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Journal of Neuroscience, Vol 14, 2854-2860, Copyright © 1994 by Society for Neuroscience
Distinct populations of sensory neurons mediate the peristaltic reflex elicited by muscle stretch and mucosal stimulation
JR Grider and JG Jin
Department of Physiology, Medical College of Virginia, Richmond 23298.
Recent studies suggest that muscle stretch and mucosal stimulation elicit
intestinal peristalsis by activating distinct populations of sensory
neurons that converge on the same population of enteric motor neurons. The
present study sought to characterize the origin and projections of these
sensory neurons. The reflex was elicited by applying muscle stretch and
mucosal stroking to the central compartment of a three-compartment
flat-sheet preparation of rat colon while ascending contraction and
descending relaxation were measured in the orad and caudad compartments,
respectively. Identical graded responses were elicited by muscle stretch
and mucosal stimulation: atropine (1 microM) and the tachykinin antagonist
spantide (10 microM) inhibited ascending contraction when added to the orad
compartment only, while the vasoactive intestinal peptide antagonist
VIP10-28 (10 microM) and the NO synthase inhibitor NG-nitro-L-arginine (100
microM) inhibited descending relaxation when added to the caudad
compartment only. Addition of capsaicin (1 microM) to the central
compartment for 30 min abolished ascending contraction and descending
relaxation elicited by muscle stretch and mucosal stimulation. Recovery of
response was complete when capsaicin was applied to the mucosa of the colon
in situ and measurements made 1 d after, implying that at this low
concentration capsaicin depleted sensory nerve terminals of their
transmitter content.(ABSTRACT TRUNCATED AT 250 WORDS)
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