 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 14, 3751-3765, Copyright © 1994 by Society for Neuroscience
Intraventricular administration of BDNF increases neuropeptide expression in newborn rat brain
H Nawa, MA Pelleymounter and J Carnahan
Beckman Neuroscience Center, Cold Spring Harbor Laboratory, New York, NY 11724.
Brain-derived neurotrophic factor (BDNF) specifically enhances and
maintains the expression of neuropeptide Y (NPY) and somatostatin (SOM) in
cultured neocortical neurons (Nawa et al., 1993). In this article, we
examined its effects in vivo on neuropeptide expression in various brain
regions by injecting BDNF into the cerebroventricle of newborn rats.
Repeated administration (2x) of BDNF increased contents of NPY- like
immunoreactivity (NPY-LI) and substance P (SP)-LI most markedly in the
anterior neocortex by 11- and 24-fold, respectively, in comparison to
values in the animals receiving control injection. A smaller but
significant increase was also observed in immunoreactivity for somatostatin
(SOM), enkephalin (ENK), and cholecystokinin (CCK). mRNA for NPY, SP, and
SOM was similarly upregulated in the anterior neocortex, suggesting that
BDNF enhances peptide synthesis rather than inhibiting peptide release or
degradation. Among the brain regions examined, however, peptidergic
responses to BDNF were different with respect to their spatial distribution
and time course. Induction of SP- LI, NPY-LI, and SOM-LI around the
injection site was most pronounced in cortical layers II/III, layers IV-VI,
and layer VI, respectively. Peptidergic immunoreactivity was also enhanced
in other brain regions ipsilateral to the injection site, for example,
NPY-LI in the hippocampus, thalamic nuclei, and striatum, and SOM-LI in the
striatum. A single injection of BDNF elevated SP-LI to a plateau level
within 12 hr while NPY-LI and SOM-LI reached maximum levels at 48 hr, and
then all returned to control levels at 68 hr. In contrast, the same dose of
NGF had no influences on the neuropeptide levels at 48 hr. These
observations suggest that BDNF regulates the development of neuropeptide
expression in the CNS in a plastic manner.
This article has been cited by other articles:
|
|
|
|
 
B. Arango-Gonzalez, A. Cellerino, and K. Kohler
Exogenous Brain-Derived Neurotrophic Factor (BDNF) Reverts Phenotypic Changes in the Retinas of Transgenic Mice Lacking the bdnf Gene
Invest. Ophthalmol. Vis. Sci.,
March 1, 2009;
50(3):
1416 - 1422.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. M. Morris, T. Hashimoto, and D. A. Lewis
Alterations in Somatostatin mRNA Expression in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia or Schizoaffective Disorder
Cereb Cortex,
July 1, 2008;
18(7):
1575 - 1587.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Thakker-Varia, J. J. Krol, J. Nettleton, P. M. Bilimoria, D. A. Bangasser, T. J. Shors, I. B. Black, and J. Alder
The Neuropeptide VGF Produces Antidepressant-Like Behavioral Effects and Enhances Proliferation in the Hippocampus
J. Neurosci.,
November 7, 2007;
27(45):
12156 - 12167.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. C. Pandey, H. Zhang, A. Roy, and K. Misra
Central and medial amygdaloid brain-derived neurotrophic factor signaling plays a critical role in alcohol-drinking and anxiety-like behaviors.
J. Neurosci.,
August 9, 2006;
26(32):
8320 - 8331.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Givalois, G. Naert, L. Tapia-Arancibia, and S. Arancibia
Involvement of brain-derived neurotrophic factor in the regulation of hypothalamic somatostatin in vivo.
