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Journal of Neuroscience, Vol 14, 4588-4599, Copyright © 1994 by Society for Neuroscience
Localization of Kv1.1 and Kv1.2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brain
H Wang, DD Kunkel, PA Schwartzkroin and BL Tempel
Geriatric Research Education and Clinical Center, VA Medical Center, Seattle, Washington 98108.
Multiple voltage-gated potassium (K) channel gene products are likely to be
involved in regulating neuronal excitability of any single neuron in the
mammalian brain. Here we show that two closely related voltage- gated K
channel proteins, mKv1.1 and mKv1.2, are present in multiple subcellular
locations including cell somata, juxta-paranodal regions of myelinated
axons, synaptic terminals, unmyelinated axons, specialized junctions among
axons, and proximal dendrites. Staining patterns of the two channel
polypeptides overlap in some areas of the brain, yet each has a unique
pattern of expression. For example, in the hippocampus, both mKv1.1 and
mKv1.2 proteins are present in axons, often near or at synaptic terminals
in the middle molecular layer of the dentate gyrus, while only mKv1.1 is
detected in axons and synaptic terminals in the hilar/CA3 region. In the
cerebellum, both channel proteins are localized to axon terminals and
specialized junctions among axons in the plexus region of basket cells.
Strong differential staining is observed in the olfactory bulb, where
mKv1.2 is localized to cell somata and axons, as well as to proximal
dendrites of the mitral cells. This overlapping yet differential pattern of
expression and specific subcellular localization may contribute to the
unique profile of excitability displayed by a particular neuron.
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Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to Eag and cyclic nucleotide-gated channels
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K. J. Rhodes, B. W. Strassle, M. M. Monaghan, Z. Bekele-Arcuri, M. F. Matos, and J. S. Trimmer
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