 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 15, 458-469, Copyright © 1995 by Society for Neuroscience
Muscarinic receptors modulate N-, P-, and L-type Ca2+ currents in rat striatal neurons through parallel pathways
AR Howe and DJ Surmeier
Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis 38163.
Muscarinic modulation of calcium currents was studied in acutely isolated
striatal neurons from the adult rat using the whole-cell configuration of
the patch-clamp technique. Muscarinic agonists reduced calcium currents
through two distinct signaling pathways. One pathway depended upon
PTX-sensitive G-proteins and targeted N- and P-type currents. The other
pathway depended upon PTX-insensitive G-proteins and was rendered inactive
by high intracellular concentrations of BAPTA and targeted L-type currents.
The modulation of N- and P-type currents was relieved by strong
depolarizing prepulses, whereas the modulation of L-type currents was not.
These findings support the proposition that parallel signaling pathways
exist between muscarinic receptors and calcium channels.
This article has been cited by other articles:
|
|
|
|
 
P. Bonsi, G. Martella, D. Cuomo, P. Platania, G. Sciamanna, G. Bernardi, J. Wess, and A. Pisani
Loss of Muscarinic Autoreceptor Function Impairs Long-Term Depression But Not Long-Term Potentiation in the Striatum
J. Neurosci.,
June 11, 2008;
28(24):
6258 - 6263.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Narushima, M. Uchigashima, M. Fukaya, M. Matsui, T. Manabe, K. Hashimoto, M. Watanabe, and M. Kano
Tonic Enhancement of Endocannabinoid-Mediated Retrograde Suppression of Inhibition by Cholinergic Interneuron Activity in the Striatum
J. Neurosci.,
January 17, 2007;
27(3):
496 - 506.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Yang, A. D. Sumner, H. L. Puhl, and V. Ruiz-Velasco
M1 and M2 Muscarinic Acetylcholine Receptor Subtypes Mediate Ca2+ Channel Current Inhibition in Rat Sympathetic Stellate Ganglion Neurons
J Neurophysiol,
November 1, 2006;
96(5):
2479 - 2487.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. G. Cook, X. Li, S. D. Cherry, and A. R. Cantrell
Presenilin 1 Deficiency Alters the Activity of Voltage-Gated Ca2+ Channels in Cultured Cortical Neurons
J Neurophysiol,
December 1, 2005;
94(6):
4421 - 4429.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Perez-Rosello, A. Figueroa, H. Salgado, C. Vilchis, F. Tecuapetla, J. N. Guzman, E. Galarraga, and J. Bargas
Cholinergic Control of Firing Pattern and Neurotransmission in Rat Neostriatal Projection Neurons: Role of CaV2.1 and CaV2.2 Ca2+ Channels
J Neurophysiol,
May 1, 2005;
93(5):
2507 - 2519.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Olson, T. Tkatch, S. Hernandez-Lopez, S. Ulrich, E. Ilijic, E. Mugnaini, H. Zhang, I. Bezprozvanny, and D. J. Surmeier
G-Protein-Coupled Receptor Modulation of Striatal CaV1.3 L-Type Ca2+ Channels Is Dependent on a Shank-Binding Domain
J. Neurosci.,
February 2, 2005;
25(5):
1050 - 1062.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. V. Rakhilin, P. A. Olson, A. Nishi, N. N. Starkova, A. A. Fienberg, A. C. Nairn, D. J. Surmeier, and P. Greengard
A Network of Control Mediated by Regulator of Calcium/Calmodulin-Dependent Signaling
Science,
October 22, 2004;
306(5696):
698 - 701.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T.-S. Tang and I. Bezprozvanny
Dopamine Receptor-mediated Ca2+ Signaling in Striatal Medium Spiny Neurons
J. Biol. Chem.,
October 1, 2004;
279(40):
42082 - 42094.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F.-M. Zhou, C. Wilson, and J. A. Dani
