 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 15, 2030-2039, Copyright © 1995 by Society for Neuroscience
Spatial memory deficits, increased phosphorylation of the transcription factor CREB, and induction of the AP-1 complex following experimental brain injury
PK Dash, AN Moore and CE Dixon
Department of Neurobiology and Anatomy, University of Texas-Houston Health Science Center 77225.
Traumatic brain injury causes both short- and long-term neurological
impairments. A cascade of biochemical changes triggered by the injury may
increase the expression of several genes, which has been hypothesized to
contribute to the observed cognitive deficits. The mechanism(s) of
induction for these genes is not yet known. We present evidence that
lateral cortical impact injury in rats that produces spatial memory
deficits also increases phosphorylation of the transcription factor CREB
(cAMP response element binding). Subsequent to the phosphorylation of CREB,
c-Fos expression and the AP-1 complex are enhanced. The temporal and
spatial activation of c-Fos is consistent with it being induced by
phosphorylated CREB proteins. Thus, CREB-mediated gene activation may
contribute to the observed behavioral deficits. Further elucidation of the
biochemical and pathophysiological changes will be of importance for
clinical therapy.
This article has been cited by other articles:
|
|
|
|
 
J. Zhao, A. N. Moore, J. B. Redell, and P. K. Dash
Enhancing Expression of Nrf2-Driven Genes Protects the Blood Brain Barrier after Brain Injury
J. Neurosci.,
September 19, 2007;
27(38):
10240 - 10248.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. B. Redell, A. N. Moore, and P. K. Dash
Expression of the Prodynorphin Gene after Experimental Brain Injury and Its Role in Behavioral Dysfunction
Experimental Biology and Medicine,
March 1, 2003;
228(3):
261 - 269.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Tischkau, J. W. Mitchell, S.-H. Tyan, G. F. Buchanan, and M. U. Gillette
Ca2+/cAMP Response Element-binding Protein (CREB)-dependent Activation of Per1 Is Required for Light-induced Signaling in the Suprachiasmatic Nucleus Circadian Clock
J. Biol. Chem.,
January 3, 2003;
278(2):
718 - 723.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. O'Dell, R. Raghupathi, P. B. Crino, J. H. Eberwine, and T. K. McIntosh
Traumatic Brain Injury Alters the Molecular Fingerprint of TUNEL-Positive Cortical Neurons In Vivo: A Single-Cell Analysis
J. Neurosci.,
July 1, 2000;
20(13):
4821 - 4828.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Rosenfeldt, D. J. Lee, and F. Grinnell
Increased c-fos mRNA Expression By Human Fibroblasts Contracting Stressed Collagen Matrices
Mol. Cell. Biol.,
May 1, 1998;
18(5):
2659 - 2667.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. K. Mcintosh, K. E. Saatman, and R. Raghupathi
REVIEW {blacksquare} : Calcium and the Pathogenesis of Traumatic CNS Injury: Cellular and Molecular Mechanisms
Neuroscientist,
May 1, 1997;
3(3):
169 - 175.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R.-R. Ji and F. Rupp
Phosphorylation of Transcription Factor CREB in Rat Spinal Cord after Formalin-Induced Hyperalgesia: Relationship to c-fos Induction
J. Neurosci.,
March 1, 1997;
17(5):
1776 - 1785.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kataoka, R. Alam, P. K. Dash, and F. M. Yatsu
Inhibition of PDGF-Mediated Proliferation of Vascular Smooth Muscle Cells by Calcium Antagonists
Stroke,
February 1, 1997;
28(2):
364 - 369.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. M. Ding, L. E. Faiman, W. J. Hurst, L. R. Kuriashkina, and M. U. Gillette
Resetting the Biological Clock: Mediation of Nocturnal CREB Phosphorylation via Light, Glutamate, and Nitric Oxide
J. Neurosci.,
January 15, 1997;
17(2):
667 - 675.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. N. Moore, M. N. Waxham, and P. K. Dash
Neuronal Activity Increases the Phosphorylation of the Transcription Factor cAMP Response Element-binding Protein (CREB) in Rat Hippocampus and Cortex
J. Biol. Chem.,
June 14, 1996;
271(24):
14214 - 14220.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
