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Journal of Neuroscience, Vol 15, 970-980, Copyright © 1995 by Society for Neuroscience
Regionalization of the developing forebrain: a comparison of FORSE-1, Dlx-2, and BF-1
S Tole and PH Patterson
Division of Biology, California Institute of Technology, Pasadena 91125.
The FORSE-1 monoclonal antibody (mAb) was generated using a strategy
designed to produce mAbs against neuronal cell surface antigens that might
be regulated by regionally restricted transcription factors in the
developing CNS. To determine whether FORSE-1 has a labeling pattern similar
to that of known transcription factors, the expression of BF-1 and Dlx-2
was examined by in situ hybridization on sections serial to those labeled
with FORSE-1. We find a striking overlap between BF-1 and FORSE-1 in the
telencephalon; both are expressed in the lateral but not the medial walls
of the telencephalon, and the boundaries of expression are apparently
identical. FORSE-1 staining is detected prior to BF-1 expression in the
neural tube, however. FORSE-1 and Dlx-2 have very different patterns of
expression in the forebrain, suggesting that regulation by Dlx-2 cannot by
itself explain the distribution of FORSE- 1. However, they share some sharp
boundaries in the diencephalon. In addition, FORSE-1 identifies some
previously unknown boundaries in the developing forebrain. These results
indicate that a new cell surface marker can be used to subdivide the
embryonic telencephalon and diencephalon into regions smaller than
previously described, providing necessary complexity to the developmental
patterning in the forebrain.
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