QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Konradi, C. Articles by Hyman, S. E. Search for Related Content PubMed PubMed Citation Articles by Konradi, C. Articles by Hyman, S. E.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 14, 5623-5634, Copyright © 1994 by Society for Neuroscience

ARTICLE

Amphetamine regulates gene expression in rat striatum via transcription factor CREB

C Konradi, RL Cole, S Heckers and SE Hyman
Laboratory of Molecular and Developmental Neuroscience, Massachusetts General Hospital, Charlestown 02129.

Amphetamine is a psychostimulant drug of abuse that can produce long- lived changes in behavior including sensitization and dependence. The neural substrates of these drug effects remain unknown, but based on their prolonged time course, we hypothesize that they involve drug- induced alterations in gene expression. It has recently been demonstrated that amphetamine regulates the expression of several genes, including c-fos, via dopamine D1 receptors in rat striatum. Here we report that amphetamine induces phosphorylation of transcription factor cAMP response element binding protein (CREB) in rat striatum in vivo and that dopamine D1 receptor stimulation induces phosphorylation of CREB within specific complexes bound to cAMP regulatory elements. In addition, we show by antisense injection that CREB is necessary for c- fos induction by amphetamine in vivo. Since CREB has been implicated in the activation of a number of immediate-early genes as well as several neuropeptide genes, CREB phosphorylation may be an important early nuclear event mediating long-term consequences of amphetamine administration.

This article has been cited by other articles:

				T. A. Green, I. N. Alibhai, S. Unterberg, R. L. Neve, S. Ghose, C. A. Tamminga, and E. J. Nestler Induction of Activating Transcription Factors (ATFs) ATF2, ATF3, and ATF4 in the Nucleus Accumbens and Their Regulation of Emotional Behavior J. Neurosci., February 27, 2008; 28(9): 2025 - 2032. [Abstract] [Full Text] [PDF]

				J. A. Trafton and E. V. Gifford Behavioral Reactivity and Addiction: The Adaptation of Behavioral Response to Reward Opportunities J Neuropsychiatry Clin Neurosci, February 1, 2008; 20(1): 23 - 35. [Abstract] [Full Text] [PDF]

				C. S. McPherson, T. Featherby, E. Krstew, and J. L. Andrew Quantification of Phosphorylated cAMP-Response Element-Binding Protein Expression throughout the Brain of Amphetamine-Sensitized Rats: Activation of Hypothalamic Orexin A-Containing Neurons J. Pharmacol. Exp. Ther., December 1, 2007; 323(3): 805 - 812. [Abstract] [Full Text] [PDF]

				C. H. Liu, Y. R. Kim, J. Q. Ren, F. Eichler, B. R. Rosen, and P. K. Liu Imaging Cerebral Gene Transcripts in Live Animals J. Neurosci., January 17, 2007; 27(3): 713 - 722. [Abstract] [Full Text] [PDF]

				S. E. Hyman Addiction: A Disease of Learning and Memory Focus, January 1, 2007; 5(2): 220 - 228. [Abstract] [Full Text] [PDF]

				Y.-S. Hsieh, S.-F. Yang, and D.-Y. Kuo Intracerebral administration of protein kinase A or cAMP response element-binding protein antisense oligonucleotide can modulate amphetamine-mediated appetite suppression in free-moving rats Am J Physiol Endocrinol Metab, January 1, 2007; 292(1): E123 - E131. [Abstract] [Full Text] [PDF]

				Y. D. Black, F. R. Maclaren, A. V. Naydenov, W. A. Carlezon Jr, M. G. Baxter, and C. Konradi Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescence. J. Neurosci., September 20, 2006; 26(38): 9656 - 9665. [Abstract] [Full Text] [PDF]

				P. Olausson, J. D. Jentsch, N. Tronson, R. L. Neve, E. J. Nestler, and J. R. Taylor {Delta}FosB in the Nucleus Accumbens Regulates Food-Reinforced Instrumental Behavior and Motivation J. Neurosci., September 6, 2006; 26(36): 9196 - 9204. [Abstract] [Full Text] [PDF]

