 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 14, 4748-4755, Copyright © 1994 by Society for Neuroscience
Sex differences in aging of the human frontal and temporal lobes
PE Cowell, BI Turetsky, RC Gur, RI Grossman, DL Shtasel and RE Gur
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104.
This study investigated effects of age and sex on regional brain structure
in humans, focusing on the frontal and temporal lobes. Hemispheric volumes
were obtained from magnetic resonance images (MRIs) of 96 young (53 men, 43
women; aged 18-40 years) and 34 older (17 men, 17 women; aged 41-80)
healthy volunteers. Images (5 mm axial spin-echo, repetition time of 3000
msec and echo times of 30 and 80 msec) were resliced along the anterior
commissure-posterior commissure (AC-PC) axis to standardize for difference
in head tilt, and imported into a computer program where borders of the
frontal and temporal lobes were delineated. The program calculated regional
brain volumes based on slice data from which CSF was segmented out. An age
x sex x hemisphere x region interaction indicated that age-related
reductions in brain volume were sexually dimorphic, lateralized, and region
specific. Greater decrements in brain volume occurred with age in the
frontal lobe than in the temporal lobe. Age-related reductions in both
regions were greater in men than in women, demonstrating that sexual
dimorphisms in human neuroanatomy are not fixed, but continue to change
throughout adulthood. The possibility that gonadal hormones play a role in
the promotion and/or prevention of neural atrophy with aging is discussed.
This article has been cited by other articles:
|
|
|
|
 
X. Guo, I. Skoog, E. Idrizbegovic, L. Pantoni, M. Simoni, and U. Rosenhall
Hearing loss and cortical atrophy in a population-based study on non-demented women
Age Ageing,
May 1, 2008;
37(3):
333 - 336.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. E. Rettmann, M. A. Kraut, J. L. Prince, and S. M. Resnick
Cross-sectional and Longitudinal Analyses of Anatomical Sulcal Changes Associated with Aging
Cereb Cortex,
November 1, 2006;
16(11):
1584 - 1594.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. F. Witelson, H. Beresh, and D. L. Kigar
Intelligence and brain size in 100 postmortem brains: sex, lateralization and age factors
Brain,
February 1, 2006;
129(2):
386 - 398.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. van den Boom, M. Bornebroek, F. Behloul, A. A. van den Berg-Huysmans, J. Haan, and M. A. van Buchem
Microbleeds in hereditary cerebral hemorrhage with amyloidosis- Dutch type
Neurology,
April 12, 2005;
64(7):
1288 - 1289.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Y. Shan, J. Z. Liu, V. Sahgal, B. Wang, and G. H. Yue
Selective Atrophy of Left Hemisphere and Frontal Lobe of the Brain in Old Men
J. Gerontol. A Biol. Sci. Med. Sci.,
February 1, 2005;
60(2):
165 - 174.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. I. Scahill, C. Frost, R. Jenkins, J. L. Whitwell, M. N. Rossor, and N. C. Fox
A Longitudinal Study of Brain Volume Changes in Normal Aging Using Serial Registered Magnetic Resonance Imaging
Arch Neurol,
July 1, 2003;
60(7):
989 - 994.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. D. Tapp, C. T. Siwak, J. Estrada, D. Holowachuk, and N. W. Milgram
Effects of Age on Measures of Complex Working Memory Span in the Beagle Dog (Canis familiaris) Using Two Versions of a Spatial List Learning Paradigm
Learn. Mem.,
March 1, 2003;
10(2):
148 - 160.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. M. van der Flier, D.M. J. van den Heuvel, A.W. E. Weverling-Rijnsburger, A. Spilt, E.L.E. M. Bollen, R.G. J. Westendorp, H.A. M. Middelkoop, and M. A. van Buchem
Cognitive decline in AD and mild cognitive impairment is associated with global brain damage
Neurology,
September 24, 2002;
59(6):
