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Journal of Neuroscience, Vol 14, 5525-5547, Copyright © 1994 by Society for Neuroscience
Kainate receptor gene expression in the developing rat brain
S Bahn, B Volk and W Wisden
MRC Laboratory of Molecular Biology, Neurobiology Division, Cambridge, United Kingdom.
Kainate-preferring receptors are a subclass of ionotropic glutamate
receptors that might play a role in brain development. The expression of
the five known genes encoding kainate receptor subunits (GluR-5, -6, -7,
KA-1, and KA-2) was studied by in situ hybridization during pre- and
postnatal development of the rat brain. We compared the combined expression
patterns of these genes with autoradiography using 3H- kainate in the
developing brain from embryonic day 12 (E12) through to adult. Although
mRNAs for the receptor subunits (except KA-1) can be detected at stage E12,
3H-kainic acid binding (as an index of receptor protein) is not found at
this stage. However, by E14 high-affinity kainate sites are found
throughout the gray matter, but particularly in spinal cord, primordial
cerebellum, and ventral forebrain structures. All genes undergo a peak in
their expression in the late embryonic/early postnatal period. GluR-5
expression during development shows the most interesting features because
the changes are qualitative. The GluR-5 gene shows peaks of expression
around the period of birth in the sensory cortex (layers II, III, and IV),
in CA1 hippocampal interneurons in the stratum oriens, in the septum, and
in the thalamus. GluR-6 shows a prenatal expression peak in the cingulate
gyrus of the neocortex. KA-1 transcripts appear with the development of the
hippocampus and remain largely confined to discrete areas such as the CA3
region, the dentate gyrus, and subiculum. KA-2 transcripts are found
throughout the CNS from as early as E12 and remain constant until
adulthood. The GluR-5 and GluR-6 genes are coexpressed in multiple
peripheral ganglia (e.g., cranial nerve ganglia, dorsal root ganglia, and
mural ganglia) at E14.
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