Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):
Year:		Vol:		Page:

HOME | SEARCH | ARCHIVE | SUBSCRIBE | CONTACT | HELP

This Article

Full Text (PDF)

Submit an eLetter

Alert me when this article is cited

Alert me when eLetters are posted

Alert me if a correction is posted

Citation Map

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Mackie, K.

Articles by Mitchell, R.

Search for Related Content

PubMed

PubMed Citation

Articles by Mackie, K.

Articles by Mitchell, R.

Previous Article | Next Article

Journal of Neuroscience, Vol 15, 6552-6561, Copyright © 1995 by Society for Neuroscience

ARTICLE

Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor

K Mackie, Y Lai, R Westenbroek and R Mitchell
Department of Anesthesiology, University of Washington, Seattle 98195, USA.
Rat brain cannabinoid receptor (CB-1) was stably transfected into the murine tumor line AtT-20 to study its coupling to inwardly rectifying potassium currents (Kir) and high voltage-activated calcium currents (ICa). In cells expressing CB-1 ("A-2" cells), cannabinoid agonist potently and stereospecifically activated Kir via a pertussis toxin- sensitive G protein. ICa in A-2 cells was sensitive to dihydropyridines and omega CTX MVIIC, less so to omega CgTX GVIA and insensitive to omega Aga IVa. In CB-1 expressing cells, cannabinoid agonist inhibited only the omega CTX MVIIC-sensitive component of ICa. Inhibition of Q- type ICa was voltage dependent and PTX sensitive, thus similar in character to the well-studied modulation of N-type ICa. An endogenous cannabinoid, anandamide, activated Kir and inhibited ICa as efficaciously as potent cannabinoid agonist. Immunocytochemical studies with antibodies specific for class A, B, C, D, and E voltage-dependent calcium channel alpha 1 subunits revealed that AtT-20 cells express each of these major classes of alpha 1 subunit.

This article has been cited by other articles:

S. C. Azad, J. Kurz, G. Marsicano, B. Lutz, W. Zieglgansberger, and G. Rammes
Activation of CB1 specifically located on GABAergic interneurons inhibits LTD in the lateral amygdala
Learn. Mem., March 5, 2008; 15(3): 143 - 152.
[Abstract] [Full Text] [PDF]

J. E. Lauckner, J. B. Jensen, H.-Y. Chen, H.-C. Lu, B. Hille, and K. Mackie
GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current
PNAS, February 19, 2008; 105(7): 2699 - 2704.
[Abstract] [Full Text] [PDF]

E. Sanchez-Pastor, X. Trujillo, M. Huerta, and F. Andrade
Effects of Cannabinoids on Synaptic Transmission in the Frog Neuromuscular Junction
J. Pharmacol. Exp. Ther., May 1, 2007; 321(2): 439 - 445.
[Abstract] [Full Text] [PDF]

S. Akerman, P. R. Holland, and P. J. Goadsby
Cannabinoid (CB1) Receptor Activation Inhibits Trigeminovascular Neurons
J. Pharmacol. Exp. Ther., January 1, 2007; 320(1): 64 - 71.
[Abstract] [Full Text] [PDF]

P. Pacher, S. Batkai, and G. Kunos
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pharmacol. Rev., September 1, 2006; 58(3): 389 - 462.
[Abstract] [Full Text] [PDF]

L. J. Sim-Selley, N. S. Schechter, W. K. Rorrer, G. D. Dalton, J. Hernandez, B. R. Martin, and D. E. Selley
Prolonged Recovery Rate of CB1 Receptor Adaptation after Cessation of Long-Term Cannabinoid Administration
Mol. Pharmacol., September 1, 2006; 70(3): 986 - 996.
[Abstract] [Full Text] [PDF]

H. Wang, S. K. Dey, and M. Maccarrone
Jekyll and Hyde: Two Faces of Cannabinoid Signaling in Male and Female Fertility
Endocr. Rev., August 1, 2006; 27(5): 427 - 448.
[Abstract] [Full Text] [PDF]

T. L Burns and J. R Ineck
Cannabinoid Analgesia as a Potential New Therapeutic Option in the Treatment of Chronic Pain
Ann. Pharmacother., February 1, 2006; 40(2): 251 - 260.
[Abstract] [Full Text] [PDF]

