 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 15, 230-240, Copyright © 1995 by Society for Neuroscience
Antagonist and partial agonist actions of d-tubocurarine at mammalian muscle acetylcholine receptors
JH Steinbach and Q Chen
Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110.
Currents were elicited by acetylcholine (ACh), by d-tubocurarine (dTC), and
by mixtures of ACh and dTC, from stably transformed fibroblasts that
express fetal or adult muscle nicotinic receptors. dTC acted as an
antagonist of ACh for activation of adult-type receptors, whereas it acted
as a weak partial agonist at fetal-type receptors. The channel- blocking
action of dTC was not apparent at the concentrations used. The partial
agonism could explain previous observations that dTC is less effective at
blocking the responses of fetal-type receptors than adult- type receptors.
Binding of dTC to receptors was independently assayed by measuring the
reduction of the initial rate of binding of iodinated alpha-bungarotoxin.
Binding of dTC to the two types of receptor was indistinguishable. The
dose-effect relationship for the interaction of dTC and ACh at fetal
receptors is consistent with the affinities of dTC measured in binding
experiments.
This article has been cited by other articles:
|
|
|
|
 
D. Demazumder and J. P. Dilger
The kinetics of competitive antagonism of nicotinic acetylcholine receptors at physiological temperature
J. Physiol.,
February 15, 2008;
586(4):
951 - 963.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Bartos, D. Rayes, and C. Bouzat
Molecular Determinants of Pyrantel Selectivity in Nicotinic Receptors
Mol. Pharmacol.,
October 1, 2006;
70(4):
1307 - 1318.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Akk, L. S Milescu, and M. Heckmann
Activation of heteroliganded mouse muscle nicotinic receptors
J. Physiol.,
April 15, 2005;
564(2):
359 - 376.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-L. Wang, F. Gao, N. Bren, and S. M. Sine
Curariform Antagonists Bind in Different Orientations to the Nicotinic Receptor Ligand Binding Domain
J. Biol. Chem.,
August 22, 2003;
278(34):
32284 - 32291.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Zuo, J. Z. Yeh, and T. Narahashi
Dual Action of n-Butanol on Neuronal Nicotinic alpha 4beta 2 Acetylcholine Receptors
J. Pharmacol. Exp. Ther.,
March 1, 2003;
304(3):
1143 - 1152.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Wenningmann and J. P. Dilger
The Kinetics of Inhibition of Nicotinic Acetylcholine Receptors by (+)-Tubocurarine and Pancuronium
Mol. Pharmacol.,
October 1, 2001;
60(4):
790 - 796.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Ibebunjo and J. A. J. Martyn
Thermal Injury Induces Greater Resistance to d-Tubocurarine in Local Rather than in Distant Muscles in the Rat
Anesth. Analg.,
October 1, 2000;
91(5):
1243 - 1249.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Lubischer and W. J. Thompson
Neonatal Partial Denervation Results in Nodal But Not Terminal Sprouting and a Decrease in Efficacy of Remaining Neuromuscular Junctions in Rat Soleus Muscle
J. Neurosci.,
October 15, 1999;
19(20):
8931 - 8944.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Kurata, W. Marszalec, J. Z. Yeh, and T. Narahashi
Agonist and Potentiation Actions of n-Octanol on gamma -Aminobutyric Acid Type A Receptors
Mol. Pharmacol.,
June 1, 1999;
55(6):
1011 - 1019.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C. Ibebunjo, M. T. Nosek, M. S. Itani, and J. A. J. Martyn
Mechanisms for the Paradoxical Resistance to d-Tubocurarine during Immobilization-Induced Muscle Atrophy
J. Pharmacol. Exp. Ther.,
November 1, 1997;
283(2):
443 - 451.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Y. Xie and J. B. Cohen
Contributions of Torpedo Nicotinic Acetylcholine Receptor gamma Trp-55 and delta Trp-57 to Agonist and Competitive Antagonist Function
J. Biol. Chem.,
January 19, 2001;
276(4):
2417 - 2426.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Eddins, L. K. Lyford, J. W. Lee, S. A. Desai, and R. L. Rosenberg
Permeant but not impermeant divalent cations enhance activation of nondesensitizing alpha 7 nicotinic receptors
Am J Physiol Cell Physiol,
April 1, 2002;
282(4):
C796 - C804.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
