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Journal of Neuroscience, Vol 15, 1819-1834, Copyright © 1995 by Society for Neuroscience
Age-dependent specification of the corticocortical connections of cerebral grafts
MF Barbe and P Levitt
Department of Physical Therapy, Temple University, Philadelphia, Pennsylvania 19140.
To investigate further the factors involved in the development of cerebral
cortical circuitry, we examined the organization of corticocortical
connections of heterotopic grafts of fetal cortex placed into neonatal rat
cortices. Presumptive perirhinal or sensorimotor areas of the cerebral wall
were removed as slabs from embryonic day 12 (E12), E13, or E14 rats and
transplanted heterotopically into either rostral perirhinal or sensorimotor
cortical areas of neonatal rats. Two weeks later, the afferent cortical
connections of the grafts were labeled by placing DilC18(-3) (Dil) into
each transplant site. Both the E12 and E13 heterotopic transplants of
presumptive perirhinal cortex contain mostly precursor cells. When these
grafts are placed into sensorimotor cortex, callosal connections are formed
primarily with the contralateral sensorimotor (Sml) area, the normal
projection of Sml cortex. In contrast, the E14 heterotopic transplants of
the perirhinal cortical wall, containing many more postmitotic neurons,
developed contralateral connections with both sensorimotor and rostral
perirhinal cortices. Thus, when precursor cells are transplanted
heterotopically, by using E12/E13 donor tissue, the grafts receive
projections that are similar to those of the host cortical area. When older
cortical neurons, together with precursors, are transplanted into a
heterotopic cortical area, by using E14 donor tissue, their cortical
connections exhibit both host and original donor phenotypes. The data are
consistent with our previous analysis of thalamocortical connections of
grafts (Barbe and Levitt, 1992b) and suggest the existence of a cell-cell
recognition system for thalamocortical and corticocortical circuit
formation, whose mechanisms of action may be linked to the timing of
neurogenesis.
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