				T. A. Green, I. N. Alibhai, J. D. Hommel, R. J. DiLeone, A. Kumar, D. E. Theobald, R. L. Neve, and E. J. Nestler Induction of inducible cAMP early repressor expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli. J. Neurosci., August 9, 2006; 26(32): 8235 - 8242. [Abstract] [Full Text] [PDF]

				S. E. Hyman Addiction: A Disease of Learning and Memory Am J Psychiatry, August 1, 2005; 162(8): 1414 - 1422. [Abstract] [Full Text] [PDF]

				C. L. Heusner and R. D. Palmiter Expression of Mutant NMDA Receptors in Dopamine D1 Receptor-Containing Cells Prevents Cocaine Sensitization and Decreases Cocaine Preference J. Neurosci., July 13, 2005; 25(28): 6651 - 6657. [Abstract] [Full Text] [PDF]

				V. G. Olson, C. P. Zabetian, C. A. Bolanos, S. Edwards, M. Barrot, A. J. Eisch, T. Hughes, D. W. Self, R. L. Neve, and E. J. Nestler Regulation of Drug Reward by cAMP Response Element-Binding Protein: Evidence for Two Functionally Distinct Subregions of the Ventral Tegmental Area J. Neurosci., June 8, 2005; 25(23): 5553 - 5562. [Abstract] [Full Text] [PDF]

				M. Barrot, D. L. Wallace, C. A. Bolanos, D. L. Graham, L. I. Perrotti, R. L. Neve, H. Chambliss, J. C. Yin, and E. J. Nestler Regulation of anxiety and initiation of sexual behavior by CREB in the nucleus accumbens PNAS, June 7, 2005; 102(23): 8357 - 8362. [Abstract] [Full Text] [PDF]

				S. Tancharoen, K. P. Sarker, T. Imamura, K. K. Biswas, K. Matsushita, S. Tatsuyama, J. Travis, J. Potempa, M. Torii, and I. Maruyama Neuropeptide Release from Dental Pulp Cells by RgpB via Proteinase-Activated Receptor-2 Signaling J. Immunol., May 1, 2005; 174(9): 5796 - 5804. [Abstract] [Full Text] [PDF]

				E. Valjent, V. Pascoli, P. Svenningsson, S. Paul, H. Enslen, J.-C. Corvol, A. Stipanovich, J. Caboche, P. J. Lombroso, A. C. Nairn, et al. From The Cover: Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum PNAS, January 11, 2005; 102(2): 491 - 496. [Abstract] [Full Text] [PDF]

				P. Jouvert, M.-O. Revel, A. Lazaris, D. Aunis, K. Langley, and J. Zwiller Activation of the cGMP Pathway in Dopaminergic Structures Reduces Cocaine-Induced EGR-1 Expression and Locomotor Activity J. Neurosci., November 24, 2004; 24(47): 10716 - 10725. [Abstract] [Full Text] [PDF]

				W. A. Link, F. Ledo, B. Torres, M. Palczewska, T. M. Madsen, M. Savignac, J. P. Albar, B. Mellstrom, and J. R. Naranjo Day-Night Changes in Downstream Regulatory Element Antagonist Modulator/Potassium Channel Interacting Protein Activity Contribute to Circadian Gene Expression in Pineal Gland J. Neurosci., June 9, 2004; 24(23): 5346 - 5355. [Abstract] [Full Text] [PDF]

				L. Zhang, D. Lou, H. Jiao, D. Zhang, X. Wang, Y. Xia, J. Zhang, and M. Xu Cocaine-Induced Intracellular Signaling and Gene Expression Are Oppositely Regulated by the Dopamine D1 and D3 Receptors J. Neurosci., March 31, 2004; 24(13): 3344 - 3354. [Abstract] [Full Text] [PDF]

