QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Vos, B. P. Articles by Maciewicz, R. J. Search for Related Content PubMed PubMed Citation Articles by Vos, B. P. Articles by Maciewicz, R. J.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 14, 2708-2723, Copyright © 1994 by Society for Neuroscience

ARTICLE

Behavioral evidence of trigeminal neuropathic pain following chronic constriction injury to the rat's infraorbital nerve

BP Vos, AM Strassman and RJ Maciewicz
Department of Neurology, Massachusetts General Hospital, Charlestown.

Video recordings of free behavior and responses to mechanical facial stimulation were analyzed to assess whether chronic constriction injury (CCI) to the rat's infraorbital nerve (IoN) results in behavioral alterations indicative of neuropathic pain. A unilateral CCI was produced by placing loose chromic gut ligatures around the IoN. After CCI to the IoN, rats exhibited changes in both non-evoked and evoked behavior. Behavioral changes developed in two phases. Early after CCI (postoperative days 1-15), rats showed increased face-grooming activity with face-wash strokes directed to the injured nerve territory, while the responsiveness to stimulation of this area was decreased. Later after CCI (postoperative days 15-130), the prevalence of asymmetric face grooming was reduced but remained significantly increased compared to control rats. The early hyporesponsiveness was abruptly replaced by an extreme hyperresponsiveness: all stimulus intensities applied to the injured nerve territory evoked the "maximal" response (brisk head withdrawal, avoidance behavior plus directed face grooming). This response was never observed in control rats. Concurrently, IoN ligation rats showed a limited increase in the responsiveness to stimulation of the contralateral IoN territory, and around postoperative days 30-40 the responsiveness to stimulation of facial areas outside the IoN territories also increased. The hyperresponsiveness to stimulation of the ligated IoN territory slightly decreased from 60 d postoperative. Throughout the study, IoN ligation rats showed decreased exploratory behavior, displayed more freezing-like behavior, had a slower body weight gain, and a higher defecation rate, compared to control rats. The behavioral alterations observed after CCI to the IoN are indicative of severe sensory disturbances within the territory of the injured nerve: mechanical allodynia develops after a period of relative hypo- /anesthesia during which behavioral signs of recurrent spontaneous, aversive (possibly painful) sensations (paresthesias/dysesthesias) are maximal.

This article has been cited by other articles:

				A. Latremoliere, A. Mauborgne, J. Masson, S. Bourgoin, V. Kayser, M. Hamon, and M. Pohl Differential Implication of Proinflammatory Cytokine Interleukin-6 in the Development of Cephalic versus Extracephalic Neuropathic Pain in Rats J. Neurosci., August 20, 2008; 28(34): 8489 - 8501. [Abstract] [Full Text] [PDF]

				K. Saito, S. Hitomi, I. Suzuki, Y. Masuda, J. Kitagawa, Y. Tsuboi, M. Kondo, B. J. Sessle, and K. Iwata Modulation of Trigeminal Spinal Subnucleus Caudalis Neuronal Activity Following Regeneration of Transected Inferior Alveolar Nerve in Rats J Neurophysiol, May 1, 2008; 99(5): 2251 - 2263. [Abstract] [Full Text] [PDF]

				J.-P. Vit, P. T. Ohara, A. Bhargava, K. Kelley, and L. Jasmin Silencing the Kir4.1 Potassium Channel Subunit in Satellite Glial Cells of the Rat Trigeminal Ganglion Results in Pain-Like Behavior in the Absence of Nerve Injury J. Neurosci., April 16, 2008; 28(16): 4161 - 4171. [Abstract] [Full Text] [PDF]

				J. G. Chichorro, A. R. Zampronio, and G. A. Rae Endothelin ETB Receptor Antagonist Reduces Mechanical Allodynia in Rats with Trigeminal Neuropathic Pain. Experimental Biology and Medicine, June 1, 2006; 231(6): 1136 - 1140. [Abstract] [Full Text] [PDF]

				K. Deseure, W. Koek, H. Adriaensen, and F. C. Colpaert Continuous Administration of the 5-Hydroxytryptamine1A Agonist (3-Chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl) -amino]-methyl}piperidin-1-yl]-methadone (F 13640) Attenuates Allodynia-Like Behavior in a Rat Model of Trigeminal Neuropathic Pain J. Pharmacol. Exp. Ther., August 1, 2003; 306(2): 505 - 514. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help