 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 14, 2943-2952, Copyright © 1994 by Society for Neuroscience
Distribution of agrin mRNAs in the chick embryo nervous system
E Ma, R Morgan and EW Godfrey
Department of Cellular Biology and Anatomy, Medical College of Wisconsin, Milwaukee 53226.
Agrin is a synapse-organizing protein likely to mediate nerve-induced
aggregation of acetylcholine receptors and other postsynaptic components at
the neuromuscular junction. We used in situ hybridization and polymerase
chain reaction (PCR) to define the localization of agrin mRNA and its
alternatively spliced forms in the chick embryo nervous system. Agrin cRNA
probes intensely labeled motor neurons, dorsal root ganglia, cerebellar
Purkinje neurons, and retinal ganglion cells. Neuronal layers in optic
tectum and ventricular regions were also labeled. Analysis by PCR showed
that all parts of the nervous system at embryonic day 10 contained three
major forms of agrin mRNA. Our results raise the possibility that agrin
isoforms play a role in synapse formation or other aspects of neuronal
development in the central nervous system.
This article has been cited by other articles:
|
|
|
|
 
J.-F. Yang, G. Cao, S. Koirala, L. V. Reddy, and C.-P. Ko
Schwann Cells Express Active Agrin and Enhance Aggregation of Acetylcholine Receptors on Muscle Fibers
J. Neurosci.,
December 15, 2001;
21(24):
9572 - 9584.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. E. Bandtlow and D. R. Zimmermann
Proteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins
Physiol Rev,
October 1, 2000;
80(4):
1267 - 1290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Halfter, S. Dong, B. Schurer, and G. J. Cole
Collagen XVIII Is a Basement Membrane Heparan Sulfate Proteoglycan
J. Biol. Chem.,
September 25, 1998;
273(39):
25404 - 25412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Gesemann, A. Brancaccio, B. Schumacher, and M. A. Ruegg
Agrin Is a High-affinity Binding Protein of Dystroglycan in Non-muscle Tissue
J. Biol. Chem.,
January 2, 1998;
273(1):
600 - 605.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Meier, D. M. Hauser, M. Chiquet, L. Landmann, M. A. Ruegg, and H. R. Brenner
Neural Agrin Induces Ectopic Postsynaptic Specializations in Innervated Muscle Fibers
J. Neurosci.,
September 1, 1997;
17(17):
6534 - 6544.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Smith, G. R. Fanger, L. T. O'Connor, P. Bridle, and R. A. Maue
Selective Regulation of Agrin mRNA Induction and Alternative Splicing in PC12 Cells by Ras-dependent Actions of Nerve Growth Factor
J. Biol. Chem.,
June 20, 1997;
272(25):
15675 - 15681.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Kirsch and S. Kroger
{blacksquare} REVIEW : Postsynaptic Anchoring of Receptors: A Cellular Approach to Neuronal and Muscular Sensitivity
Neuroscientist,
March 1, 1996;
2(2):
100 - 108.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G Escher, C Bechade, S Levi, and A Triller
Axonal targeting of agrin in cultured rat dorsal horn neurons
J. Cell Sci.,
January 12, 1996;
109(13):
2959 - 2966.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. Tsen, A. Napier, W. Halfter, and G. J. Cole
Identification of a Novel Alternatively Spliced Agrin mRNA That Is Preferentially Expressed in Non-neuronal Cells
J. Biol. Chem.,
July 7, 1995;
270(27):
15934 - 15937.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Tsen, W. Halfter, S. Kröger, and G. J. Cole
Agrin Is a Heparan Sulfate Proteoglycan
J. Biol. Chem.,
February 17, 1995;
270(7):
3392 - 3399.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