				L. Zhao and R. D. Brinton Suppression of Proinflammatory Cytokines Interleukin-1{beta} and Tumor Necrosis Factor-{alpha} in Astrocytes by a V1 Vasopressin Receptor Agonist: A cAMP Response Element-Binding Protein-Dependent Mechanism J. Neurosci., March 3, 2004; 24(9): 2226 - 2235. [Abstract] [Full Text] [PDF]

				C. R. Gerfen D1 Dopamine Receptor Supersensitivity in the Dopamine-Depleted Striatum Animal Model of Parkinson's Disease Neuroscientist, December 1, 2003; 9(6): 455 - 462. [Abstract] [PDF]

				K. Brami-Cherrier, E. Valjent, M. Garcia, C. Pages, R. A. Hipskind, and J. Caboche Dopamine Induces a PI3-Kinase-Independent Activation of Akt in Striatal Neurons: A New Route to cAMP Response Element-Binding Protein Phosphorylation J. Neurosci., October 15, 2002; 22(20): 8911 - 8921. [Abstract] [Full Text] [PDF]

				L. Mao and J. Q. Wang Glutamate Cascade to cAMP Response Element-Binding Protein Phosphorylation in Cultured Striatal Neurons through Calcium-Coupled Group I Metabotropic Glutamate Receptors Mol. Pharmacol., September 1, 2002; 62(3): 473 - 484. [Abstract] [Full Text] [PDF]

				M. Barrot, J. D. A. Olivier, L. I. Perrotti, R. J. DiLeone, O. Berton, A. J. Eisch, S. Impey, D. R. Storm, R. L. Neve, J. C. Yin, et al. CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli PNAS, August 20, 2002; 99(17): 11435 - 11440. [Abstract] [Full Text] [PDF]

				C. R. Gerfen, S. Miyachi, R. Paletzki, and P. Brown D1 Dopamine Receptor Supersensitivity in the Dopamine-Depleted Striatum Results from a Switch in the Regulation of ERK1/2/MAP Kinase J. Neurosci., June 15, 2002; 22(12): 5042 - 5054. [Abstract] [Full Text] [PDF]

				T. M. Reed, D. R. Repaske, G. L. Snyder, P. Greengard, and C. V. Vorhees Phosphodiesterase 1B Knock-Out Mice Exhibit Exaggerated Locomotor Hyperactivity and DARPP-32 Phosphorylation in Response to Dopamine Agonists and Display Impaired Spatial Learning J. Neurosci., June 15, 2002; 22(12): 5188 - 5197. [Abstract] [Full Text] [PDF]

				N. Sakai, J. Thome, S. S. Newton, J. Chen, M. B. Kelz, C. Steffen, E. J. Nestler, and R. S. Duman Inducible and Brain Region-Specific CREB Transgenic Mice Mol. Pharmacol., June 1, 2002; 61(6): 1453 - 1464. [Abstract] [Full Text] [PDF]

				M. Andersson, C. Konradi, and M. A. Cenci cAMP Response Element-Binding Protein Is Required for Dopamine-Dependent Gene Expression in the Intact But Not the Dopamine-Denervated Striatum J. Neurosci., December 15, 2001; 21(24): 9930 - 9943. [Abstract] [Full Text] [PDF]

				E. J. Yang, Y. S. Ahn, and K. C. Chung Protein Kinase Dyrk1 Activates cAMP Response Element-binding Protein during Neuronal Differentiation in Hippocampal Progenitor Cells J. Biol. Chem., October 19, 2001; 276(43): 39819 - 39824. [Abstract] [Full Text] [PDF]

				T. Nikaido, M. Akiyama, T. Moriya, and S. Shibata Sensitized Increase of Period Gene Expression in the Mouse Caudate/Putamen Caused by Repeated Injection of Methamphetamine Mol. Pharmacol., April 1, 2001; 59(4): 894 - 900. [Abstract] [Full Text]

