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Journal of Neuroscience, Vol 14, 3426-3436, Copyright © 1994 by Society for Neuroscience
Blue cones and cone bipolar cells share transcriptional specificity as determined by expression of human blue visual pigment-derived transgenes
MI Chiu and J Nathans
Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Sequences 5' of the human blue visual pigment gene have been assayed in
transgenic mice for their ability to direct cell-type-specific expression
of linked beta-galactosidase (lacZ) and placental alkaline phosphatase (P
ALP1) reporters. Constructs containing either 5.4 kilobases (kb) or 0.47 kb
of 5' flanking DNA direct expression exclusively to the retina. Within the
retina, transgene expression is confined to blue cones and cone bipolar
cells, as determined, respectively, by double labeling with anti-cone
pigment antibodies and by morphologic analyses. These results imply that
blue cones and cone bipolar cells have partially overlapping
transcriptional specificities.
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