J. E. Lauckner, B. Hille, and K. Mackie
The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins
PNAS, December 27, 2005; 102(52): 19144 - 19149.
[Abstract] [Full Text] [PDF]

S. L. Tang, V. Tran, and E. J. Wagner
Sex Differences in the Cannabinoid Modulation of an A-Type K+ Current in Neurons of the Mammalian Hypothalamus
J Neurophysiol, October 1, 2005; 94(4): 2983 - 2986.
[Abstract] [Full Text] [PDF]

F. RODRIGUEZ de FONSECA, I. DEL ARCO, F. J. BERMUDEZ-SILVA, A. BILBAO, A. CIPPITELLI, and M. NAVARRO
THE ENDOCANNABINOID SYSTEM: PHYSIOLOGY AND PHARMACOLOGY
Alcohol Alcohol., January 1, 2005; 40(1): 2 - 14.
[Abstract] [Full Text] [PDF]

B. S. BASAVARAJAPPA and B. L. HUNGUND
ROLE OF THE ENDOCANNABINOID SYSTEM IN THE DEVELOPMENT OF TOLERANCE TO ALCOHOL
Alcohol Alcohol., January 1, 2005; 40(1): 15 - 24.
[Abstract] [Full Text] [PDF]

M. Hirasawa, Y. Schwab, S. Natah, C. J. Hillard, K. Mackie, K. A. Sharkey, and Q. J. Pittman
Dendritically released transmitters cooperate via autocrine and retrograde actions to inhibit afferent excitation in rat brain
J. Physiol., September 1, 2004; 559(2): 611 - 624.
[Abstract] [Full Text] [PDF]

H. Daniel, A. Rancillac, and F. Crepel
Mechanisms underlying cannabinoid inhibition of presynaptic Ca2+ influx at parallel fibre synapses of the rat cerebellum
J. Physiol., May 15, 2004; 557(1): 159 - 174.
[Abstract] [Full Text] [PDF]

T. W. Klein, C. Newton, K. Larsen, L. Lu, I. Perkins, L. Nong, and H. Friedman
The cannabinoid system and immune modulation
J. Leukoc. Biol., October 1, 2003; 74(4): 486 - 496.
[Abstract] [Full Text] [PDF]

M. A. Diana and A. Marty
Characterization of Depolarization-Induced Suppression of Inhibition Using Paired Interneuron-Purkinje Cell Recordings
J. Neurosci., July 2, 2003; 23(13): 5906 - 5918.
[Abstract] [Full Text] [PDF]

T. F. FREUND, I. KATONA, and D. PIOMELLI
Role of Endogenous Cannabinoids in Synaptic Signaling
Physiol Rev, July 1, 2003; 83(3): 1017 - 1066.
[Abstract] [Full Text] [PDF]

S. L. Borgland, M. Connor, P. B. Osborne, J. B. Furness, and M. J. Christie
Opioid Agonists Have Different Efficacy Profiles for G Protein Activation, Rapid Desensitization, and Endocytosis of Mu-opioid Receptors
J. Biol. Chem., May 23, 2003; 278(21): 18776 - 18784.
[Abstract] [Full Text] [PDF]

A. Straiker and J. M. Sullivan
Cannabinoid Receptor Activation Differentially Modulates Ion Channels in Photoreceptors of the Tiger Salamander
J Neurophysiol, May 1, 2003; 89(5): 2647 - 2654.
[Abstract] [Full Text] [PDF]

S. Tripathy, K. Kleppinger-Sparace, R. A. Dixon, and K. D. Chapman
N-Acylethanolamine Signaling in Tobacco Is Mediated by a Membrane-Associated, High-Affinity Binding Protein
Plant Physiology, April 1, 2003; 131(4): 1781 - 1791.
[Abstract] [Full Text] [PDF]

S. C. Azad, M. Eder, G. Marsicano, B. Lutz, W. Zieglgansberger, and G. Rammes
Activation of the Cannabinoid Receptor Type 1 Decreases Glutamatergic and GABAergic Synaptic Transmission in the Lateral Amygdala of the Mouse
Learn. Mem., March 1, 2003; 10(2): 116 - 128.
[Abstract] [Full Text] [PDF]

