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Journal of Neuroscience, Vol 14, 3635-3642, Copyright © 1994 by Society for Neuroscience
Serotonin modulates photic responses in the hamster suprachiasmatic nuclei
MA Rea, JD Glass and CS Colwell
Circadian Neurobiology Research Group, Armstrong Laboratory, Brooks AFB, Texas 78235.
The aim of the present study was to examine the effects of serotonin
agonists on three elements of the photic response in the hamster
suprachiasmatic nuclei (SCN). Both serotonin and the selective 5-HT1A
agonist 8-OH-DPAT inhibited field potentials recorded in the SCN in
response to optic nerve stimulation in the hypothalamic slice preparation.
The effects of both drugs were dose related over a concentration range of
1-50 microM, and, in both cases, a maximal inhibition of approximately 60%
was achieved at a concentration of 25- 50 microM. Systemic administration
of 8-OH-DPAT inhibited light- stimulated Fos expression in the SCN. A
regionally selective pattern of inhibition was observed, with decreases
restricted predominately to the ventral and dorsal borders of the SCN.
Finally, systemic administration of 8-OH-DPAT was found to dose-dependently
attenuate light-induced phase shifts of the free-running activity rhythm.
The effects of 8-OH- DPAT on light-induced phase advances were dose
dependent. Injection of 8-OH-DPAT at a dose of 0.5 mg/kg caused 57%
inhibition of light-induced phase advances, while a dose of 5 mg/kg
inhibited the phase advance by 82%. Injection of 0.05 mg/kg 8-OH-DPAT did
not significantly inhibit light-induced phase advances. Injection of 5
mg/kg 8-OH-DPAT alone did not significantly alter the phase of the activity
rhythm. Similarly, injection of 5 mg/kg 8-OH-DPAT 30 min prior to light
stimulation at CT14 completely inhibited light-induced phase delays, while
this dose of the drug did not alter the phase of the activity rhythm when
administered alone.(ABSTRACT TRUNCATED AT 250 WORDS)
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