				E. Valjent, J.-C. Corvol, C. Pages, M.-J. Besson, R. Maldonado, and J. Caboche Involvement of the Extracellular Signal-Regulated Kinase Cascade for Cocaine-Rewarding Properties J. Neurosci., December 1, 2000; 20(23): 8701 - 8709. [Abstract] [Full Text] [PDF]

				D. S. Kim, M. S. Szczypka, and R. D. Palmiter Dopamine-Deficient Mice Are Hypersensitive to Dopamine Receptor Agonists J. Neurosci., June 15, 2000; 20(12): 4405 - 4413. [Abstract] [Full Text] [PDF]

				J. F. Guzowski, G. L. Lyford, G. D. Stevenson, F. P. Houston, J. L. McGaugh, P. F. Worley, and C. A. Barnes Inhibition of Activity-Dependent Arc Protein Expression in the Rat Hippocampus Impairs the Maintenance of Long-Term Potentiation and the Consolidation of Long-Term Memory J. Neurosci., June 1, 2000; 20(11): 3993 - 4001. [Abstract] [Full Text] [PDF]

				P. Svenningsson, M. Lindskog, C. Ledent, M. Parmentier, P. Greengard, B. B. Fredholm, and G. Fisone Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine D1, dopamine D2, and adenosine A2A receptors PNAS, February 15, 2000; 97(4): 1856 - 1860. [Abstract] [Full Text] [PDF]

				M.-Y. Jung and C. Schmauss Decreased c-fos Responses to Dopamine D1 Receptor Agonist Stimulation in Mice Deficient for D3 Receptors J. Biol. Chem., October 8, 1999; 274(41): 29406 - 29412. [Abstract] [Full Text] [PDF]

				L. Just, C. Olenik, and D.K. Meyer Neocortical Projections Regulate the Neostriatal Proenkephalin Gene Expression Cereb Cortex, June 1, 1999; 9(4): 332 - 339. [Abstract] [Full Text] [PDF]

				B. B. Fredholm, K. Battig, J. Holmen, A. Nehlig, and E. E. Zvartau Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use Pharmacol. Rev., March 1, 1999; 51(1): 83 - 133. [Abstract] [Full Text] [PDF]

				A. Badiani, M. M. Oates, H. E. W. Day, S. J. Watson, H. Akil, and T. E. Robinson Amphetamine-Induced Behavior, Dopamine Release, and c-fos mRNA Expression: Modulation by Environmental Novelty J. Neurosci., December 15, 1998; 18(24): 10579 - 10593. [Abstract] [Full Text] [PDF]

				A. A. Fienberg, N. Hiroi, P. G. Mermelstein, W. Song, G. L. Snyder, A. Nishi, A. Cheramy, J. P. O'Callaghan, D. B. Miller, D. G. Cole, et al. DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission Science, August 7, 1998; 281(5378): 838 - 842. [Abstract] [Full Text]

				J. D. Berke, R. F. Paletzki, G. J. Aronson, S. E. Hyman, and C. R. Gerfen A Complex Program of Striatal Gene Expression Induced by Dopaminergic Stimulation J. Neurosci., July 15, 1998; 18(14): 5301 - 5310. [Abstract] [Full Text] [PDF]

				D. L. Feldpausch, L. M. Needham, M. P. Stone, J. S. Althaus, B. K. Yamamoto, K. A. Svensson, and K. M. Merchant The Role of Dopamine D4 Receptor in the Induction of Behavioral Sensitization to Amphetamine and Accompanying Biochemical and Molecular Adaptations J. Pharmacol. Exp. Ther., July 1, 1998; 286(1): 497 - 508. [Abstract] [Full Text]

				F.-C. Liu and A. M. Graybiel Region-dependent dynamics of cAMP response element-binding protein phosphorylation in the basal ganglia PNAS, April 14, 1998; 95(8): 4708 - 4713. [Abstract] [Full Text] [PDF]