D. P. Hurst, D. L. Lynch, J. Barnett-Norris, S. M. Hyatt, H. H. Seltzman, M. Zhong, Z.-H. Song, J. Nie, D. Lewis, and P. H. Reggio
N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A) Interaction with LYS 3.28(192) Is Crucial for Its Inverse Agonism at the Cannabinoid CB1 Receptor
Mol. Pharmacol., December 1, 2002; 62(6): 1274 - 1287.
[Abstract] [Full Text] [PDF]

L. J. Sim-Selley and B. R. Martin
Effect of Chronic Administration of R-(+)-[2,3-Dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone Mesylate (WIN55,212-2) or Delta 9-Tetrahydrocannabinol on Cannabinoid Receptor Adaptation in Mice
J. Pharmacol. Exp. Ther., October 1, 2002; 303(1): 36 - 44.
[Abstract] [Full Text] [PDF]

B. R. Martin
Identification of the Endogenous Cannabinoid System through Integrative Pharmacological Approaches
J. Pharmacol. Exp. Ther., June 1, 2002; 301(3): 790 - 796.
[Abstract] [Full Text] [PDF]

A. C. Howlett, F. Barth, T. I. Bonner, G. Cabral, P. Casellas, W. A. Devane, C. C. Felder, M. Herkenham, K. Mackie, B. R. Martin, et al.
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Pharmacol. Rev., June 1, 2002; 54(2): 161 - 202.
[Abstract] [Full Text] [PDF]

T. Ohno-Shosaku, H. Tsubokawa, I. Mizushima, N. Yoneda, A. Zimmer, and M. Kano
Presynaptic Cannabinoid Sensitivity Is a Major Determinant of Depolarization-Induced Retrograde Suppression at Hippocampal Synapses
J. Neurosci., May 15, 2002; 22(10): 3864 - 3872.
[Abstract] [Full Text] [PDF]

M. A. Diana, C. Levenes, K. Mackie, and A. Marty
Short-Term Retrograde Inhibition of GABAergic Synaptic Currents in Rat Purkinje Cells Is Mediated by Endogenous Cannabinoids
J. Neurosci., January 1, 2002; 22(1): 200 - 208.
[Abstract] [Full Text] [PDF]

J. Nie and D. L. Lewis
Structural Domains of the CB1 Cannabinoid Receptor That Contribute to Constitutive Activity and G-Protein Sequestration
J. Neurosci., November 15, 2001; 21(22): 8758 - 8764.
[Abstract] [Full Text] [PDF]

V. Morisset and L. Urban
Cannabinoid-Induced Presynaptic Inhibition of Glutamatergic EPSCs in Substantia Gelatinosa Neurons of the Rat Spinal Cord
J Neurophysiol, July 1, 2001; 86(1): 40 - 48.
[Abstract] [Full Text] [PDF]

C. S. Breivogel, G. Griffin, V. Di Marzo, and B. R. Martin
Evidence for a New G Protein-Coupled Cannabinoid Receptor in Mouse Brain
Mol. Pharmacol., July 1, 2001; 60(1): 155 - 163.
[Abstract] [Full Text]

J. J. Rodriguez, K. Mackie, and V. M. Pickel
Ultrastructural Localization of the CB1 Cannabinoid Receptor in {micro}-Opioid Receptor Patches of the Rat Caudate Putamen Nucleus
J. Neurosci., February 1, 2001; 21(3): 823 - 833.
[Abstract] [Full Text] [PDF]

A. F. Hoffman and C. R. Lupica
Direct Actions of Cannabinoids on Synaptic Transmission in the Nucleus Accumbens: A Comparison With Opioids
J Neurophysiol, January 1, 2001; 85(1): 72 - 83.
[Abstract] [Full Text] [PDF]

D. Robbe, G. Alonso, F. Duchamp, J. Bockaert, and O. J. Manzoni
Localization and Mechanisms of Action of Cannabinoid Receptors at the Glutamatergic Synapses of the Mouse Nucleus Accumbens
J. Neurosci., January 1, 2001; 21(1): 109 - 116.
[Abstract] [Full Text] [PDF]

