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Journal of Neuroscience, Vol 14, 5281-5291, Copyright © 1994 by Society for Neuroscience
The biological responses of axotomized adult motoneurons to brain- derived neurotrophic factor
Q Yan, C Matheson, OT Lopez and JA Miller
Department of Neurobiology, Amgen, Inc., Amgen Center, Thousand Oaks, CA 91320.
Recent studies showed that brain-derived neurotrophic factor (BDNF)
prevents developing motoneurons from naturally occurring and axotomy-
induced cell death. Here we examined whether adult motoneurons retain
responsiveness to BDNF. Consistent with previous studies, we found that
adult spinal and brainstem motoneurons expressed the mRNA of BDNF receptor,
trkB. In addition, the trkB immunoreactivities were readily detected in the
adult spinal and brainstem motoneurons. We then demonstrated that
axotomized adult motoneurons responded to exogenous BDNF. BDNF administered
locally markedly attenuated the lesion-induced decrease of ChAT
immunoreactivity and activity and enhanced the lesion- induced reexpression
of low-affinity NGF receptor immunoreactivity in adult facial motoneurons.
Furthermore, we found BDNF administered subcutaneously, intravenously, and
into the cerebral ventricle attenuated the lesion-induced decrease of ChAT
immunoreactivity in adult facial motoneurons in a dose-dependent fashion.
Our data indicate that adult motoneurons retain their responsiveness to
BDNF, suggesting that BDNF may be useful as a therapeutic agent for adult
motoneuron disease.
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