				C. Spiro and C. T. McMurray Switching of DNA Secondary Structure in Proenkephalin Transcriptional Regulation J. Biol. Chem., December 26, 1997; 272(52): 33145 - 33152. [Abstract] [Full Text] [PDF]

				R. Lamprecht, S. Hazvi, and Y. Dudai cAMP Response Element-Binding Protein in the Amygdala Is Required for Long- but not Short-Term Conditioned Taste Aversion Memory J. Neurosci., November 1, 1997; 17(21): 8443 - 8450. [Abstract] [Full Text] [PDF]

				J. Y. H. Chan, C.-D. Shih, and S. H. H. Chan Enhancement of spontaneous baroreflex by antisense c-fos oligonucleotide treatment in the NTS of the rat Am J Physiol Heart Circ Physiol, November 1, 1997; 273(5): H2200 - H2208. [Abstract] [Full Text] [PDF]

				S. B. Lane-Ladd, J. Pineda, V. A. Boundy, T. Pfeuffer, J. Krupinski, G. K. Aghajanian, and E. J. Nestler CREB (cAMP Response Element-Binding Protein) in the Locus Coeruleus: Biochemical, Physiological, and Behavioral Evidence for a Role in Opiate Dependence J. Neurosci., October 15, 1997; 17(20): 7890 - 7901. [Abstract] [Full Text] [PDF]

				M. A. Schwarzschild, R. L. Cole, and S. E. Hyman Glutamate, But Not Dopamine, Stimulates Stress-Activated Protein Kinase and AP-1-Mediated Transcription in Striatal Neurons J. Neurosci., May 15, 1997; 17(10): 3455 - 3466. [Abstract] [Full Text] [PDF]

				J. F. Guzowski and J. L. McGaugh Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training PNAS, March 18, 1997; 94(6): 2693 - 2698. [Abstract] [Full Text] [PDF]

				R.-R. Ji and F. Rupp Phosphorylation of Transcription Factor CREB in Rat Spinal Cord after Formalin-Induced Hyperalgesia: Relationship to c-fos Induction J. Neurosci., March 1, 1997; 17(5): 1776 - 1785. [Abstract] [Full Text] [PDF]

				C. Tinti, B. Conti, J. F. Cubells, K.-S. Kim, H. Baker, and T. H. Joh Inducible cAMP Early Repressor Can Modulate Tyrosine Hydroxylase Gene Expression after Stimulation of cAMP Synthesis J. Biol. Chem., October 11, 1996; 271(41): 25375 - 25381. [Abstract] [Full Text] [PDF]

				C. Konradi, J.-C. Leveque, and S. E. Hyman Amphetamine and Dopamine-Induced Immediate Early Gene Expression in Striatal Neurons Depends on Postsynaptic NMDA Receptors and Calcium J. Neurosci., July 1, 1996; 16(13): 4231 - 4239. [Abstract] [Full Text] [PDF]

				A. N. Moore, M. N. Waxham, and P. K. Dash Neuronal Activity Increases the Phosphorylation of the Transcription Factor cAMP Response Element-binding Protein (CREB) in Rat Hippocampus and Cortex J. Biol. Chem., June 14, 1996; 271(24): 14214 - 14220. [Abstract] [Full Text] [PDF]

				T. Herdegen REVIEW {blacksquare} : Jun, Fos, and CREB/ATF Transcription Factors in the Brain: Control of Gene Expression under Normal and Pathophysiological Conditions Neuroscientist, May 1, 1996; 2(3): 153 - 161. [Abstract] [PDF]

				C. Spiro, D. P. Bazett-Jones, X. Wu, and C. T. McMurray DNA Structure Determines Protein Binding and Transcriptional Efficiency of the Proenkephalin cAMP-responsive Enhancer J. Biol. Chem., November 17, 1995; 270(46): 27702 - 27710. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help