C. S. Breivogel and S. R. Childers
Cannabinoid Agonist Signal Transduction in Rat Brain: Comparison of Cannabinoid Agonists in Receptor Binding, G-Protein Activation, and Adenylyl Cyclase Inhibition
J. Pharmacol. Exp. Ther., October 1, 2000; 295(1): 328 - 336.
[Abstract] [Full Text]

N. Auclair, S. Otani, P. Soubrie, and F. Crepel
Cannabinoids Modulate Synaptic Strength and Plasticity at Glutamatergic Synapses of Rat Prefrontal Cortex Pyramidal Neurons
J Neurophysiol, June 1, 2000; 83(6): 3287 - 3293.
[Abstract] [Full Text] [PDF]

B. Y. Ho, A. Stadnicka, P. L. Prather, A. R. Buckley, L. L. Current, Z. J. Bosnjak, and W.-M. Kwok
Cannabinoid CB1 Receptor-Mediated Inhibition of Prolactin Release and Signaling Mechanisms in GH4C1 Cells
Endocrinology, May 1, 2000; 141(5): 1675 - 1685.
[Abstract] [Full Text] [PDF]

J. M. Sullivan
Cellular and Molecular Mechanisms Underlying Learning and Memory Impairments Produced by Cannabinoids
Learn. Mem., May 1, 2000; 7(3): 132 - 139.
[Abstract] [Full Text]

P. L. Prather, N. A. Martin, C. S. Breivogel, and S. R. Childers
Activation of Cannabinoid Receptors in Rat Brain by WIN 55212-2 Produces Coupling to Multiple G Protein alpha -Subunits with Different Potencies
Mol. Pharmacol., May 1, 2000; 57(5): 1000 - 1010.
[Abstract] [Full Text]

A. F. Hoffman and C. R. Lupica
Mechanisms of Cannabinoid Inhibition of GABAA Synaptic Transmission in the Hippocampus
J. Neurosci., April 1, 2000; 20(7): 2470 - 2479.
[Abstract] [Full Text] [PDF]

M.-H. Rhee, I. Nevo, T. Avidor-Reiss, R. Levy, and Z. Vogel
Differential Superactivation of Adenylyl Cyclase Isozymes after Chronic Activation of the CB1 Cannabinoid Receptor
Mol. Pharmacol., April 1, 2000; 57(4): 746 - 752.
[Abstract] [Full Text]

K. A. Takahashi and D. J. Linden
Cannabinoid Receptor Modulation of Synapses Received by Cerebellar Purkinje Cells
J Neurophysiol, March 1, 2000; 83(3): 1167 - 1180.
[Abstract] [Full Text] [PDF]

B. L. Hungund and B. S. Basavarajappa
ARE ANANDAMIDE AND CANNABINOID RECEPTORS INVOLVED IN ETHANOL TOLERANCE? A REVIEW OF THE EVIDENCE
Alcohol Alcohol., March 1, 2000; 35(2): 126 - 133.
[Abstract] [Full Text] [PDF]

C. W. Vaughan, M. Connor, E. E. Bagley, and M. J. Christie
Actions of Cannabinoids on Membrane Properties and Synaptic Transmission in Rat Periaqueductal Gray Neurons In Vitro
Mol. Pharmacol., February 1, 2000; 57(2): 288 - 295.
[Abstract] [Full Text]

P. Schweitzer
Cannabinoids Decrease the K+ M-Current in Hippocampal CA1 Neurons
J. Neurosci., January 1, 2000; 20(1): 51 - 58.
[Abstract] [Full Text] [PDF]

A. Straiker, N. Stella, D. Piomelli, K. Mackie, H. J. Karten, and G. Maguire
Cannabinoid CB1 receptors and ligands in vertebrate retina: Localization and function of an endogenous signaling system
PNAS, December 7, 1999; 96(25): 14565 - 14570.
[Abstract] [Full Text] [PDF]

M. Glass and J. K. Northup
Agonist Selective Regulation of G Proteins by Cannabinoid CB1 and CB2 Receptors
Mol. Pharmacol., December 1, 1999; 56(6): 1362 - 1369.
[Abstract] [Full Text]

S. D. McAllister, G. Griffin, L. S. Satin, and M. E. Abood
Cannabinoid Receptors Can Activate and Inhibit G Protein-Coupled Inwardly Rectifying Potassium Channels in a Xenopus Oocyte Expression System
J. Pharmacol. Exp. Ther., November 1, 1999; 291(2): 618 - 626.
[Abstract] [Full Text]

