal cord, as well as on purified motoneurons. Again, truncated TrkB
appeared significantly later than the full-length form on spinal
motoneurons. In chicken embryonic retina and optic tectum we detected
full-length TrkB and TrkC; however, the optic tectum also expressed large
amounts of the truncated form of TrkB. TrkC but not TrkB was detected in
chicken embryonic skeletal muscle, suggesting that NT-3 may have a novel
function in this tissue. The presence of neurotrophin receptors in a wide
variety of embryonic and postnatal tissues underlines the significant role
of BDNF, NT-3, and NT-4/5 in embryonic and postnatal development. The
regulation of the ratio of full-length versus truncated neurotrophin
receptors may play an important role in the development, maturation, and
maintenance of various neuronal networks.
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|
|
|
|
|
|
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|
|
|
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|
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|
|
|
|
|
|
|
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18(6):
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[Full Text]
[PDF]
|
|
|
|
|
|
|
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17(14):
5281 - 5287.
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|
|
|
|
|
|
|
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17(10):
3623 - 3633.
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[Full Text]
[PDF]
|
|
|
|
|
|
|
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17(8):
2683 - 2690.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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April 1, 1997;
94(7):
3357 - 3362.
[Abstract]
[Full Text]
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|
|
|
|
|
|
|
S. McKay, a Garner, J Caldero, R. Tucker, T Large, and R. Oppenheim
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January 2, 1996;
122(2):
715 - 724.
[Abstract]
[PDF]
|
|
|
|
|
|
|
H Kang, L Z Jia, K Y Suh, L Tang, and E M Schuman
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January 1, 1996;
3(2-3):
188 - 196.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S Biffo, N Offenhauser, B. Carter, and Y. Barde
Selective binding and internalisation by truncated receptors restrict the availability of BDNF during development
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January 8, 1995;
121(8):
2461 - 2470.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R Tuttle and W. Matthew
Neurotrophins affect the pattern of DRG neurite growth in a bioassay that presents a choice of CNS and PNS substrates
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January 5, 1995;
121(5):
1301 - 1309.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. P. Henderson, L. Lin, A. Prasad, C. A. Paul, T. Y. Chang, and R. A. Maue
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June 23, 2000;
275(26):
20179 - 20187.
[Abstract]
[Full Text]
[PDF]
|
|
|
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