 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 14, 4871-4881, Copyright © 1994 by Society for Neuroscience
Post-receptor mechanisms underlying striatal long-term depression
P Calabresi, A Pisani, NB Mercuri and G Bernardi
Clinica Neurologica, Dip. Sanita, Universita di Tor Vergata, Rome, Italy.
Extracellular and intracellular recordings were obtained from striatal
neurons in a brain slice preparation in order to characterize the post-
receptor mechanisms underlying striatal posttetanic long-term depression
(LTD). Striatal LTD was blocked in neurons intracellularly recorded either
with 1,2-bis (o-aminophenoxy)-ethane-N,N,N',N'- tetraacetic acid (BAPTA) or
with EGTA, calcium (Ca2+) chelators. Intracellular injection of QX-314, a
lidocaine derivative that has been shown to block voltage-dependent sodium
channels, abolished action potential discharge and blocked striatal LTD.
However, under this condition, striatal LTD was restored when, immediately
before the delivery of the tetanus, the cell was depolarized at a membrane
potential ranging between -30 mV and -20 mV by injecting continuous
positive current. Nifedipine (10 microM), a blocker of voltage- dependent
L-type Ca2+ channels, blocked striatal LTD. Nifedipine by itself altered
neither cortically evoked EPSPs nor input resistance and firing properties
of most of the recorded cells. Striatal LTD was also reduced or blocked by
incubation of the slices in the presence of the following inhibitors of
Ca(2+)-dependent protein kinases: staurosporine (10-50 nM),
1-(5-isoquinolinesulfonyl)-2- methylpiperazine (H-7; 10-50 microM), and
calphostin C (1 microM). Our findings suggest that generation of striatal
LTD requires a Ca2+ influx through voltage- dependent nifedipine-sensitive
Ca2+ channels and a sufficient intracellular free Ca2+ concentration.
Furthermore, this form of synaptic plasticity seems to involve the
activation of Ca(2+)-dependent protein kinases. Different drugs, acting at
receptor and/or post- receptor level, may affect this form of synaptic
plasticity and might alter the formation of motor memory.
This article has been cited by other articles:
|
|
|
|
 
M. Kano, T. Ohno-Shosaku, Y. Hashimotodani, M. Uchigashima, and M. Watanabe
Endocannabinoid-Mediated Control of Synaptic Transmission
Physiol Rev,
January 1, 2009;
89(1):
309 - 380.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Ferraguti, L. Crepaldi, and F. Nicoletti
Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives
Pharmacol. Rev.,
December 1, 2008;
60(4):
536 - 581.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Pawlak and J. N. D. Kerr
Dopamine Receptor Activation Is Required for Corticostriatal Spike-Timing-Dependent Plasticity
J. Neurosci.,
March 5, 2008;
28(10):
2435 - 2446.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. T. Moyer, J. A. Wolf, and L. H. Finkel
Effects of Dopaminergic Modulation on the Integrative Properties of the Ventral Striatal Medium Spiny Neuron
J Neurophysiol,
December 1, 2007;
98(6):
3731 - 3748.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. G. Carter, G. J. Soler-Llavina, and B. L. Sabatini
Timing and Location of Synaptic Inputs Determine Modes of Subthreshold Integration in Striatal Medium Spiny Neurons
J. Neurosci.,
August 15, 2007;
27(33):
8967 - 8977.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. K. Ade and D. M. Lovinger
Anandamide Regulates Postnatal Development of Long-Term Synaptic Plasticity in the Rat Dorsolateral Striatum
J. Neurosci.,
February 28, 2007;
27(9):
2403 - 2409.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. H. Yin and D. M. Lovinger
Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling
PNAS,
May 23, 2006;
103(21):
8251 - 8256.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Olson, T. Tkatch, S. Hernandez-Lopez, S. Ulrich, E. Ilijic, E. Mugnaini, H. Zhang, I. Bezprozvanny, and D. J. Surmeier
G-Protein-Coupled Receptor Modulation of Striatal CaV1.3 L-Type Ca2+ Channels Is Dependent on a Shank-Binding Domain
J. Neurosci.,
February 2, 2005;
25(5):
1050 - 1062.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Ronesi and D. M. Lovinger
Induction of striatal long-term synaptic depression by moderate frequency activation of cortical afferents in rat
J. Physiol.,
January 1, 2005;
562(1):
245 - 256.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Bonsi, C. De Persis, P. Calabresi, G. Bernardi, and A. Pisani
Coordinate high-frequency pattern of stimulation and calcium levels control the induction of LTP in striatal cholinergic interneurons
Learn. Mem.,
November 1, 2004;
11(6):
