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Journal of Neuroscience, Vol 15, 1012-1024, Copyright © 1995 by Society for Neuroscience
Oligodendrocytes originate in a restricted zone of the embryonic ventral neural tube defined by DM-20 mRNA expression
S Timsit, S Martinez, B Allinquant, F Peyron, L Puelles and B Zalc
Laboratoire de Neurobiologie Cellulaire, Moleculaire et Clinique, INSERM U-134, Hopital de la Salpetriere, Universite Pierre et Marie Curie, Paris, France.
Products of the PLP gene, proteolipid protein and its isoform DM-20, are
the most abundant proteins in CNS myelin, and are markers of the
oligodendrocyte, the myelin-forming cell in the CNS. The DM-20 transcript
has previously been reported to be expressed in newborn oligodendrocyte
progenitor cells and during embryonic development. We have therefore used a
DM-20 cRNA probe to follow, by in situ hybridization, the oligodendrocyte
lineage during embryonic development. DM-20-expressing cells were first
detected at E9.5 in the ventricular germinal layer of the laterobasal plate
of the diencephalon. At E14.5, DM-20+ cells had largely disappeared from
the diencephalic ventricular germinal layer and had colonized the ventral
mantle layer at the posterior part of the basal diencephalon. Between E17.5
and P1, the number of DM-20+ cells increased and progressively invaded the
major white matter tracts. In the hindbrain, DM-20+ cells appeared at E12.5
in the caudal part of the rhombencephalon, and at E14.5 all along the
ventral spinal cord. Between E14.5 and P1, DM-20+ cells progressively
colonized, first ventrally then dorsally, all the spinal cord and more
extensively the white matter tracts. At E14.5, a large gap separated,
rostrally, the medullary columns from the mantle layer cells in the
prosencephalon, suggesting that oligodendrocytes in the mid- and forebrain
originate from a different pool of precursors than in the rhombencephalon
and the spinal cord. Together, these observations suggest that expression
of the DM-20 transcript is an early marker of commitment to the
oligodendrocyte lineage, and that oligodendrocyte precursors originate in a
ventrally restricted region.
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