Muscarinic and Nicotinic Cholinergic Mechanisms in the Mesostriatal Dopamine Systems
Neuroscientist,
February 1, 2003;
9(1):
23 - 36.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. A. Bannister, K. Melliti, and B. A. Adams
Reconstituted Slow Muscarinic Inhibition of Neuronal (CaV1.2c) L-Type Ca2+ Channels
Biophys. J.,
December 1, 2002;
83(6):
3256 - 3267.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Kim, M. Isokawa, C. Ledent, and B. E. Alger
Activation of Muscarinic Acetylcholine Receptors Enhances the Release of Endogenous Cannabinoids in the Hippocampus
J. Neurosci.,
December 1, 2002;
22(23):
10182 - 10191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Zhang, M. Yamada, J. Gomeza, A. S. Basile, and J. Wess
Multiple Muscarinic Acetylcholine Receptor Subtypes Modulate Striatal Dopamine Release, as Studied with M1-M5 Muscarinic Receptor Knock-Out Mice
J. Neurosci.,
August 1, 2002;
22(15):
6347 - 6352.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Day, P. A. Olson, J. Platzer, J. Striessnig, and D. J. Surmeier
Stimulation of 5-HT2 Receptors in Prefrontal Pyramidal Neurons Inhibits Cav1.2 L-Type Ca2+ Currents Via a PLCbeta /IP3/Calcineurin Signaling Cascade
J Neurophysiol,
May 1, 2002;
87(5):
2490 - 2504.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Koos and J. M. Tepper
Dual Cholinergic Control of Fast-Spiking Interneurons in the Neostriatum
J. Neurosci.,
January 15, 2002;
22(2):
529 - 535.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Scroggs, C. G. Cardenas, J. A. Whittaker, and S. T. Kitai
Muscarine Reduces Calcium-Dependent Electrical Activity in Substantia Nigra Dopaminergic Neurons
J Neurophysiol,
December 1, 2001;
86(6):
2966 - 2972.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Wicher
Peptidergic Modulation of Insect Voltage-Gated Ca2+ Currents: Role of Resting Ca2+ Current and Protein Kinases A and C
J Neurophysiol,
November 1, 2001;
86(5):
2353 - 2362.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Gilon and J.-C. Henquin
Mechanisms and Physiological Significance of the Cholinergic Control of Pancreatic {beta}-Cell Function
Endocr. Rev.,
October 1, 2001;
22(5):
565 - 604.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Silva-Barrat, M. Szente, Ch. Menini, J. C. Velluti, and J. Champagnat
Muscarinic Depression of Synaptic Transmission in the Epileptogenic GABA Withdrawal Syndrome Focus
J Neurophysiol,
May 1, 2001;
85(5):
2159 - 2165.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Hernandez-Lopez, T. Tkatch, E. Perez-Garci, E. Galarraga, J. Bargas, H. Hamm, and D. J. Surmeier
D2 Dopamine Receptors in Striatal Medium Spiny Neurons Reduce L-Type Ca2+ Currents and Excitability via a Novel PLC{beta}1-IP3-Calcineurin-Signaling Cascade
J. Neurosci.,
December 15, 2000;
20(24):
8987 - 8995.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. C. Foehring, P. G. Mermelstein, W.-J. Song, S. Ulrich, and D. J. Surmeier
Unique Properties of R-Type Calcium Currents in Neocortical and Neostriatal Neurons
J Neurophysiol,
November 1, 2000;
84(5):
2225 - 2236.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Cantrell, T. Scheuer, and W. A. Catterall
Voltage-Dependent Neuromodulation of Na+ Channels by D1-Like Dopamine Receptors in Rat Hippocampal Neurons
J. Neurosci.,
July 1, 1999;
19(13):
5301 - 5310.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. D. Bennett and C. J. Wilson
Spontaneous Activity of Neostriatal Cholinergic Interneurons In Vitro
J. Neurosci.,
July 1, 1999;
19(13):
5586 - 5596.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Galarraga, S. Hernandez-Lopez, A. Reyes, I. Miranda, F. Bermudez-Rattoni, C. Vilchis, and J. Bargas
