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Journal of Neuroscience, Vol 14, 5077-5088, Copyright © 1994 by Society for Neuroscience
Dendritic pathology of granule cells in Alzheimer's disease is unrelated to neuritic plaques
G Einstein, R Buranosky and BJ Crain
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710.
Neuritic plaques are the histologic hallmark of Alzheimer's disease (AD);
however, the extent to which they are injurious to neurons is unclear. In
order to investigate this problem, we intracellularly filled human dentate
granule cells with Lucifer yellow in a lightly fixed slice preparation and
studied the relationships between their dendrites and neuritic plaques.
After counterstaining for plaques and drawing the filled granule cell
dendrites, we found that there were significant differences in the
morphology of dendrites in control and AD cases; granule cell dendrites
from Alzheimer's cases were generally shorter, branched less profusely, and
had fewer spines than those from age matched controls. Surprisingly, when
dendrites traveled into plaques, they still bore spines and their
morphology was distinct from that of the amyloid-stained dystrophic
neurites surrounding them. Furthermore, within AD cases we found no
significant differences between dendrites that were located directly
beneath or passing through plaques and those that were located in
plaque-free regions. We conclude that granule cell dendrites are not an
integral component of plaques within their dendritic fields and that
neuritic plaques have no direct effect on granule cells in the dentate
gyrus.
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