C.-n. Chin, J. W. Murphy, J. W. Huffman, and D. A. Kendall
The Third Transmembrane Helix of the Cannabinoid Receptor Plays a Role in the Selectivity of Aminoalkylindoles for CB2, Peripheral Cannabinoid Receptor
J. Pharmacol. Exp. Ther., November 1, 1999; 291(2): 837 - 844.
[Abstract] [Full Text]

C. Vasquez and D. L. Lewis
The CB1 Cannabinoid Receptor Can Sequester G-Proteins, Making Them Unavailable to Couple to Other Receptors
J. Neurosci., November 1, 1999; 19(21): 9271 - 9280.
[Abstract] [Full Text] [PDF]

J. G. Netzeband, S. M. Conroy, K. L. Parsons, and D. L. Gruol
Cannabinoids Enhance NMDA-Elicited Ca2+ Signals in Cerebellar Granule Neurons in Culture
J. Neurosci., October 15, 1999; 19(20): 8765 - 8777.
[Abstract] [Full Text] [PDF]

J. M. Sullivan
Mechanisms of Cannabinoid-Receptor-Mediated Inhibition of Synaptic Transmission in Cultured Hippocampal Pyramidal Neurons
J Neurophysiol, September 1, 1999; 82(3): 1286 - 1294.
[Abstract] [Full Text] [PDF]

A. J. Straiker, G. Maguire, K. Mackie, and J. Lindsey
Localization of Cannabinoid CB1 Receptors in the Human Anterior Eye and Retina
Invest. Ophthalmol. Vis. Sci., September 1, 1999; 40(10): 2442 - 2448.
[Abstract] [Full Text] [PDF]

J. P. Roche, S. Bounds, S. Brown, and K. Mackie
A Mutation in the Second Transmembrane Region of the CB1 Receptor Selectively Disrupts G Protein Signaling and Prevents Receptor Internalization
Mol. Pharmacol., September 1, 1999; 56(3): 611 - 618.
[Abstract] [Full Text]

D. L. Misner and J. M. Sullivan
Mechanism of Cannabinoid Effects on Long-Term Potentiation and Depression in Hippocampal CA1 Neurons
J. Neurosci., August 15, 1999; 19(16): 6795 - 6805.
[Abstract] [Full Text] [PDF]

A. Meir, S. Ginsburg, A. Butkevich, S. G. Kachalsky, I. Kaiserman, R. Ahdut, S. Demirgoren, and R. Rahamimoff
Ion Channels in Presynaptic Nerve Terminals and Control of Transmitter Release
Physiol Rev, July 1, 1999; 79(3): 1019 - 1088.
[Abstract] [Full Text] [PDF]

I. Katona, B. Sperlagh, A. Sik, A. Kafalvi, E. S. Vizi, K. Mackie, and T. F. Freund
Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons
J. Neurosci., June 1, 1999; 19(11): 4544 - 4558.
[Abstract] [Full Text] [PDF]

D. Gebremedhin, A. R. Lange, W. B. Campbell, C. J. Hillard, and D. R. Harder
Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current
Am J Physiol Heart Circ Physiol, June 1, 1999; 276(6): H2085 - H2093.
[Abstract] [Full Text] [PDF]

W. Jin, S. Brown, J. P. Roche, C. Hsieh, J. P. Celver, A. Kovoor, C. Chavkin, and K. Mackie
Distinct Domains of the CB1 Cannabinoid Receptor Mediate Desensitization and Internalization
J. Neurosci., May 15, 1999; 19(10): 3773 - 3780.
[Abstract] [Full Text] [PDF]

P. F Smith and C. L Darlington
Recent developments in drug therapy for multiple sclerosis
Multiple Sclerosis, April 1, 1999; 5(2): 110 - 120.
[Abstract] [PDF]

E. V. Kuzhikandathil and G. S. Oxford
Activation of Human D3 Dopamine Receptor Inhibits P/Q-Type Calcium Channels and Secretory Activity in AtT-20 Cells
J. Neurosci., March 1, 1999; 19(5): 1698 - 1707.
[Abstract] [Full Text] [PDF]