755 - 760.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Picconi, D. Centonze, S. Rossi, G. Bernardi, and P. Calabresi
Therapeutic doses of L-dopa reverse hypersensitivity of corticostriatal D2-dopamine receptors and glutamatergic overactivity in experimental parkinsonism
Brain,
July 1, 2004;
127(7):
1661 - 1669.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Day, P. A. Olson, J. Platzer, J. Striessnig, and D. J. Surmeier
Stimulation of 5-HT2 Receptors in Prefrontal Pyramidal Neurons Inhibits Cav1.2 L-Type Ca2+ Currents Via a PLCbeta /IP3/Calcineurin Signaling Cascade
J Neurophysiol,
May 1, 2002;
87(5):
2490 - 2504.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. G. Partridge, S. Apparsundaram, G. A. Gerhardt, J. Ronesi, and D. M. Lovinger
Nicotinic Acetylcholine Receptors Interact with Dopamine in Induction of Striatal Long-Term Depression
J. Neurosci.,
April 1, 2002;
22(7):
2541 - 2549.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. N. D. Kerr and D. Plenz
Dendritic Calcium Encodes Striatal Neuron Output during Up-States
J. Neurosci.,
March 1, 2002;
22(5):
1499 - 1512.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K.-W. Sung, S. Choi, and D. M. Lovinger
Activation of Group I mGluRs Is Necessary for Induction of Long-Term Depression at Striatal Synapses
J Neurophysiol,
November 1, 2001;
86(5):
2405 - 2412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Calabresi, P. Gubellini, B. Picconi, D. Centonze, A. Pisani, P. Bonsi, P. Greengard, R. A. Hipskind, E. Borrelli, and G. Bernardi
Inhibition of Mitochondrial Complex II Induces a Long-Term Potentiation of NMDA-Mediated Synaptic Excitation in the Striatum Requiring Endogenous Dopamine
J. Neurosci.,
July 15, 2001;
21(14):
5110 - 5120.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.N.D. Kerr and J. R. Wickens
Dopamine D-1/D-5 Receptor Activation Is Required for Long-Term Potentiation in the Rat Neostriatum In Vitro
J Neurophysiol,
January 1, 2001;
85(1):
117 - 124.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K.-C. Tang and D. M. Lovinger
Role of Pertussis Toxin-Sensitive G-Proteins in Synaptic Transmission and Plasticity at Corticostriatal Synapses
J Neurophysiol,
January 1, 2000;
83(1):
60 - 69.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Centonze, P. Gubellini, B. Picconi, P. Calabresi, P. Giacomini, and G. Bernardi
Unilateral Dopamine Denervation Blocks Corticostriatal LTP
J Neurophysiol,
December 1, 1999;
82(6):
3575 - 3579.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Brown, D. Bullock, and S. Grossberg
How the Basal Ganglia Use Parallel Excitatory and Inhibitory Learning Pathways to Selectively Respond to Unexpected Rewarding Cues
J. Neurosci.,
December 1, 1999;
19(23):
10502 - 10511.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Calabresi, D. Centonze, P. Gubellini, G. A. Marfia, and G. Bernardi
Glutamate-Triggered Events Inducing Corticostriatal Long-Term Depression
J. Neurosci.,
July 15, 1999;
19(14):
6102 - 6110.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Calabresi, P. Gubellini, D. Centonze, G. Sancesario, M. Morello, M. Giorgi, A. Pisani, and G. Bernardi
A Critical Role of the Nitric Oxide/cGMP Pathway in Corticostriatal Long-Term Depression
J. Neurosci.,
April 1, 1999;
19(7):
2489 - 2499.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Charpier and J. M. Deniau
In vivo activity-dependent plasticity at cortico-striatal connections: Evidence for physiological long-term potentiation
PNAS,
June 24, 1997;
94(13):
7036 - 7040.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Calabresi, A. Saiardi, A. Pisani, J.-H. Baik, D. Centonze, N. B. Mercuri, G. Bernardi, and E. Borrelli
Abnormal Synaptic Plasticity in the Striatum of Mice Lacking Dopamine D2 Receptors
J. Neurosci.,
June 15, 1997;
17(12):
4536 - 4544.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. C. Pierce and P. W. Kalivas
Repeated Cocaine Modifies the Mechanism by which Amphetamine Releases Dopamine
J. Neurosci.,
May 1, 1997;
17(9):
3254 - 3261.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Calabresi, C. M. Ascone, D. Centonze, A. Pisani, G. Sancesario, V. D'Angelo, and G. Bernardi
Opposite Membrane Potential Changes Induced by Glucose Deprivation in Striatal Spiny Neurons and in Large Aspiny Interneurons
J. Neurosci.,
March 15, 1997;
17(6):
1940 - 1949.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Zhang, J. P. Steiner, G. S. Hamilton, T. P. Hicks, and M. O. Poulter
Regeneration of Dopaminergic Function in 6-Hydroxydopamine-Lesioned Rats by Neuroimmunophilin Ligand Treatment
J. Neurosci.,
August 1, 2001;
21(15):
RC156 - RC156.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
