 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 15, 6389-6402, Copyright © 1995 by Society for Neuroscience
The first retinal axon growth in the mouse optic chiasm: axon patterning and the cellular environment
RC Marcus and CA Mason
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
The retinofugal pathway is a useful model for axon guidance because fibers
from each eye project to targets on both sides of the brain. Studies using
static and real time analyses in mice at E15-17 demonstrated that uncrossed
axons from ventrotemporal retina diverge from crossed axons in the optic
chiasm, where specialized resident cells may direct divergence. Other
studies, however, suggest that pioneering uncrossed retinal axons derive
from a different retinal region, take a different course, and enter the
ipsilateral optic tract independent of fiber-fiber interactions. We examine
these differences by dye-labeling the earliest optic axons and
immunocytochemically identifying cells in their path. The first optic axons
arising from dorsocentral retina, enter the diencephalon at E12.5. All
axons initially grow caudally, lateral to a radial glial palisade. In
contrast to later growing axons, early uncrossed axons enter the
ipsilateral optic tract directly. Crossed axons enter the glial palisade
and course medially, then anteriorly, in a pathway corresponding to the
border of an early neuronal population that expresses SSEA-1, CD44, and
beta-tubulin. Axon patterning occurs independent of fiber-fiber
interactions from both eyes, as the first uncrossed axons enter the optic
tract before crossed ones from opposite eye. These analysis, in conjunction
with our previous studies during the principal period of retinal axon
growth in the diencephalon, suggest that the adult visual projection arises
from age-dependent variations in the types and relative contribution of
cues along the path through the emerging optic chiasm.
This article has been cited by other articles:
|
|
|
|
 
N. M. Tian, T. Pratt, and D. J. Price
Foxg1 regulates retinal axon pathfinding by repressing an ipsilateral program in nasal retina and by causing optic chiasm cells to exert a net axonal growth-promoting activity
Development,
December 15, 2008;
135(24):
4081 - 4089.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Sanchez-Camacho and P. Bovolenta
Autonomous and non-autonomous Shh signalling mediate the in vivo growth and guidance of mouse retinal ganglion cell axons
Development,
November 1, 2008;
135(21):
3531 - 3541.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Pan, M. Deng, X. Xie, and L. Gan
ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells
Development,
June 1, 2008;
135(11):
1981 - 1990.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Pratt, C. D. Conway, N. M. M.-L. Tian, D. J. Price, and J. O. Mason
Heparan sulphation patterns generated by specific heparan sulfotransferase enzymes direct distinct aspects of retinal axon guidance at the optic chiasm.
J. Neurosci.,
June 28, 2006;
26(26):
6911 - 6923.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. W. Wang, X. Mu, W. J. Bowers, D.-S. Kim, D. J. Plas, M. C. Crair, H. J. Federoff, L. Gan, and W. H. Klein
Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth
Development,
March 3, 2003;
129(2):
467 - 477.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Rachel, G. Dolen, N. L. Hayes, A. Lu, L. Erskine, R. S. Nowakowski, and C. A. Mason
Spatiotemporal Features of Early Neuronogenesis Differ in Wild-Type and Albino Mouse Retina
J. Neurosci.,
June 1, 2002;
22(11):
4249 - 4263.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Jeffery
Architecture of the Optic Chiasm and the Mechanisms That Sculpt Its Development
Physiol Rev,
October 1, 2001;
81(4):
1393 - 1414.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. M. Surace, B. Angeletti, A. Ballabio, and V. Marigo
Expression Pattern of the Ocular Albinism Type 1 (Oa1) Gene in the Murine Retinal Pigment Epithelium
Invest. Ophthalmol. Vis. Sci.,
December 1, 2000;
41(13):
4333 - 4337.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
L. Erskine, S. E. Williams, K. Brose, T. Kidd, R. A. Rachel, C. S. Goodman, M. Tessier-Lavigne, and C. A. Mason
Retinal Ganglion Cell Axon Guidance in the Mouse Optic Chiasm: Expression and Function of Robos and Slits
J. Neurosci.,
July 1, 2000;
20(13):
4975 - 4982.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ringstedt, J. E. Braisted, K. Brose, T. Kidd, C. Goodman, M. Tessier-Lavigne, and D. D. M. O'Leary
Slit Inhibition of Retinal Axon Growth and Its Role in Retinal Axon Pathfinding and Innervation Patterns in the Diencephalon
J. Neurosci.,
July 1, 2000;
20(13):
4983 - 4991.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Skaliora, R. Adams, and C. Blakemore
Morphology and Growth Patterns of Developing Thalamocortical Axons
J. Neurosci.,
May 15, 2000;
20(10):
3650 - 3662.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Chung, J. Taylor, D. Shum, and S. Chan
Axon routing at the optic chiasm after enzymatic removal of chondroitin sulfate in mouse embryos
Development,
January 6, 2000;
127(12):
2673 - 2683.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G Alvarez-Bolado, X Zhou, A. Voss, T Thomas, and P Gruss
Winged helix transcription factor Foxb1 is essential for access of mammillothalamic axons to the thalamus
Development,
January 3, 2000;
127(5):
1029 - 1038.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Bertuzzi, R. Hindges, S. H. Mui, D. D.M. O'Leary, and G. Lemke
The homeodomain protein Vax1 is required for axon guidance and major tract formation in the developing forebrain
Genes & Dev.,
December 1, 1999;
13(23):
3092 - 3105.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. S. Deiner and D. W. Sretavan
Altered Midline Axon Pathways and Ectopic Neurons in the Developing Hypothalamus of Netrin-1- and DCC-Deficient Mice
J. Neurosci.,
November 15, 1999;
19(22):
9900 - 9912.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. W. Sretavan and K. Kruger
Randomized Retinal Ganglion Cell Axon Routing at the Optic Chiasm of GAP-43-Deficient Mice: Association with Midline Recrossing and Lack of Normal Ipsilateral Axon Turning
J. Neurosci.,
December 15, 1998;
18(24):
10502 - 10513.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kruger, A. S. Tam, C. Lu, and D. W. Sretavan
Retinal Ganglion Cell Axon Progression from the Optic Chiasm to Initiate Optic Tract Development Requires Cell Autonomous Function of GAP-43
J. Neurosci.,
August 1, 1998;
18(15):
5692 - 5705.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. W. Davenport, E. Thies, R. Zhou, and P. G. Nelson
Cellular Localization of Ephrin-A2, Ephrin-A5, and Other Functional Guidance Cues Underlies Retinotopic Development across Species
J. Neurosci.,
February 1, 1998;
18(3):
975 - 986.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Mason and L.-C. Wang
Growth Cone Form Is Behavior-Specific and, Consequently, Position-Specific along the Retinal Axon Pathway
J. Neurosci.,
February 1, 1997;
17(3):
1086 - 1100.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R Macdonald, J Scholes, U Strahle, C Brennan, N Holder, M Brand, and S. Wilson
The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain
Development,
January 6, 1997;
124(12):
2397 - 2408.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M Torres, E Gomez-Pardo, and P Gruss
Pax2 contributes to inner ear patterning and optic nerve trajectory
Development,
January 11, 1996;
122(11):
3381 - 3391.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. Marcus, L. Wang, and C. Mason
Retinal axon divergence in the optic chiasm: midline cells are unaffected by the albino mutation
Development,
January 3, 1996;
122(3):
859 - 868.
[Abstract]
[PDF]
|
|
|
|
|
