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Journal of Neuroscience, Vol 14, 3725-3735, Copyright © 1994 by Society for Neuroscience
Distribution of fos-like immunoreactivity in the medullary and upper cervical dorsal horn produced by stimulation of dural blood vessels in the rat
AM Strassman, Y Mineta and BP Vos
Department of Neurology, Massachusetts General Hospital, Charlestown.
Neurophysiological studies have generally failed to find evidence of a
specific ascending pathway for visceral nociception. However, pain that
arises from deep or visceral tissues typically differs from cutaneous pain,
particularly in its diffuse, poorly localized quality. In this study, the
c-fos mapping technique was used in order to investigate possible
differences in the distribution of central neurons activated by afferent
pathways from cutaneous and deep tissues that may be related to the
differing quality of the sensations they evoke. The distribution of neurons
in the upper cervical and medullary dorsal horn that displayed fos-like
immunoreactivity (fos-LI) was examined following mechanical stimulation of
dural blood vessels (transverse and superior sagittal sinuses), and was
compared to that found following mechanical, thermal, and chemical
stimulation of facial sites. Dural stimulation was carried out Brevital
anesthesia in rats that had received a chronic surgical exposure of the
transverse and superior sagittal sinuses 2 d earlier. Localized mechanical
stimulation of the dural surface of the transverse sinus produced a
predominantly ipsilateral increase in the number of fos-LI neurons in the
medullary and upper cervical dorsal horn (primarily laminae I and V), and
in the transition region between the trigeminal nucleus caudalis and
interpolaris. Stimulation of the superior sagittal sinus produced increases
in fos-LI labeling that were generally smaller than those produced by
transverse sinus stimulation. The distribution of fos-LI labeling in the
dorsal horn induced by dural stimulation differed from that induced by
facial stimulation in two ways. (1) Dural stimulation produced a more
diffuse distribution of fos-LI than facial stimulation in the dorsal horn.
Whereas facial stimulation produced a dense, localized zone of fos-LI
labeling in the dorsal horn, dural stimulation produced fos-LI labeling
that extended from the midlevel of caudalis to C2/C3, and also extended
across a large portion of the ventrolateral-to- dorsomedial axis of the
dorsal horn. This distribution roughly corresponds to the representation of
most of the dorsal half of the head and face. (2) Dural stimulation
produced a more restricted laminar distribution of fos-LI labeling than
facial stimulation, in that the dural-induced labeling in the superficial
dorsal horn was primarily restricted to lamina I, whereas facial
stimulation typically induced substantial labeling in both lamina I and the
outer part of lamina II. These differences in the central organization of
the afferent pathways from dural and facial sites may contribute to the
differences in the quality of sensations evoked by these pathways.
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