QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schmidt, E. D. Articles by Tilders, F. J. Search for Related Content PubMed PubMed Citation Articles by Schmidt, E. D. Articles by Tilders, F. J.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 15, 7417-7426, Copyright © 1995 by Society for Neuroscience

ARTICLE

Interleukin-1-induced long-lasting changes in hypothalamic corticotropin-releasing hormone (CRH)--neurons and hyperresponsiveness of the hypothalamus-pituitary-adrenal axis

ED Schmidt, AW Janszen, FG Wouterlood and FJ Tilders
Graduate School Neurosciences Amsterdam, Vrije Universiteit, Faculty of Medicine, Department of Pharmacology, The Netherlands.

Hypothalamic CRH neurons that control ACTH secretion from the pituitary gland have secretory terminals in the external zone of the median eminence (ZEME). These neurons can coproduce vasopressin (AVP), a neuropeptide that potentiates the ACTH releasing effects of CRH. Recently, we found increased AVP production in adult rats weeks after single exposure to a stressor, which may play a role in event-induced stress disorders. Here, we describe the long-term changes in the HPA axis of adult male rats following a single exposure to a stressor, the cytokine interleukin-1 beta (IL-1 beta). The effects on storage and release of AVP and CRH were established by quantitative immunocytochemistry, the effects on ACTH and corticosterone responses by radioimmunoassay. Single administration of IL-1 beta (5 micrograms/kg i.p.) induces a delayed (at least 4 d) and a long-lasting (at least 3 weeks) increase of vasopressin (AVP) stores in CRH terminals of the ZEME without affecting the CRH stores, and a marked increase of the fraction of CRH terminals that costore AVP. Eleven days after IL-1 beta administration, a second IL-1 beta challenge causes a marked depletion of the AVP stores in the ZEME within 2 hr, which is not seen in rats treated with vehicle 11 d earlier. This is accompanied by twofold higher ACTH and corticosterone responses, as compared to those in vehicle pretreated rats. IL-1 beta-pretreated rats also showed increased ACTH and corticosterone responses to electric footshocks. We conclude that transient activation of the HPA axis by a single administration of IL-1 beta induces a delayed and long-lasting hyperproduction, hyperstorage, and hypersecretion of AVP from hypothalamic CRH neurons that results in hyperresponsiveness of the HPA axis to subsequent stimuli.

This article has been cited by other articles:

				S. Ma, M. J. Shipston, D. Morilak, and J. A. Russell Reduced Hypothalamic Vasopressin Secretion Underlies Attenuated Adrenocorticotropin Stress Responses in Pregnant Rats Endocrinology, March 1, 2005; 146(3): 1626 - 1637. [Abstract] [Full Text] [PDF]

				J. D. Johnson, K. A. O'Connor, M. K. Hansen, L. R. Watkins, and S. F. Maier Effects of prior stress on LPS-induced cytokine and sickness responses Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R422 - R432. [Abstract] [Full Text] [PDF]

				A. Valles, O. Marti, A. Garcia, and A. Armario Single exposure to stressors causes long-lasting, stress-dependent reduction of food intake in rats Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2000; 279(3): R1138 - R1144. [Abstract] [Full Text] [PDF]

				S. Hayley, K. Brebner, S. Lacosta, Z. Merali, and H. Anisman Sensitization to the Effects of Tumor Necrosis Factor-alpha : Neuroendocrine, Central Monoamine, and Behavioral Variations J. Neurosci., July 1, 1999; 19(13): 5654 - 5665. [Abstract] [Full Text] [PDF]

				I. Dijkstra, F. J. H. Tilders, G. Aguilera, A. Kiss, C. Rabadan-Diehl, N. Barden, S. Karanth, F. Holsboer, and J. M. H. M. Reul Reduced Activity of Hypothalamic Corticotropin-Releasing Hormone Neurons in Transgenic Mice with Impaired Glucocorticoid Receptor Function J. Neurosci., May 15, 1998; 18(10): 3909 - 3918. [Abstract] [Full Text] [PDF]

				J. Raber, R. D. O'Shea, F. E. Bloom, and I. L. Campbell Modulation of Hypothalamic-Pituitary-Adrenal Function by Transgenic Expression of Interleukin-6 in the CNS of Mice J. Neurosci., December 15, 1997; 17(24): 9473 - 9480. [Abstract] [Full Text] [PDF]

				S. Lee and C. Rivier An Initial, Three-Day-Long Treatment with Alcohol Induces a Long-Lasting Phenomenon of Selective Tolerance in the Activity of the Rat Hypothalamic-Pituitary-Adrenal Axis J. Neurosci., November 15, 1997; 17(22): 8856 - 8866. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help