 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 15, 1704-1713, Copyright © 1995 by Society for Neuroscience
Excitatory synaptic transmission in neostriatal neurons: regulation by cyclic AMP-dependent mechanisms
CS Colwell and MS Levine
Mental Retardation Research Center, University of California, Los Angeles 90024-1759.
The purpose of the present study was to examine whether cAMP-dependent
mechanisms regulated excitatory synaptic transmission in the neostriatum. A
brain slice preparation was utilized for intracellular recordings of the
excitatory postsynaptic potentials (EPSPs) evoked by electrical
stimulation. Bath application of forskolin, an activator of adenylate
cyclase, enhanced the EPSP amplitude and duration. This potentiation was
dose dependent and did not occur with the inactive analog
1,9-dideoxyforskolin. Forskolin potentiation was unaltered by treatment
with the GABAA receptor antagonist bicuculline. Furthermore, two inhibitors
of cAMP-dependent protein kinase (PKA), Rp-cAMPS and IP20-amide, attenuated
forskolin's enhancement of the EPSP. In addition, the PKA activator
Sp-cAMPS enhanced excitatory synaptic transmission. Interestingly,
treatment with PKA inhibitors alone depressed while the phosphatase
inhibitor okadaic acid enhanced the synaptic response. These results
suggest a role for tonic kinase and phosphatase activity in regulating
excitatory synaptic transmission in the neostriatum. Finally, forskolin was
found to enhance the responses of neostriatal neurons to glutamate receptor
agonists. This potentiation, which occurred in the presence of
tetrodotoxin, provides at leas part of the explanation for the
cAMP/PKA-dependent regulation of the EPSP. Overall, these results suggest a
role for the adenylate cyclase cascade in the regulation of excitatory
synaptic transmission in the neostriatum.
This article has been cited by other articles:
|
|
|
|
 
S. Mingote, L. Font, A. M. Farrar, R. Vontell, L. T. Worden, C. M. Stopper, R. G. Port, K. S. Sink, J. G. Bunce, J. J. Chrobak, et al.
Nucleus Accumbens Adenosine A2A Receptors Regulate Exertion of Effort by Acting on the Ventral Striatopallidal Pathway
J. Neurosci.,
September 3, 2008;
28(36):
9037 - 9046.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Mueller, J. T. Porter, and G. J. Quirk
Noradrenergic Signaling in Infralimbic Cortex Increases Cell Excitability and Strengthens Memory for Fear Extinction
J. Neurosci.,
January 9, 2008;
28(2):
369 - 375.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-H. Chen, B. K. Harvey, A. F. Hoffman, Y. Wang, Y.-H. Chiang, and C. R. Lupica
MPTP-induced deficits in striatal synaptic plasticity are prevented by glial cell line-derived neurotrophic factor expressed via an adeno-associated viral vector
FASEB J,
January 1, 2008;
22(1):
261 - 275.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Moriguchi, N. Shioda, H. Maejima, X. Zhao, W. Marszalec, J. Z. Yeh, K. Fukunaga, and T. Narahashi
Nefiracetam Potentiates N-Methyl-D-aspartate (NMDA) Receptor Function via Protein Kinase C Activation and Reduces Magnesium Block of NMDA Receptor
Mol. Pharmacol.,
February 1, 2007;
71(2):
580 - 587.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Cepeda and M. S. Levine
Where Do You Think You Are Going? The NMDA-D1 Receptor Trap
Sci. Signal.,
May 2, 2006;
2006(333):
pe20 - pe20.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-C. Huang and K.-S. Hsu
Presynaptic Mechanism Underlying cAMP-Induced Synaptic Potentiation in Medial Prefrontal Cortex Pyramidal Neurons
Mol. Pharmacol.,
March 1, 2006;
69(3):
846 - 856.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Chergui, P. Svenningsson, and P. Greengard
Physiological Role for Casein Kinase 1 in Glutamatergic Synaptic Transmission
J. Neurosci.,
July 13, 2005;
25(28):
