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Journal of Neuroscience, Vol 15, 7270-7281, Copyright © 1995 by Society for Neuroscience
A comparison of the effects of medial prefrontal, cingulate cortex, and cingulum bundle lesions on tests of spatial memory: evidence of a double dissociation between frontal and cingulum bundle contributions
JP Aggleton, N Neave, S Nagle and A Sahgal
Department of Psychology, University of Durham, United Kingdom.
Rats were trained on an automated delayed nonmatching-to-position (DNMP)
task. They then received cytotoxic lesions in either the medial prefrontal
cortex (n = 13) or the cingulate and retrosplenial cortices (n = 8), or
radiofrequency lesions in either the fornix (n = 6) or the cingulum bundle
(n = 8). Twelve animals served as surgical controls. Only the fornical and
medial prefrontal lesions disrupted DNMP performance, both groups showing a
loss of accuracy and an increase in bias. The rats were then trained on a
lever discrimination and reversal task, the medial prefrontal and fornical
groups showing evidence of an increase in bias when compared with the
cingulate cortex group. Finally, the rats were trained on a forced
alternation task in a T- maze. Marked deficits were observed in the fornix
and cingulum bundle groups, but the medial prefrontal and cingulate groups
were unimpaired. The double dissociation between the effects of the
prefrontal and cingulum bundle lesions highlights the very different nature
of the two spatial tasks (DNMP and T-maze alternation), even though both
involved a nonmatching rule. These findings may reflect the involvement of
divergent outputs from the fornix-anterior thalamic pathway. One
possibility is that anterior thalamic projections to the medial prefrontal
cortex are concerned with processing egocentric information, while anterior
thalamic projections to temporal regions via the cingulum bundle are
concerned with allocentric information. The results also indicate that the
effects of conventional lesions in the cingulate cortex and medial
prefrontal cortex may be compromised by additional damage to the cingulum
bundle.
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