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Journal of Neuroscience, Vol 15, 6542-6551, Copyright © 1995 by Society for Neuroscience

ARTICLE

Expression of EPSP/spike potentiation following low frequency and tetanic stimulation in the CA1 area of the rat hippocampus

C Bernard and HV Wheal
Department of Physiology and Pharmacology, University of Southampton, United Kingdom.

Low frequency stimulation (LFS, 1 Hz for 15 min) has been shown to produce an NMDA receptor dependent homosynaptic long-term depression (LTD) of synaptic potentials in the CA1 area of the rat hippocampus. Here we describe experiments aimed at characterizing EPSP/spike (E/S) coupling associated with this form of LTD. Our data show that following LFS neurons have a higher probability of synchronous discharge in response to a population EPSP of fixed slope (E/S potentiation). This E/S potentiation was not significantly enhanced by a tetanic stimulation. When the protocol was reversed, that is, starting with a tetanic stimulus, E/S potentiation was observed which was unaffected by a subsequent LFS. Saturating these synaptic responses to either a maximal or a minimal value produced similar effects on E/S coupling. E/S depression was never encountered. Finally, we found that the expression of E/S potentiation did not require the activation of NMDA receptors. These data suggest that at the level of a local neuronal network in the CA1 area, LFS is not a very powerful tool since the synaptic depression is associated with a potentiation of the population response of these neurons. Furthermore, the expression of E/S dissociation seems different from that of homosynaptic long-term potentiation and LTD.

This article has been cited by other articles:

				G. Daoudal, Y. Hanada, and D. Debanne Bidirectional plasticity of excitatory postsynaptic potential (EPSP)-spike coupling in CA1 hippocampal pyramidal neurons PNAS, October 29, 2002; 99(22): 14512 - 14517. [Abstract] [Full Text] [PDF]

				A. Kimura and C. Pavlides Long-Term Potentiation/Depotentiation Are Accompanied by Complex Changes in Spontaneous Unit Activity in the Hippocampus J Neurophysiol, October 1, 2000; 84(4): 1894 - 1906. [Abstract] [Full Text] [PDF]

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