874 - 879.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Ge, R. I. Grossman, J. S. Babb, M. L. Rabin, L. J. Mannon, and D. L. Kolson
Age-Related Total Gray Matter and White Matter Changes in Normal Adult Brain. Part I: Volumetric MR Imaging Analysis
AJNR Am. J. Neuroradiol.,
September 1, 2002;
23(8):
1327 - 1333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. C. Gur, F. Gunning-Dixon, W. B. Bilker, and R. E. Gur
Sex Differences in Temporo-limbic and Frontal Brain Volumes of Healthy Adults
Cereb Cortex,
September 1, 2002;
12(9):
998 - 1003.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. H. Miller, F. Barkhof, J. A. Frank, G. J. M. Parker, and A. J. Thompson
Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance
Brain,
August 1, 2002;
125(8):
1676 - 1695.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. C. Gur and R. E. Gur
Neuroimaging Applications in Elderly Patients
Am J Geriatr Psychiatry,
February 1, 2002;
10(1):
5 - 11.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. C. Gur, F. M. Gunning-Dixon, B. I. Turetsky, W. B. Bilker, and R. E. Gur
Brain Region and Sex Differences in Age Association With Brain Volume: A Quantitative MRI Study of Healthy Young Adults
Am J Geriatr Psychiatry,
February 1, 2002;
10(1):
72 - 80.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C.W. Brooks, N. Roberts, G. J. Kemp, M. A. Gosney, M. Lye, and G. H. Whitehouse
A Proton Magnetic Resonance Spectroscopy Study of Age-related Changes in Frontal Lobe Metabolite Concentrations
Cereb Cortex,
July 1, 2001;
11(7):
598 - 605.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. De Bellis, M. S. Keshavan, S. R. Beers, J. Hall, K. Frustaci, A. Masalehdan, J. Noll, and A. M. Boring
Sex Differences in Brain Maturation during Childhood and Adolescence
Cereb Cortex,
June 1, 2001;
11(6):
552 - 557.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Matsuzawa, M. Matsui, T. Konishi, K. Noguchi, R. C. Gur, W. Bilker, and T. Miyawaki
Age-related Volumetric Changes of Brain Gray and White Matter in Healthy Infants and Children
Cereb Cortex,
April 1, 2001;
11(4):
335 - 342.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Kaasinen, K. Någren, J. Hietala, L. Farde, and J. O. Rinne
Sex Differences in Extrastriatal Dopamine D2-Like Receptors in the Human Brain
Am J Psychiatry,
February 1, 2001;
158(2):
308 - 311.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. C. Pruessner, D. L. Collins, M. Pruessner, and A. C. Evans
Age and Gender Predict Volume Decline in the Anterior and Posterior Hippocampus in Early Adulthood
J. Neurosci.,
January 1, 2001;
21(1):
194 - 200.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Fannon, X. Chitnis, V. Doku, L. Tennakoon, S. Ó’Ceallaigh, W. Soni, A. Sumich, J. Lowe, M. Santamaria, and T. Sharma
Features of Structural Brain Abnormality Detected in First-Episode Psychosis
Am J Psychiatry,
November 1, 2000;
157(11):
1829 - 1834.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
D. FANNON, L. TENNAKOON, S. O'CEALLAIGH, V. DOKU, W. SONI, X. CHITNIS, J. LOWE, A. SUMICH, and T. SHARMA
Third ventricle enlargement and developmental delay in first-episode psychosis: preliminary findings
The British Journal of Psychiatry,
October 1, 2000;
177(4):
354 - 359.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Janowsky, B. Chavez, and E. Orwoll
Sex Steroids Modify Working Memory
J. Cogn. Neurosci.,
May 1, 2000;
12(3):
407 - 414.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. M. Resnick, A. F. Goldszal, C. Davatzikos, S. Golski, M. A. Kraut, E. J. Metter, R. N. Bryan, and A. B. Zonderman
One-year Age Changes in MRI Brain Volumes in Older Adults
Cereb Cortex,
May 1, 2000;
10(5):
464 - 472.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Kubis, B. A. Faucheux, G. Ransmayr, P. Damier, C. Duyckaerts, D. Henin, B. Forette, Y. Le Charpentier, J.-J. Hauw, Y. Agid, et al.
