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Journal of Neuroscience, Vol 15, 6868-6878, Copyright © 1995 by Society for Neuroscience
Morphological evidence for the sprouting of inhibitory commissural fibers in response to the lesion of the excitatory entorhinal input to the rat dentate gyrus
T Deller, M Frotscher and R Nitsch
Institute of Anatomy, University of Freiburg, Germany.
Recently a commissural fiber projection that terminates in the outer
molecular layer of the fascia dentata was described in normal rats (Deller
et al., 1995). In the present article, Phaseolus vulgaris leucoagglutinin
(PHAL) tracing was used to analyze the contribution of this previously
unknown projection to the commissural sprouting response after entorhinal
cortex lesion. Rats 4-8 weeks after unilateral entorhinal lesion received a
single PHAL deposit into the hilus of the fascia dentata contralateral to
the lesion side. Unlesioned control animals received a similar PHAL
deposit. The degree of axonal arborization and the bouton density per axon
length were determined for individual PHAL-labeled commissural axons to the
outer molecular layer of the dentate gyrus. A significant increase in both
parameters was observed in the lesioned group. The PHAL-labeled commissural
fibers established symmetric synapses in the denervated outer molecular
layer. Postembedding immunocytochemistry indicated that some of these
sprouting commissural fibers are GABAergic. Our findings provide
morphological evidence for lamina-specific sprouting of an inhibitory
commissural projection that normally terminates in the outer molecular
layer. This suggests that inhibitory fibers participate in the replacement
of the excitatory perforant pathway after entorhinal lesion.
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