Cholinergic Modulation of Neostriatal Output: A Functional Antagonism between Different Types of Muscarinic Receptors
J. Neurosci.,
May 1, 1999;
19(9):
3629 - 3638.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. A. Gabel and E. S. Nisenbaum
Muscarinic Receptors Differentially Modulate the Persistent Potassium Current in Striatal Spiny Projection Neurons
J Neurophysiol,
March 1, 1999;
81(3):
1418 - 1423.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Stewart, Z. Yan, D. J. Surmeier, and R. C. Foehring
Muscarine Modulates Ca2+ Channel Currents in Rat Sensorimotor Pyramidal Cells Via Two Distinct Pathways
J Neurophysiol,
January 1, 1999;
81(1):
72 - 84.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Rawls and J. F. Mcginty
Muscarinic Receptors Regulate Extracellular Glutamate Levels in the Rat Striatum: An In Vivo Microdialysis Study
J. Pharmacol. Exp. Ther.,
July 1, 1998;
286(1):
91 - 98.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
L. A. McCullough, T. M. Egan, and T. C. Westfall
Neuropeptide Y inhibition of calcium channels in PC-12 pheochromocytoma cells
Am J Physiol Cell Physiol,
May 1, 1998;
274(5):
C1290 - C1297.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Cantrell, R. D. Smith, A. L. Goldin, T. Scheuer, and W. A. Catterall
Dopaminergic Modulation of Sodium Current in Hippocampal Neurons via cAMP-Dependent Phosphorylation of Specific Sites in the Sodium Channel alpha Subunit
J. Neurosci.,
October 1, 1997;
17(19):
7330 - 7338.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Margeta-Mitrovic, J. J. Grigg, K. Koyano, Y. Nakajima, and S. Nakajima
Neurotensin and Substance P Inhibit Low- and High-Voltage-Activated Ca2+ Channels in Cultured Newborn Rat Nucleus Basalis Neurons
J Neurophysiol,
September 1, 1997;
78(3):
1341 - 1352.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-W. Jeong and R. D. Wurster
Muscarinic Receptor Activation Modulates Ca2+ Channels in Rat Intracardiac Neurons via a PTX- and Voltage-Sensitive Pathway
J Neurophysiol,
September 1, 1997;
78(3):
1476 - 1490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. G. Cardenas, L. P. D. Mar, and R. S. Scroggs
Two Parallel Signaling Pathways Couple 5HT1A Receptors to N- and L-Type Calcium Channels in C-Like Rat Dorsal Root Ganglion Cells
J Neurophysiol,
June 1, 1997;
77(6):
3284 - 3296.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Klink and A. Alonso
Muscarinic Modulation of the Oscillatory and Repetitive Firing Properties of Entorhinal Cortex Layer II Neurons
J Neurophysiol,
April 1, 1997;
77(4):
1813 - 1828.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Yan, W.-J. Song, and D. J. Surmeier
D2 Dopamine Receptors Reduce N-Type Ca2+ Currents in Rat Neostriatal Cholinergic Interneurons Through a Membrane-Delimited, Protein-Kinase-C-Insensitive Pathway
J Neurophysiol,
February 1, 1997;
77(2):
1003 - 1015.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Cantrell, V. C. Tibbs, R. E. Westenbroek, T. Scheuer, and W. A. Catterall
Dopaminergic Modulation of Voltage-Gated Na+ Current in Rat Hippocampal Neurons Requires Anchoring of cAMP-Dependent Protein Kinase
J. Neurosci.,
September 1, 1999;
19(17):
RC21 - RC21.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Raz, V. Frechter-Mazar, A. Feingold, M. Abeles, E. Vaadia, and H. Bergman
Activity of Pallidal and Striatal Tonically Active Neurons Is Correlated in MPTP-Treated Monkeys But Not in Normal Monkeys
J. Neurosci.,
February 1, 2001;
21(3):
RC128 - RC128.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
