QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lin, F. Articles by Stevens, C. F. Search for Related Content PubMed PubMed Citation Articles by Lin, F. Articles by Stevens, C. F.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 14, 2153-2160, Copyright © 1994 by Society for Neuroscience

ARTICLE

Both open and closed NMDA receptor channels desensitize

F Lin and CF Stevens
Howard Hughes Medical Institute at Salk Institute, La Jolla, California 92037.

Desensitization of NMDA receptors was studied at the single-channel level using outside-out patches taken from rat hippocampus CA neurons maintained short term in culture. The amount of desensitization that accumulated as a function of time during the application of NMDA (2.5 microM) was measured by the response to the rapid application of NMDA at a high concentration (100 microM). Records were sorted into two classes: those in which no openings were detected during the application of 2.5 microM NMDA, and those in which some channel openings occurred. Analysis of these data reveals that some desensitization accumulated when no channels opened, but that more desensitization developed when channels opened. The observations indicate that channels can pass from the closed state to the desensitized state, but that desensitization occurs more rapidly from the open state.

This article has been cited by other articles:

				H.-R. Chang and C.-C. Kuo Characterization of the Gating Conformational Changes in the Felbamate Binding Site in NMDA Channels Biophys. J., July 15, 2007; 93(2): 456 - 466. [Abstract] [Full Text] [PDF]

				C.-C. Kuo, B.-J. Lin, H.-R. Chang, and C.-P. Hsieh Use-Dependent Inhibition of the N-Methyl-D-aspartate Currents by Felbamate: a Gating Modifier with Selective Binding to the Desensitized Channels Mol. Pharmacol., February 1, 2004; 65(2): 370 - 380. [Abstract] [Full Text] [PDF]

				N. Lobitz, G. Gisselmann, H. Hatt, and C. H. Wetzel A Single Amino-Acid in the TM1 Domain Is an Important Determinant of the Desensitization Kinetics of Recombinant Human and Guinea Pig {alpha}-Homomeric 5-Hydroxytryptamine Type 3 Receptors Mol. Pharmacol., April 1, 2001; 59(4): 844 - 851. [Abstract] [Full Text]

				A. I. Sobolevsky, S. G. Koshelev, and B. I. Khodorov Probing of NMDA Channels with Fast Blockers J. Neurosci., December 15, 1999; 19(24): 10611 - 10626. [Abstract] [Full Text] [PDF]

				Y. Lu, M. J. Marks, and A. C. Collins Desensitization of Nicotinic Agonist-Induced [3H]gamma -Aminobutyric Acid Release from Mouse Brain Synaptosomes Is Produced by Subactivating Concentrations of Agonists J. Pharmacol. Exp. Ther., December 1, 1999; 291(3): 1127 - 1134. [Abstract] [Full Text]

				A. C. Puche and M. T. Shipley Odor-Induced, Activity-Dependent Transneuronal Gene Induction In Vitro: Mediation by NMDA Receptors J. Neurosci., February 15, 1999; 19(4): 1359 - 1370. [Abstract] [Full Text] [PDF]

				C. Li, R. W. Peoples, and F. F. Weight Mg2+ Inhibition of ATP-Activated Current in Rat Nodose Ganglion Neurons: Evidence That Mg2+ Decreases the Agonist Affinity of the Receptor J Neurophysiol, June 1, 1997; 77(6): 3391 - 3395. [Abstract] [Full Text] [PDF]

				J. A. Dzubay and C. E. Jahr Kinetics of NMDA Channel Opening J. Neurosci., July 1, 1996; 16(13): 4129 - 4134. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help