QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Moser, E. I. Articles by Andersen, P. Search for Related Content PubMed PubMed Citation Articles by Moser, E. I. Articles by Andersen, P.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 14, 4458-4466, Copyright © 1994 by Society for Neuroscience

ARTICLE

Conserved spatial learning in cooled rats in spite of slowing of dentate field potentials

EI Moser and P Andersen
Department of Neurophysiology, University of Oslo, Norway.

Behaviorally induced brain temperature changes have significant effects on field potentials recorded in the hippocampal formation. All components of the field potential are slowed during cooling. Field excitatory postsynaptic potentials (f-EPSPs) are often reduced, while the population spike is increased in this state. To investigate whether such synaptic alterations affect hippocampus-dependent learning, we have compared the effects of reduced brain temperature on dentate field potentials and spatial learning in a Morris water maze. Rats were implanted with thermistors in the brain. A subset of the rats received electrodes for field potential recording in the perforant path-granule cell synapses of the dentate gyrus. After recovery, the rats were cooled by swimming in a pool of water. This invariably led to a brain temperature reduction of several degrees centigrade and a delay of the extracellular response. In addition, the field potential changed as described above. The effect of these changes on spatial learning in a second pool, the water maze, was determined by first cooling and then reheating each rat to a given level of brain temperature prior to each spatial training session. In spite of marked changes in dentate field potentials, all rats trained at brain temperatures above 30 degrees C learned to find the submerged platform similarly well. The speed of acquisition and the final precision of search behavior were also similar in these rats. Only rats that had been cooled below 30 degrees C failed to locate the hidden target. These animals also showed clear evidence of motor impairment.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				K. Shibasaki, M. Suzuki, A. Mizuno, and M. Tominaga Effects of Body Temperature on Neural Activity in the Hippocampus: Regulation of Resting Membrane Potentials by Transient Receptor Potential Vanilloid 4 J. Neurosci., February 14, 2007; 27(7): 1566 - 1575. [Abstract] [Full Text] [PDF]

				A. E. Talpalar and Y. Grossman Enhanced Excitability Compensates for High-Pressure-Induced Depression of Cortical Inputs to the Hippocampus J Neurophysiol, December 1, 2004; 92(6): 3309 - 3319. [Abstract] [Full Text] [PDF]

				K. Ae. Karlsson and M. S. Blumberg Temperature-Induced Reciprocal Activation of Hippocampal Field Activity J Neurophysiol, January 1, 2004; 91(1): 583 - 588. [Abstract] [Full Text]

				H Eichenbaum Learning from LTP: a comment on recent attempts to identify cellular and molecular mechanisms of memory. Learn. Mem., January 1, 1996; 3(2-3): 61 - 73. [Abstract] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help