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Journal of Neuroscience, Vol 15, 8039-8052, Copyright © 1995 by Society for Neuroscience
Synchronized oscillations in hippocampal CA3 neurons induced by metabotropic glutamate receptor activation
GW Taylor, LR Merlin and RK Wong
Department of Pharmacology, State University of New York Health Science Center at Brooklyn 11203, USA.
The metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-
1,3 dicarboxylic acid (ACPD) at concentrations above 60 microM produced
stereotypic oscillatory activity in CA3 pyramidal cells of rat hippocampal
slices. This oscillatory activity consisted of trains of depolarizations
with overriding action potentials. On average, individual trains lasted 7
sec and recurred at intervals of 24 sec. During each train, the constituent
depolarizations achieved a maximum frequency of 27 Hz, then slowed to 8 Hz
toward the end of the train. Extracellular and dual intracellular
recordings suggested that this ACPD-induced oscillatory activity occurred
synchronously in the CA3 population. The oscillations persisted in the
presence of GABAA, GABAB, and NMDA receptor antagonists. In contrast, the
oscillations were blocked by the AMPA/kainate receptor antagonist
6-cyano-7- nitroquinoxaline-2,3-dione (CNQX; 10-30 microM). Likewise, the
oscillations were blocked by the metabotropic glutamate receptor
antagonists (+)-alpha-methyl-4-carboxyphenylglycine [(+)-MCPG; 1 mM],
(S)-4-carboxy-3-hydroxyphenylglycine [(S)-4C3HPG; 1mM] and (S)-4-
carboxyphenylglycine [(S)-4CPG; 1 mM]. The results suggest that activation
of metabotropic glutamate receptors can result in a permissive state that
allows AMPA/kainate receptor-mediated conductances to mediate synchronized
activity among hippocampal CA3 neurons.
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