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Journal of Neuroscience, Vol 14, 2943-2952, Copyright © 1994 by Society for Neuroscience
Distribution of agrin mRNAs in the chick embryo nervous system
E Ma, R Morgan and EW Godfrey
Department of Cellular Biology and Anatomy, Medical College of Wisconsin, Milwaukee 53226.
Agrin is a synapse-organizing protein likely to mediate nerve-induced
aggregation of acetylcholine receptors and other postsynaptic components at
the neuromuscular junction. We used in situ hybridization and polymerase
chain reaction (PCR) to define the localization of agrin mRNA and its
alternatively spliced forms in the chick embryo nervous system. Agrin cRNA
probes intensely labeled motor neurons, dorsal root ganglia, cerebellar
Purkinje neurons, and retinal ganglion cells. Neuronal layers in optic
tectum and ventricular regions were also labeled. Analysis by PCR showed
that all parts of the nervous system at embryonic day 10 contained three
major forms of agrin mRNA. Our results raise the possibility that agrin
isoforms play a role in synapse formation or other aspects of neuronal
development in the central nervous system.
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