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Journal of Neuroscience, Vol 15, 549-561, Copyright © 1995 by Society for Neuroscience
Topological precision in the thalamic projection to neonatal mouse barrel cortex
A Agmon, LT Yang, EG Jones and DK O'Dowd
Department of Anatomy and Neurobiology, University of California, Irvine 92717.
Somatosensory thalamus and cortex in rodents contain topological
representations of the facial whisker pad. The thalamic representation of a
single whisker ("barreloid") is presumed to project exclusively to the
cortical representation ("barrel") of the same whisker; however, it was not
known when this correspondence is established during early development, nor
how precise the thalamocortical projection is at birth, before formation of
barrels and barreloids. To answer these questions, we retrogradely labeled
thalamocortical projection neurons in fixed brain slices from 0-8 d old
(P0-P8) mice, by placing paired deposits of two fluorescent dyes in
adjacent barrels or (before barrel formation) in adjacent loci in upper
cortical layers. At all ages studied, a negligible fraction of the
retrogradely labeled cells was double labeled, implying that branches of
single thalamocortical axons never extended within layer IV over an area
wider than a single barrel. In P0 preparations, 70% of paired dye deposits
placed 75-200 microns apart resulted in statistically significant
segregation of labeled cell clusters in the thalamus. Quantitative analysis
indicated that on P0 about 70% of thalamocortical axons were within 1.3
presumptive barrel diameters from their topologically precise target. In
P4-P8 preparations, the great majority of thalamic cells retrogradely
labeled from a single barrel were found in a single barreloid, implying a
1:1 projection of barreloids to barrels. The postnatal increase in
topological precision was reproduced by a computer simulation, which
assumed that many aberrant axons corrected their initial targeting error by
extending terminal arborizations asymmetrically, towards the center of
their appropriate barrel.
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