Preservation of midbrain catecholaminergic neurons in very old human subjects
Brain,
February 1, 2000;
123(2):
366 - 373.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Xu, S. Kobayashi, S. Yamaguchi, K.-i. Iijima, K. Okada, and K. Yamashita
Gender Effects on Age-Related Changes in Brain Structure
AJNR Am. J. Neuroradiol.,
January 1, 2000;
21(1):
112 - 118.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Jonides, C. Marshuetz, E. E. Smith, P. A. Reuter-Lorenz, R. A. Koeppe, and A. Hartley
Age Differences in Behavior and PET Activation Reveal Differences in Interference Resolution in Verbal Working Memory
J. Cogn. Neurosci.,
January 1, 2000;
12(1):
188 - 196.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Narayan, J. D. Bremner, and A. Kumar
Neuroanatomic Substrates of Late-Life Mental Disorders
J Geriatr Psychiatry Neurol,
October 1, 1999;
12(3):
95 - 106.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. C. Gur, B. I. Turetsky, M. Matsui, M. Yan, W. Bilker, P. Hughett, and R. E. Gur
Sex Differences in Brain Gray and White Matter in Healthy Young Adults: Correlations with Cognitive Performance
J. Neurosci.,
May 15, 1999;
19(10):
4065 - 4072.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Yousem, J. A. Maldjian, T. Hummel, D. C. Alsop, R. J. Geckle, M. A. Kraut, and R. L. Doty
The Effect of Age on Odor-Stimulated Functional MR Imaging
AJNR Am. J. Neuroradiol.,
April 1, 1999;
20(4):
600 - 608.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
I. Agartz, R. Momenan, R. R. Rawlings, M. J. Kerich, and D. W. Hommer
Hippocampal Volume in Patients With Alcohol Dependence
Arch Gen Psychiatry,
April 1, 1999;
56(4):
356 - 363.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. A. Magnotta, N. C. Andreasen, S. K. Schultz, G. Harris, T. Cizadlo, D. Heckel, P. Nopoulos, and M. Flaum
Quantitative In Vivo Measurement of Gyrification in the Human Brain: Changes Associated with Aging
Cereb Cortex,
March 1, 1999;
9(2):
151 - 160.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. H. Salat, J. A. Kaye, and J. S. Janowsky
Prefrontal Gray and White Matter Volumes in Healthy Aging and Alzheimer Disease
Arch Neurol,
March 1, 1999;
56(3):
338 - 344.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Kumar, Z. Jin, W. Bilker, J. Udupa, and G. Gottlieb
Late-onset minor and major depression: early evidence for common neuroanatomical substrates detected by using MRI
PNAS,
June 23, 1998;
95(13):
7654 - 7658.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. E. Coffey, J. F. Lucke, J. A. Saxton, G. Ratcliff, L. J. Unitas, B. Billig, and R. N. Bryan
Sex Differences in Brain Aging: A Quantitative Magnetic Resonance Imaging Study
Arch Neurol,
February 1, 1998;
55(2):
169 - 179.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. E. Gur, P. Cowell, B. I. Turetsky, F. Gallacher, T. Cannon, W. Bilker, and R. C. Gur
A Follow-up Magnetic Resonance Imaging Study of Schizophrenia: Relationship of Neuroanatomical Changes to Clinical and Neurobehavioral Measures
Arch Gen Psychiatry,
February 1, 1998;
55(2):
145 - 152.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Nopoulos, M. Flaum, and N. C. Andreasen
Sex Differences in Brain Morphology in Schizophrenia
Am J Psychiatry,
December 1, 1997;
154(12):
1648 - 1654.
[Abstract]
[Full Text]
|
|
|
|
