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Journal of Neuroscience, Vol 15, 6919-6925, Copyright © 1995 by Society for Neuroscience
Repeated exposure to one song leads to a rapid and persistent decline in an immediate early gene's response to that song in zebra finch telencephalon
C Mello, F Nottebohm and D Clayton
Rockefeller University, Laboratory of Animal Behavior, New York, New York 10021, USA.
Conspecific song induces a prompt increase in the expression of the zenk
gene in the caudo-medial neostriatum (NCM), a part of the auditory
telencephalon of songbirds. To test the hypothesis that zenk gene induction
in NCM is related to the acquisition of new song-related memories, we
presented adult male zebra finches with repeated playbacks of one song. In
response, zenk mRNA levels in NCM increased for the first 30 min, but then
declined back to baseline levels despite continued stimulation with the
same song. When a novel song was then introduced, however, a full zenk
response was triggered once again. Even when a full day had passed between
the last exposure to a song and the testing period, the song that had been
rendered "familiar" by repetition caused no zenk response, whereas a novel
song caused a full response. Quantitative analysis indicates that
individual cells in NCM must have undergone a selective loss in their zenk
responsiveness to the repeated song, while still maintaining their ability
to respond to the novel song. These results support the hypothesis that the
induction of zenk is related to the formation of long-term memories.
Analysis of the stimulus-specific modulation of zenk responses, coupled
with appropriate behavioral assays, should provide insight into neural
mechanisms responsible for the discrimination and storage of complex
perceptual information.
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