J. Endocrinol.,
March 1, 2006;
188(3):
425 - 433.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. G. Smith, L. Betancourt, and Y. Sun
Molecular Endocrinology and Physiology of the Aging Central Nervous System
Endocr. Rev.,
April 1, 2005;
26(2):
203 - 250.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. C. Danzer and J. O. McNamara
Localization of Brain-Derived Neurotrophic Factor to Distinct Terminals of Mossy Fiber Axons Implies Regulation of Both Excitation and Feedforward Inhibition of CA3 Pyramidal Cells
J. Neurosci.,
December 15, 2004;
24(50):
11346 - 11355.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Jin, H. Hu, P. H. Mathers, and A. Agmon
Brain-Derived Neurotrophic Factor Mediates Activity-Dependent Dendritic Growth in Nonpyramidal Neocortical Interneurons in Developing Organotypic Cultures
J. Neurosci.,
July 2, 2003;
23(13):
5662 - 5673.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Cotrufo, A. Viegi, N. Berardi, Y. Bozzi, L. Mascia, and L. Maffei
Effects of Neurotrophins on Synaptic Protein Expression in the Visual Cortex of Dark-Reared Rats
J. Neurosci.,
May 1, 2003;
23(9):
3566 - 3571.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Rios, G. Fan, C. Fekete, J. Kelly, B. Bates, R. Kuehn, R. M. Lechan, and R. Jaenisch
Conditional Deletion Of Brain-Derived Neurotrophic Factor in the Postnatal Brain Leads to Obesity and Hyperactivity
Mol. Endocrinol.,
October 1, 2001;
15(10):
1748 - 1757.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. W. Tao and M.-m. Poo
Retrograde signaling at central synapses
PNAS,
September 25, 2001;
98(20):
11009 - 11015.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Bolton, A. J. Pittman, and D. C. Lo
Brain-Derived Neurotrophic Factor Differentially Regulates Excitatory and Inhibitory Synaptic Transmission in Hippocampal Cultures
J. Neurosci.,
May 1, 2000;
20(9):
3221 - 3232.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Nakamura, S.-i. Sakakibara, T. Miyata, M. Ogawa, T. Shimazaki, S. Weiss, R. Kageyama, and H. Okano
The bHLH Gene Hes1 as a Repressor of the Neuronal Commitment of CNS Stem Cells
J. Neurosci.,
January 1, 2000;
20(1):
283 - 293.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Braun, M. Lommatzsch, A. Mannsfeldt, U. Neuhaus-Steinmetz, A. Fischer, N. Schnoy, G. R. Lewin, and H. Renz
Cellular Sources of Enhanced Brain-Derived Neurotrophic Factor Production in a Mouse Model of Allergic Inflammation
Am. J. Respir. Cell Mol. Biol.,
October 1, 1999;
21(4):
537 - 546.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
F. Rage, B. Riteau, G. Alonso, and L. Tapia-Arancibia
Brain-Derived Neurotrophic Factor and Neurotrophin-3 Enhance Somatostatin Gene Expression through a Likely Direct Effect on Hypothalamic Somatostatin Neurons
Endocrinology,
February 1, 1999;
140(2):
909 - 916.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Frerking, R. C. Malenka, and R. A. Nicoll
Brain-Derived Neurotrophic Factor (BDNF) Modulates Inhibitory, But Not Excitatory, Transmission in the CA1 Region of the Hippocampus
J Neurophysiol,
December 1, 1998;
80(6):
3383 - 3386.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Cellerino, G. Pinzon-Duarte, P. Carroll, and K. Kohler
Brain-Derived Neurotrophic Factor Modulates the Development of the Dopaminergic Network in the Rodent Retina
J. Neurosci.,
May 1, 1998;
18(9):
3351 - 3362.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Fawcett, S. X. Bamji, C. G. Causing, R. Aloyz, A. R. Ase, T. A. Reader, J. H. McLean, and F. D. Miller
Functional Evidence that BDNF Is an Anterograde Neuronal Trophic Factor in the CNS
J. Neurosci.,
April 15, 1998;
18(8):
2808 - 2821.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. M. FITZSIMONDS and M.-M. POO
Retrograde Signaling in the Development and Modification of Synapses
Physiol Rev,
January 1, 1998;
78(1):
143 - 170.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Alcantara, J. Frisen, J. A. del Rio, E. Soriano, M. Barbacid, and I. Silos-Santiago
TrkB Signaling Is Required for Postnatal Survival of CNS Neurons and Protects Hippocampal and Motor Neurons from Axotomy-Induced Cell Death
J. Neurosci.,
May 15, 1997;
17(10):
3623 - 3633.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. A. Vaidya, G. J. Marek, G. K. Aghajanian, and R. S. Duman
5-HT2A Receptor-Mediated Regulation of Brain-Derived Neurotrophic Factor mRNA in the Hippocampus and the Neocortex
J. Neurosci.,
April 15, 1997;
17(8):
2785 - 2795.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. S. Naeve, M. Ramakrishnan, R. Kramer, D. Hevroni, Y. Citri, and L. E. Theill
Neuritin: A gene induced by neural activity and neurotrophins that promotes neuritogenesis
PNAS,
March 18, 1997;
94(6):
2648 - 2653.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Thoenen
Neurotrophins and Neuronal Plasticity
Science,
October 27, 1995;
270(5236):
593 - 598.
[Abstract]
[PDF]
|
|
|
|
|
|
|
B Berninger, S Marty, F Zafra, M da Penha Berzaghi, H Thoenen, and D Lindholm
GABAergic stimulation switches from enhancing to repressing BDNF expression in rat hippocampal neurons during maturation in vitro
Development,
January 8, 1995;
121(8):
2327 - 2335.
[Abstract]
[PDF]
|
|
|
|
|
