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Journal of Neuroscience, Vol 15, 7046-7061, Copyright © 1995 by Society for Neuroscience
Differential expression of AMPA receptor subunits in NOS-positive neurons of cortex, striatum, and hippocampus
MV Catania, TR Tolle and H Monyer
Zentrum fur Molekulare Biologie (ZMBH), Universitat Heidelberg, Germany.
AMPA receptor (AMPAR) subunits expression was studied in nitric oxide
synthase (NOS)-positive neurons of the adult rat cortex, striatum, and
hippocampus, by a double-labeling approach, combining nonradioactive in
situ hybridization and immunocytochemistry. The majority of cortical and
hippocampal NOS-immunopositive neurons were characterized by a predominant
expression of GluR-A and -D mRNA and low or undetectable expression of
GluR-B and -C mRNA. In the striatum, the expression profile of AMPAR
subunits in NOS-positive neurons differed from that in the other two
regions. This is reflected in the overall low expression of all AMPA
receptor subunits and the paucity of GluR-D subunit expression that
contrasts with the high expression of this subunit in NOS-positive cells in
the hippocampus. Double-labeling experiments revealed a substantial
correspondence between mRNA and protein levels of AMPAR subunits. Further
evidence for the regional diversity of NOS- positive neurons is derived
from the expression analysis of glutamate decarboxylase (GAD)-65 and -67
mRNAs. NOS-positive neurons expressed high levels of GAD-65, but not -67 in
the cortex, high levels of both forms in the hippocampus, and low or
undetectable levels of both mRNAs in the striatum. Despite of these
differences, NOS-positive neurons share the common feature of low GluR-B
subunit expression, suggesting the presence of AMPAR channels with high
Ca2+ permeability, regardless of the regional location. The relative
resistance of NOS-positive interneurons in neurodegenerative diseases
suggests that glutamate receptor-mediated Ca2+ influx alone does not
suffice to explain neuronal vulnerability, and additional factors have thus
to be considered.
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