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Journal of Neuroscience, Vol 15, 477-491, Copyright © 1995 by Society for Neuroscience

ARTICLE

Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins

DL Shelton, J Sutherland, J Gripp, T Camerato, MP Armanini, HS Phillips, K Carroll, SD Spencer and AD Levinson
Department of Neuroscience, Genentech, Inc., South San Francisco, California 94080.

Using molecular cloning techniques, human homologs of the known members of the trk family of neurotrophin receptors have been cloned and sequenced. Overall, there is a high degree of similarity between the human sequences and those from other mammals; however, there are differences in splicing patterns. There are two spliced forms of the extracellular domain of trkC in the human, a finding that has not been described in other species. In contrast, fewer spliced forms were detected of the intracellular domains of human trkB and trkC than has been described in other mammals. Northern analysis and in situ hybridization experiments indicate that the human trks are expressed in a similar pattern to that described in other mammals. Expression of the trk extracellular domains as fusion proteins with IgG heavy chain yields soluble molecules that mimic intact trks in their binding specificity and affinity. These soluble chimeras block the biological activity of their cognate neurotrophin(s) in vitro.


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 Circ. Res.Home page
J. O. Hiltunen, U. Arumae, M. Moshnyakov, and M. Saarma
Expression of mRNAs for Neurotrophins and Their Receptors in Developing Rat Heart
Circ. Res., November 1, 1996; 79(5): 930 - 939.
[Abstract] [Full Text]

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 Proc. Natl. Acad. Sci. USAHome page
J. R. Chan, J. M. Cosgaya, Y. J. Wu, and E. M. Shooter
Inaugural Article: Neurotrophins are key mediators of the myelination program in the peripheral nervous system
PNAS, December 4, 2001; 98(25): 14661 - 14668.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
K. R. Leslie, S. B. Nelson, and G. G. Turrigiano
Postsynaptic Depolarization Scales Quantal Amplitude in Cortical Pyramidal Neurons
J. Neurosci., October 1, 2001; 21(19): RC170 - RC170.
[Abstract] [Full Text] [PDF]


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