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Journal of Neuroscience, Vol 14, 5147-5159, Copyright © 1994 by Society for Neuroscience
Gases as biological messengers: nitric oxide and carbon monoxide in the brain
TM Dawson and SH Snyder
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
In a remarkably brief period of time, NO and CO have been recognized as
putative neurotransmitters. These two novel messenger molecules have
greatly expanded the criteria for candidacy of a chemical for the status of
neurotransmitter and our notions about how synaptic transmission takes
place. The involvement of NO and CO in several important aspects of
neuronal function suggests that agents affecting the synthesis,
transactions, and disposition of these gases are bound to have clinical
relevance.
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