6601 - 6609.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Pei, F. J. S. Lee, A. Moszczynska, B. Vukusic, and F. Liu
Regulation of Dopamine D1 Receptor Function by Physical Interaction with the NMDA Receptors
J. Neurosci.,
February 4, 2004;
24(5):
1149 - 1158.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.N. Schiffmann, D. Dassesse, P. d'Alcantara, C. Ledent, S. Swillens, and M. Zoli
A2A receptor and striatal cellular functions: Regulation of gene expression, currents, and synaptic transmission
Neurology,
December 9, 2003;
61(90116):
S24 - 29.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
L. Ding, D. J. Perkel, and M. A. Farries
Presynaptic Depression of Glutamatergic Synaptic Transmission by D1-Like Dopamine Receptor Activation in the Avian Basal Ganglia
J. Neurosci.,
July 9, 2003;
23(14):
6086 - 6095.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Fiorentini, F. Gardoni, P. Spano, M. Di Luca, and C. Missale
Regulation of Dopamine D1 Receptor Trafficking and Desensitization by Oligomerization with Glutamate N-Methyl-D-aspartate Receptors
J. Biol. Chem.,
May 23, 2003;
278(22):
20196 - 20202.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Bocchiaro, S. A. Saywell, and J. L. Feldman
Dynamic Modulation of Inspiratory Drive Currents by Protein Kinase A and Protein Phosphatases in Functionally Active Motoneurons
J. Neurosci.,
February 15, 2003;
23(4):
1099 - 1103.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Flores-Hernandez, C. Cepeda, E. Hernandez-Echeagaray, C. R. Calvert, E. S. Jokel, A. A. Fienberg, P. Greengard, and M. S. Levine
Dopamine Enhancement of NMDA Currents in Dissociated Medium-Sized Striatal Neurons: Role of D1 Receptors and DARPP-32
J Neurophysiol,
December 1, 2002;
88(6):
3010 - 3020.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-C. Huang, Y.-L. Chen, S.-W. Lo, and K.-S. Hsu
Activation of cAMP-Dependent Protein Kinase Suppresses the Presynaptic Cannabinoid Inhibition of Glutamatergic Transmission at Corticostriatal Synapses
Mol. Pharmacol.,
March 1, 2002;
61(3):
578 - 585.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z.-X. Xi, D. A. Baker, H. Shen, D. S. Carson, and P. W. Kalivas
Group II Metabotropic Glutamate Receptors Modulate Extracellular Glutamate in the Nucleus Accumbens
J. Pharmacol. Exp. Ther.,
January 1, 2002;
300(1):
162 - 171.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Catsicas and P. Mobbs
GABAB Receptors Regulate Chick Retinal Calcium Waves
J. Neurosci.,
February 1, 2001;
21(3):
897 - 910.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.N.D. Kerr and J. R. Wickens
Dopamine D-1/D-5 Receptor Activation Is Required for Long-Term Potentiation in the Rat Neostriatum In Vitro
J Neurophysiol,
January 1, 2001;
85(1):
117 - 124.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. K. Seamans, D. Durstewitz, B. R. Christie, C. F. Stevens, and T. J. Sejnowski
Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons
PNAS,
December 22, 2000;
(2000)
11518798.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. V. Bhave, L. Ghoda, and P. L. Hoffman
Brain-Derived Neurotrophic Factor Mediates the Anti-Apoptotic Effect of NMDA in Cerebellar Granule Neurons: Signal Transduction Cascades and Site of Ethanol Action
J. Neurosci.,
May 1, 1999;
19(9):
3277 - 3286.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. L. Snyder, A. A. Fienberg, R. L. Huganir, and P. Greengard
A Dopamine/D1 Receptor/Protein Kinase A/Dopamine- and cAMP-Regulated Phosphoprotein (Mr 32 kDa)/Protein Phosphatase-1 Pathway Regulates Dephosphorylation of the NMDA Receptor
J. Neurosci.,
December 15, 1998;
18(24):
10297 - 10303.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. A. Fienberg, N. Hiroi, P. G. Mermelstein, W. Song, G. L. Snyder, A. Nishi, A. Cheramy, J. P. O'Callaghan, D. B. Miller, D. G. Cole, et al.
DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission
Science,
August 7, 1998;
281(5378):
838 - 842.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. J. Berger, A. C. Hart, and J. M. Kaplan
Galpha s-Induced Neurodegeneration in Caenorhabditis elegans
J. Neurosci.,
April 15, 1998;
18(8):
2871 - 2880.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. K. Hensch, J. A. Gordon, E. P. Brandon, G. S. McKnight, R. L. Idzerda, and M. P. Stryker
Comparison of Plasticity In Vivo and In Vitro in the Developing Visual Cortex of Normal and Protein Kinase A RIbeta -Deficient Mice
J. Neurosci.,
March 15, 1998;
18(6):
2108 - 2117.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. W. Self, L. M. Genova, B. T. Hope, W. J. Barnhart, J. J. Spencer, and E. J. Nestler
Involvement of cAMP-Dependent Protein Kinase in the Nucleus Accumbens in Cocaine Self-Administration and Relapse of Cocaine-Seeking Behavior
J. Neurosci.,
March 1, 1998;
18(5):
1848 - 1859.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Cepeda, C. S. Colwell, J. N. Itri, S. H. Chandler, and M. S. Levine
Dopaminergic Modulation of NMDA-Induced Whole Cell Currents in Neostriatal Neurons in Slices: Contribution of Calcium Conductances
J Neurophysiol,
January 1, 1998;
79(1):
82 - 94.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Blank, I. Nijholt, U. Teichert, H. Kugler, H. Behrsing, A. Fienberg, P. Greengard, and J. Spiess
The phosphoprotein DARPP-32 mediates cAMP-dependent potentiation of striatal N-methyl-D-aspartate responses
PNAS,
December 23, 1997;
94(26):
14859 - 14864.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Martin, Z. Nie, and G. R. Siggins
Metabotropic Glutamate Receptors Regulate N-Methyl-D-Aspartate-Mediated Synaptic Transmission in Nucleus Accumbens
J Neurophysiol,
December 1, 1997;
78(6):
3028 - 3038.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Umemiya and L. A. Raymond
Dopaminergic Modulation of Excitatory Postsynaptic Currents in Rat Neostriatal Neurons
J Neurophysiol,
September 1, 1997;
78(3):
1248 - 1255.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-W. Xie and D. V. Lewis
Involvement of cAMP-Dependent Protein Kinase in µ-Opioid Modulation of NMDA-Mediated Synaptic Currents
J Neurophysiol,
August 1, 1997;
78(2):
759 - 766.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Harvey and M. G. Lacey
A Postsynaptic Interaction between Dopamine D1 and NMDA Receptors Promotes Presynaptic Inhibition in the Rat Nucleus Accumbens via Adenosine Release
J. Neurosci.,
July 15, 1997;
17(14):
5271 - 5280.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Hernandez-Lopez, J. Bargas, D. J. Surmeier, A. Reyes, and E. Galarraga
D1 Receptor Activation Enhances Evoked Discharge in Neostriatal Medium Spiny Neurons by Modulating an L-Type Ca2+ Conductance
J. Neurosci.,
May 1, 1997;
17(9):
3334 - 3342.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. M. Lalley, O. Pierrefiche, A. M. Bischoff, and D. W. Richter
cAMP-Dependent Protein Kinase Modulates Expiratory Neurons In Vivo
J Neurophysiol,
March 1, 1997;
77(3):
1119 - 1131.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Martin, Z. Nie, and G. R. Siggins
µ-Opioid Receptors Modulate NMDA Receptor-Mediated Responses in Nucleus Accumbens Neurons
J. Neurosci.,
January 1, 1997;
17(1):
11 - 22.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Herrero and J. Sanchez-Prieto
cAMP-dependent Facilitation of Glutamate Release by beta -Adrenergic Receptors in Cerebrocortical Nerve Terminals
J. Biol. Chem.,
November 29, 1996;
271(48):
30554 - 30560.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Levine, K. L. Altemus, C. Cepeda, H. C. Cromwell, C. Crawford, M. A. Ariano, J. Drago, D. R. Sibley, and H. Westphal
Modulatory Actions of Dopamine on NMDA Receptor-Mediated Responses Are Reduced in D1A-Deficient Mutant Mice
J. Neurosci.,
September 15, 1996;
16(18):
5870 - 5882.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. K. Seamans, D. Durstewitz, B. R. Christie, C. F. Stevens, and T. J. Sejnowski
Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons
PNAS,
January 2, 2001;
98(1):
301 - 306.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
